A5101466528- Neuroscience and Neural Engineering
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Neuroscience and Music Perception
- Nuclear Engineering Thermal-Hydraulics
- RNA and protein synthesis mechanisms
- Marine animal studies overview
- Non-Destructive Testing Techniques
- Neural dynamics and brain function
- Muscle activation and electromyography studies
- Water Systems and Optimization
- Neurobiology and Insect Physiology Research
- Vagus Nerve Stimulation Research
Boston University
2017-2020
Academy of Military Transportation
2019
Objective. Most preparations for making neural recordings degrade over time and eventually fail due to insertion trauma reactive tissue response. The magnitudes of these responses are thought be related the electrode size (specifically, cross-sectional area), relative stiffness electrode, degree tolerance material. Flexible carbon fiber ultra-microelectrodes have a much smaller cross-section than traditional electrodes low reactivity, thus may enable improved longevity in central peripheral...
Objective. The vision of bioelectronic medicine is to treat disease by modulating the signaling visceral nerves near various end organs. In small animal models, interest can have diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. this study, we present a novel interface demonstrate its use stimulation recording in nerves. Approach. We design fabricate micro-scale electrode-laden nanoclips capable interfacing with as 50 µm diameter....
Applying an accurate parametric prediction model to identify abnormal or false pressurizer water levels (PWLs) is critical the safe operation of marine pressurized reactors (PWRs). Recently, deep-learning-based models have proved be a powerful feature extractor perform high-accuracy prediction. However, effectiveness still suffers from two issues in PWL prediction: correlations shifting over time between and other parameters, example imbalance fluctuation examples (minority) stable...
Optical techniques for recording and manipulating neural activity have traditionally been constrained to superficial brain regions due light scattering. New are needed extend optical access large 3D volumes in deep areas, while retaining local connectivity.We developed a method implant bundles of hundreds or thousands microfibers, each with diameter 8 μm. During insertion, fiber moves independently, following path least resistance. The fibers achieve near total internal reflection, enabling...
Abstract Coordinated skills such as speech or dance involve sequences of actions that follow syntactic rules in which transitions between elements depend on past actions. Canary songs are comprised repeated syllables, called phrases, and the ordering these phrases follows long-range rules, where choice what to sing depends song structure many seconds prior. The neural substrates support correlations unknown. Using miniature head-mounted microscopes cell-type-specific genetic tools, we...
Abstract Most preparations for making neural recordings degrade over time and eventually fail due to insertion trauma reactive tissue response. The magnitudes of these responses are thought be related the electrode size (specifically, cross-sectional area) relative stiffness material. Carbon fiber ultramicroelectrodes have a much smaller cross-section than traditional electrodes thus may enable improved longevity in central peripheral nervous systems. Only two carbon array designs been...
ABSTRACT Sparse sequences of neuronal activity are fundamental features neural circuit computation; however, the underlying homeostatic mechanisms remain poorly understood. To approach these questions, we have developed a method for cellular-resolution imaging in organotypic cultures adult zebra finch brain, including portions intact song circuit. These vitro networks can survive weeks, and display mature neuron morphologies. Neurons within slices exhibit diversity spontaneous...