A5047935492- Optical Imaging and Spectroscopy Techniques
- Additive Manufacturing and 3D Printing Technologies
- Photoreceptor and optogenetics research
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- 3D Printing in Biomedical Research
- Advanced Fluorescence Microscopy Techniques
- Carbon dioxide utilization in catalysis
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Atomic and Subatomic Physics Research
- Electrospun Nanofibers in Biomedical Applications
- Medical Imaging Techniques and Applications
- Injection Molding Process and Properties
Boston University
2021-2024
Athlone Institute of Technology
2019
The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication dosage forms, paving way personalized medicine. In this study, oral forms two drug concentrations, namely 2.50% and 5.00%, were fabricated via stereolithography (SLA) using a novel photopolymerizable resin formulation based on monomer mixture that, to date, not been reported in literature, with paracetamol aspirin selected as model drugs. order produce ratio poly(ethylene glycol)...
Neurophotonics was launched in 2014 coinciding with the launch of BRAIN Initiative focused on development technologies for advancement neuroscience. For last seven years, Neurophotonics' agenda has been well aligned this focus neurotechnologies featuring new optical methods and tools applicable to brain studies. While 2.0 is pivoting towards applications these novel quest understand brain, article we review an extensive diverse toolkit explore function that have emerged from related...
Widefield microscopy of the entire dorsal part mouse cerebral cortex enables large-scale ("mesoscopic") imaging different aspects neuronal activity with spectrally compatible fluorescent indicators as well hemodynamics via oxy- and deoxyhemoglobin absorption. Versatile cost-effective systems are needed for large-scale, color-multiplexed multiple intrinsic contrasts.
Poly-l-lactic acid (PLLA) is one of the most common bioabsorbable materials in medical device field. However, its use load-bearing applications limited due to inferior mechanical properties when compared many competing metal-based permanent and materials. The objective this study was directly compare influence both annealing biaxial expansion processes improve material PLLA. Results showed that led an overall increase crystallinity crystallites formed during were α’ α forms. 2D-WAXS patterns...
Additive manufacturing has been of great interest research in various applications due to their ease processability, cost effectiveness and adaptability. In this study Poly Lactic Acid (PLA) was used as the base polymer which reinforced with Halloysite Nanotubes (HNT) powder they are known be biodegradable high mechanical properties individually. HNT loadings 3% 5% were added PLA by method twin screw extrusion pelletized. For comparison, on its own also extruded The resultant homogeneous...
Biodegradable polymers play a crucial role in the medical device field, with broad range of applications such as suturing, drug delivery, tissue engineering, scaffolding, orthopaedics, and fixation devices. Poly-l-lactic acid (PLLA) is one most commonly used investigated biodegradable polymers. The objective this study was to determine influence low shear microbore extrusion exerts on properties high molecular weight PLLA for tubing applications. Results showed that even at rates there...
Abstract Cholinergic signaling is involved with a variety of brain functions including learning and memory, attention, behavioral state modulation. The spatiotemporal characteristics neocortical acetylcholine (ACh) release in response to sensory inputs are poorly understood, but lack intra-region topographic organization cholinergic projections from the basal forebrain has suggested diffuse patterns volume transmission. Here, we use mesoscopic imaging fluorescent ACh sensors show that visual...
Ascending neuromodulatory projections from deep brain nuclei generate internal states that differentially engage specific neuronal cell types. Because neurovascular coupling is cell-type and transmitters have vasoactive properties, we hypothesized the impulse response function (IRF) linking spontaneous activity with hemodynamics would depend on neuromodulation. To test this hypothesis, used optical imaging to measure (1) release of norepinephrine (NE) or acetylcholine (ACh), (2) Ca 2+ local...
Significance: Widefield microscopy of the entire dorsal part mouse cerebral cortex enables large-scale (mesoscopic) imaging neuronal activity with fluorescent indicators as well hemodynamics via oxy- and deoxyhemoglobin absorption. Versatile cost-effective systems are needed for large-scale, color-multiplexed multiple intrinsic contrasts. Aim: Develop a system mesoscopic two reflectance channels. Approach: Excitation red green fluorescence is achieved through epi-illumination. Hemoglobin...
We demonstrate the feasibility of fMRI in mice with large-scale chronic optical cranial windows.