A5040150221- Graphene and Nanomaterials Applications
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- MXene and MAX Phase Materials
- 3D Printing in Biomedical Research
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Nanomaterials in Catalysis
- SARS-CoV-2 and COVID-19 Research
- Nanoparticles: synthesis and applications
- Carbon and Quantum Dots Applications
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Pancreatic function and diabetes
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- Osteoarthritis Treatment and Mechanisms
- Cancer Research and Treatments
- Biomedical Ethics and Regulation
Ankara University
2016-2025
Stem Cell Institute
2019-2025
University of Manchester
2014-2018
University College London
2012-2017
University of London
2010-2011
Nottingham City Hospital
2008
University of Nottingham
2008
Abstract The appeal of carbon dots (CDs) has grown recently, due to their established biocompatibility, adjustable photoluminescence properties, and excellent water solubility. For the first time in literature, copper chlorophyllin‐based (Chl‐D CDs) are successfully synthesized. Chl‐D CDs exhibit unique spectroscopic traits found induce a Fenton‐like reaction, augmenting photodynamic therapy (PDT) efficacies via ferroptotic apoptotic pathways. To bolster therapeutic impact CDs, widely used...
Abstract Introduction IL-17 plays an important role in autoimmunity, promoting inflammation and invasion multiple sclerosis, rheumatoid arthritis type I diabetes. The of cancer is unclear, however, as there are few studies examining protein expression cancer. We therefore examined human breast modelled its potential biological significance vitro . Methods Immunohistochemistry was used to determine cancers. Matrigel assays were employed examine the effect on cell by a panel lines. matrix...
Nanotechnology can offer a number of options against coronavirus disease 2019 (COVID-19) acting both extracellularly and intracellularly to the host cells. Here, aim is explore graphene oxide (GO), most studied 2D nanomaterial in biomedical applications, as nanoscale platform for interaction with SARS-CoV-2. Molecular docking analyses GO sheets on three different structures: SARS-CoV-2 viral spike (open state - 6VYB or closed 6VXX), ACE2 (1R42), ACE2-bound complex (6M0J) are performed. shows...
This study describes the previously unreported intrinsic capacity of poly-L-lysine (PLL) sixth generation (G 6 ) dendrimer molecules to exhibit systemic antiangiogenic activity that could lead solid tumor growth arrest. The PLL-dendrimer-inhibited tubule formation SVEC4-10 murine endothelial cells and neovascularization in chick embryo chorioallantoic membrane (CAM) assay. Intravenous administration PLL-dendrimer into C57BL/6 mice inhibited vascularisation Matrigel plugs implanted...
Abstract Thanks to its photocatalytic property, graphitic carbon nitride (g‐C 3 N 4 ) is a promising candidate in various applications including nanomedicine. However, studies focusing on the suitability of g‐C for cancer therapy are very limited and possible underlying molecular mechanisms unknown. Here, it demonstrated that photoexcitation can be used effectively photodynamic therapy, without using any other carrier or additional photosensitizer. Upon light exposure, treatment kills cells,...
Ribavirin is a guanosine analog with broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 of this drug molecule via in vitro, silico, and molecular techniques. showed Vero E6 cells following SARS-CoV-2 infection, whereas itself did not any toxic effect over concentration range tested. In silico analysis suggested that ribavirin has impact SARS-CoV-2, acting at different viral proteins. According detailed techniques, was shown decrease...
Almost all currently used vaccines against COVID-19 consist of either non-viral or viral nanoparticles. Here we attempt to understand the reasons behind success such advanced nanoscale vaccine technologies compared with clinically established conventional vaccines, and lessons be learnt from this potentially transformative development in adoption acceptance nanotechnology for medicine.
Although vanadium-based metallodrugs are recently explored for their effective anti-inflammatory activity, they frequently cause undesired side effects. Among 2D nanomaterials, transition metal carbides (MXenes) have received substantial attention promise as biomedical platforms. It is hypothesized that vanadium immune properties can be extended to MXene compounds. Therefore, carbide (V4 C3 ) synthetized, evaluating its biocompatibility and intrinsic immunomodulatory By combining multiple...
One of the major obstacles to clinical development gene silencing by small interfering RNA (siRNA) is its effective cytoplasmic delivery. Carbon nanotubes have been proposed as novel nanomaterials that can offer significant advantages for intracellular delivery nucleic acids, such siRNA. We recently demonstrated in a proof-of-principle study amino-functionalized multiwalled carbon (f-MWNT) effectively deliver vivo an siRNA sequence, triggering cell apoptosis results human lung xenograft...
Thanks to its intrinsic properties, two-dimensional (2D) bismuth (bismuthene) can serve as a multimodal nanotherapeutic agent for lung cancer acting through multiple mechanisms, including photothermal therapy (PTT), magnetic field-induced hyperthermia (MH), immunogenic cell death (ICD), and ferroptosis. To investigate this possibility, we synthesized bismuthene from the exfoliation of 3D layered bismuth, prepared facile method that developed involving surfactant-assisted chemical reduction,...
Abstract The increasing exposure to nanoplastics (NPs) raises significant concerns for human health, primarily due their potential bioaccumulative properties. While NPs have recently been detected in blood, interactions with specific immune cell subtypes and impact on regulation remain unclear. In this proof‐of‐concept study, model palladium‐doped polystyrene (PS‐Pd NPs) are utilized enable single‐cell mass cytometry (CyTOF) detection. size‐dependent of carboxylate (50–200 nm) is...
Abstract Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and dots, have attracted a great deal scientific attention due to their potential biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could modulated the different physicochemical properties of (e.g. structure, size, chemical functions), either stimulating or suppressing response. However, harmonized cutting-edge...
Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a rapidly spreading pandemic and is severely threatening public health globally. The human-to-human transmission route of SARS-CoV-2 now well established. reported clinical observations symptoms this infection in humans appear range between being asymptomatic pneumonia. virus can be transmitted through aerosols droplets that are released into air carrier, especially when person...
The ability to induce the reprogramming of somatic mammalian cells a pluripotent state by forced expression specific transcription factors has helped redefine rules cell fate and plasticity, as well open possibilities for disease modeling, drug screening regenerative medicine. Here, we hypothesized that non-viral four originally discovered defined (OKSM) in adult mice could result vivo transfected tissue situ. We show single hydrodynamic tail-vein (HTV) injection two plasmids encoding...