A5040864692- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Adipose Tissue and Metabolism
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
- Antimicrobial Resistance in Staphylococcus
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Heart Failure Treatment and Management
- Streptococcal Infections and Treatments
- Advanced MRI Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Infectious Aortic and Vascular Conditions
- Anesthesia and Neurotoxicity Research
KU Leuven
2012-2021
Universitair Ziekenhuis Leuven
2001-2021
Vicore Pharma (Sweden)
2018
Creative Commons
2018
Universitat de València
2015
Biomedical Research Networking Center on Neurodegenerative Diseases
2015
UCLouvain
2013
Medizinische Hochschule Hannover
2013
MultiMedica
2013
University of Salerno
2013
Abstract Cardiovascular disease associated with metabolic syndrome has a high prevalence, but the mechanistic basis of cardiomyopathy remains poorly understood. We characterised cardiac transcriptome in murine (MetS) model (LDLR−/−; ob/ob, DKO) relative to healthy, control heart (C57BL/6, WT) and transcriptional changes induced by ACE-inhibition those hearts. RNA-Seq, differential gene expression transcription factor analysis identified 288 genes differentially expressed between DKO WT...
The aim here is to analyse epidemiology, optimal treatment, and predictors of 6-month mortality in infective endocarditis (IE).A prospective observational cohort study included 193 patients with 203 episodes definite IE by the modified Duke criteria. Thirty-four percent involved prosthetic valves. Thirty-three were nosocomial. Forty-three staphylococci, 26% streptococci, 17% enterococci. At least one complication occurred 79% 63% had surgical intervention. Six-month was 22%: 33% for 24%...
Prosthesis-patient mismatch (P-PtM) after aortic valve replacement results in disturbed performance associated with increased pressure gradients. However, it is unknown whether this can be related to future structural deterioration (SVD) of the bioprosthesis.In 564 patients (mean age, 74+/-5 years) receiving an bioprosthesis, clinical follow-up (median, 6.1 years; maximum, 16.4 was analyzed including echocardiography. SVD diagnosed 40 (7%) as substantially stenosis (n=24) or regurgitation...
Background— Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved left ventricular (LV) remodeling. Whether expression is related to interstitial fibrosis or LV dysfunction patients with chronic pressure overload–induced hypertrophy, however, unknown. Methods Results— Therefore, cardiac biopsies were taken 36 isolated aortic stenosis (AS) 29 control without hypertrophy. Microarray analysis revealed significantly increased...
Durability assessment of mitral valve repair for degenerative incompetence is actually limited to reoperation as the primary indicator, with valve-related risk factors late death a secondary indicator. We assessed serial echocardiographic follow-up function an indicator durability repair.In 242 patients who had undergone incompetence, function, rate reoperation, survival, and clinical outcome was studied. At 8 years after repair, excellent, survival 90.9+/-3.2%, freedom from 94.2+/-2.3%,...
Tight blood glucose control with insulin reduces morbidity and mortality of critically ill patients. However, the relative impact maintaining normoglycemia glycemia-independent actions remains unknown. We therefore independently manipulated plasma levels in burn-injured, parentally fed rabbits over 7 days to obtain four study groups: two normoglycemic groups either normal or elevated hyperglycemic levels. studied glycemia effects on survival; myocardial contractility an open chest...
We report clinical outcomes following transcatheter aortic valve implantation (TAVI), using the CoreValve revalving system (18 Fr transfemoral or subclavian) Edwards Sapien (22 24 transapical) as part of a Belgian prospective non-randomized multicentre registry. All 15 centres performing TAVI participated to this registry (seven exclusively Sapien, eight CoreValve). consecutive high-risk symptomatic patients with severe stenosis were evaluated by heart team and screened for eligibility TAVI....
Background— The impact of interleukin (IL)-6 on skeletal muscle function remains the subject controversy. Methods and Results— effects 7-day subcutaneous administration recombinant human IL-6 were examined at 3 doses, 50, 100, or 250 μg · kg −1 d , in rats. Skeletal mass decreased dose-dependently (with increasing dose: diaphragm, −10%, P =NS; −15%, =0.0561; −15% <0.05; gastrocnemius, −9%, −18%, <0.005) because decreases cross-sectional area all fiber types without alterations...
Influx of Ca 2+ ions through α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors contributes to neuronal damage in stroke, epilepsy, and neurodegenerative disorders such as ALS. The permeability AMPA is largely determined by the glutamate receptor 2 (GluR2) subunit, lacking GluR2 being permeable ions. We identified a difference expression motor neurons from two rat strains, resulting vulnerability receptor-mediated excitotoxicity both vitro vivo . Astrocytes ventral spinal...
Atrial fibrillation (AF) is associated with extracellular matrix remodeling involving atrial fibrosis and dilatation. Angiotensin II mediated pathways metalloproteinases (MMPs) have been implicated in these processes. Our aim was to study structural the expression of angiotensin receptor subtypes MMPs their inhibitors (TIMPs) patients mitral valve disease without AF.Biopsies from right left appendages (RA LA) were taken undergoing CABG (n=9, all sinus rhythm (SR)) or surgery (MVS; n=19; 9...
Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human right ventricular hypertrophy, but its role left (LV) failure remains incompletely understood. We therefore measured LV PDE5 patients with advanced systolic heart and characterized remodeling after myocardial infarction transgenic mice cardiomyocyte-specific overexpression (PDE5-TG).Immunoblot immunohistochemistry techniques revealed that was greater explanted LVs from...
Hypertension is an underlying risk factor for cardiovascular disease. Despite this, its pathogenesis remains unknown in most cases. Recently, the transient receptor potential (TRP) channel family was associated with development of several diseases linked to hypertension. The melastatin TRP channels TRPM4 and TRPM5 have distinct properties within family: they form nonselective cation activated by intracellular calcium ions. Here we report identification proteins endothelial cells, heart,...
Background— β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced diseased human myocardium, but its impact on unknown. Methods Results— Mice with myocyte-specific (β3-TG) wild-type (WT) littermates were used compare myocardial isoproterenol (Iso) or Angiotensin II (Ang II). β3-TG WT had similar morphometric hemodynamic parameters at baseline. colocalized caveolin-3, endothelial nitric oxide...
It is well accepted that strain and rate deformation parameters are not only a measure of intrinsic myocardial contractility but also influenced by changes in cardiac load structure. To date, no information available on the relative importance these confounders. This study was designed to investigate how rate, measured Doppler echocardiography, relate individual factors determine performance. Echocardiographic conductance measurements were simultaneously performed mice which determinants...
Microvascular endothelium in different organs is specialized to fulfill the particular needs of parenchymal cells. However, specific information about heart capillary endothelial cells (ECs) lacking.Using microarray profiling on freshly isolated ECs from heart, brain, and liver, we revealed a genetic signature for microvascular identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This was largely shared with skeletal muscle adipose tissue enriched genes encoding fatty...
Brain death can have an impact on donor organ function. This is often attributed to altered hormonal, mainly thyroidal, status after brain death. A second possible explanation that during the process, blood flow redistributed, causing ischemic damage in underperfused organs or regions. We investigated redistribution with colored microspheres rat early and late death, induced by inflation of intracranial balloon, correlated this global hemodynamic situation plasma catecholamine...
We planned a study to assess the safety, feasibility, and efficacy of Impella micro-axial blood pump in patients with cardiogenic shock.From January 2001 September 2002 inclusive, 16 shock (maximal inotropic support IABP 11 cases) underwent left ventricle unloading pump. 6 were placed via femoral artery (patients coronary care unit) 10 directly through aorta (postcardiotomy heart failure). In three patients, device was used combination ECMO. Mean age 60 years (range 43 - 75), male.A stable...