A5084505733- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Electrospun Nanofibers in Biomedical Applications
- Heart Rate Variability and Autonomic Control
- Pluripotent Stem Cells Research
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Wireless Power Transfer Systems
- Neuropeptides and Animal Physiology
- Ubiquitin and proteasome pathways
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Caveolin-1 and cellular processes
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- S100 Proteins and Annexins
St. Luke's Hospital
2016-2022
First Affiliated Hospital of Dalian Medical University
2020
Dalian Medical University
2020
Texas Medical Center
2019
St. Luke's Episcopal Hospital
2008-2015
The University of Texas Health Science Center at San Antonio
2014-2015
The University of Texas at Austin
2015
The University of Texas Health Science Center at Houston
2012-2014
Indiana University – Purdue University Indianapolis
2010-2013
Ministry of Education
2013
Background— Long-QT syndrome (LQTS) is an inherited disorder associated with sudden cardiac death. The cytoskeletal protein syntrophin-α 1 (SNTA1) known to interact the sodium channel (hNa v 1.5), and we hypothesized that SNTA1 mutations might cause phenotypic LQTS in patients genotypically normal hNa 1.5 by secondarily disturbing function. Methods Results— Mutational analysis of was performed on 39 (QTc≥480 ms) previously negative genetic screening for LQTS-causing genes. We identified a...
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to combinatorial anti–programmed cell death 1 and anti–cytotoxic T lymphocyte antigen–4 antibodies also presented cardiovascular toxicities observed clinically ICI therapy, including myocarditis arrhythmia. Female were preferentially affected compared male mice, consistent a previously described...
Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction (MI). Accumulating data show that ischemia, sympathetic activation, and inflammation contribute to arrhythmogenesis. However, the role mechanisms abnormal mechanical stress in ventricular arrhythmia MI remain undefined. We aimed examine impact increased identify sensor Piezo1 MI. Concomitant with pressure, Piezo1, as newly recognized mechano-sensitive cation channel, was most up-regulated...
Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle associated with sudden cardiac death secondary to ventricular tachyarrhythmias and asystole. However, molecular pathways linking DCM arrhythmias are unknown. We previously identified S196L mutation in exon 4 LBD3-encoded ZASP family death. These findings led us hypothesize that this may precipitate both cytoskeletal conduction abnormalities vivo. Therefore, we investigated role ZASP4 cytoarchitecture ion channel biology.We...
Defects of cytoarchitectural proteins can cause left ventricular noncompaction, which is often associated with conduction system diseases. We have previously identified a p.D117N mutation in the LIM domain-binding protein 3-encoding Z-band alternatively spliced PDZ motif gene (ZASP) patient noncompaction and disturbances. sought to investigate role LBD3 NM_001080114.1 isoform (ZASP1-D117N) for regulation cardiac sodium channel (Na(v)1.5) that plays an important system.Effects ZASP1-wild-type...
Background: Atrial electrical remodeling (AER) is one of the mechanisms by which atrial fibrillation (AF) begets AF. It known that vagal activity increases propensity for However, effects on AER have not been fully investigated. Methods: Adult mongrel dogs were divided in four groups: group I, rapid atria pacing (RAP); II, RAP plus nerve stimulation (VNS); III, and VNS with atropine (0.2 mg/kg/h, intravenous), IV, III vasoactive intestinal polypeptide (VIP) antagonist ([D‐p‐Cl‐Phe 6 , Leu 17...
The heart is a highly complex, multicellular solid organ with energy-demanding processes that require dense vascular network, extensive cell-cell interactions, and extracellular matrix (ECM)-mediated crosstalk among heterogeneous cell populations. Here, we describe the regeneration of left ventricular (LV) wall using decellularized whole rabbit scaffolds recellularized exclusively human induced pluripotent stem cell-derived endothelial cells, cardiomyocytes, other cardiac types. Cells were...
It has been postulated that the loss of arterial compliance may precede cardiovascular diseases, and is an important parameter to consider when evaluating diseases such as essential hypertension (EH) effects antihypertensive treatment. In all, 133 EH patients 147 healthy subjects were enrolled in this study. Large (C1) small (C2) measured by CVProfilor™ DO-2020 CardioVascular Profiling System. Thirty-five randomly received magnesium potassium supplementation (magnesium, 70.8 mg/d; potassium,...
<i>Aims:</i> To investigate whether human adipose-derived mesenchymal stem cell (hAD-MSC) transplantation would ameliorate the healing process of a rabbit model retinal holes. <i>Methods:</i> Retinal holes were made in left eyes 20 New Zealand white rabbits and randomly filled by hAD-MSCs (transplantation group) or phosphate-buffered saline (control group), respectively. Frequency-domain optical coherence tomography (OCT) scan was performed on days 2, 4, 12, 32...
Prostacyclin (PGI2) is a potent vasodilator and important mediator of vascular homeostasis; however, its clinical use limited because short (<2-min) half-life. Thus, we hypothesize that the engineered endothelial progenitor cells (EPCs) constitutively secrete high levels PGI2 may overcome this limitation therapy. A cDNA encoding COX-1-10aa-PGIS, which links human cyclooxygenase-1 (COX-1) to prostacyclin synthase (PGIS), was delivered via nucleofection into outgrowth EPCs derived from rat...
Vasoactive intestinal polypeptide (VIP) is released from intracardiac neurons during vagal stimulation, ischemia, and heart failure, which are associated with increased vulnerability to atrial fibrillation. VIP shortens effective refractory periods in dogs. Endogenous contributes vagally mediated acceleration of electric remodeling. also shown prolong the duration acetylcholine-induced However, ionic mechanisms underlying effects largely unknown.The on transmembrane ion channels were studied...
Background: The potential pathophysiological role of common SCN5A polymorphisms in cardiac arrhythmias has been increasingly recognized. However, little is known about the impact those on pharmocological response hNav1.5 to various antiarrhythmic agents. Methods and Results: polymorphism, S524Y, was studied comparison with wild type (WT) define SCN5A‐Q1077del variant. ion channel gating kinetics pharmacology were evaluated using whole‐cell patch‐clamp methods HEK‐293 cells. Consistent a...