A5087000760- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Bone and Joint Diseases
- Hip disorders and treatments
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Knee injuries and reconstruction techniques
- Circular RNAs in diseases
- Lower Extremity Biomechanics and Pathologies
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Bone fractures and treatments
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Vitamin D Research Studies
- Metabolomics and Mass Spectrometry Studies
- Cardiac electrophysiology and arrhythmias
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Shanxi Agricultural University
2025
Central South University
2005-2024
University of South China
2024
Mianyang Central Hospital
2024
University of Electronic Science and Technology of China
2024
Central South University of Forestry and Technology
2024
United States Bone and Joint Initiative
2023
Xi'an Jiaotong University
2008-2019
Xiangya Hospital Central South University
2005
Abstract Background Osteoporosis is a disease threatening the health of millions individuals. Melatonin found to be potential anti-osteoporosis drug. However, whether melatonin plays role against osteoporosis at different stages menopause and underlying mechanisms are unknown. Methods Ovariectomy was utilized as model perimenopausal postmenopausal osteoporosis. A total 100 mg/kg melatonin, or solvent alone, added drinking water rats over 8 weeks. Perimenopausal immediately received...
Objective: A prospective, multicenter, randomized controlled trial was conducted to explore the short-term effect of a new robotic-assisted total knee arthroplasty (TKA) system, and clinical radiographic effectiveness between system conventional TKA were compared analyzed. Materials Methods: Overall, 144 patients randomly divided into two groups, wherein 72 underwent using robotic‑assisted TKA. The demographic data parameters collected. factors influencing postoperative hip–knee–ankle (HKA)...
Polyetheretherketone (PEEK) has been becoming a popular implant material in orthopaedic applications. The lack of bioactivity affects PEEK’s long-term lifetime, and appropriate surface modification is an effective way to enhance its bioactivity. Sulfonation PEEK can endow with 3 D porous network improve This study aimed at exploring optimal sulfonation time post-treatment method sulfonation. was immersed into concentrated sulfuric acid for different times experienced methods turn sulfonated...
Robotic-assisted total knee arthroplasty (RA-TKA) is becoming more and popular as a treatment option for advanced diseases due to its potential reduce operator-induced errors. However, the development of accurate prediction models postoperative outcomes challenging. This study aimed develop nomogram model predict likelihood achieving beneficial functional outcome. The outcome defined improvement Knee Society Score (fKSS) than 10 points, 3 months after RA-TKA by early collection analysis...
Objective Osteonecrosis of the femoral head (ONFH) is a common orthopedic condition that will prompt joint dysfunction, significantly impacting patients’ quality life. However, specific pathogenic mechanisms underlying this disease remain elusive. The objective study to examine differentially expressed messenger RNAs (DE mRNAs) and key genes linked ONFH, concurrently investigating immune cell infiltration features in ONFH patients through application CIBERSORT algorithm. Methods Microarray...
Background: The association between postoperative outcomes of robotic-assisted total knee arthroplasty (RA-TKA) and nutrition status among elderly adults remained unclear. authors aimed to evaluate these associations provide a reference for the surgical technique selection TKA. Methods: In present study, used data from multicenter, prospective, randomized controlled project, which recruited patients underwent TKA therapy. A 88 (age ≥65 years old) were included in this study. Their...
Coccidiosis in chickens is a parasitic disease caused by Eimeria species, resulting significant economic losses to the poultry industry. Among these tenella considered most virulent pathogen, with its infection strongly associated apoptotic response of host cells. modulates cell apoptosis stage-specific manner, suppressing early phase promote intracellular development and triggering later stages facilitate parasite egress progression. This study established an vitro model using 60...
Abstract Exosomes have shown good potential in ischemic injury disease treatments. However, evidence about their effect and molecular mechanisms osteonecrosis of femoral head (ONFH) treatment is still limited. Here, we revealed the cell biology characters ONFH area bone tissue single scale thus identified a novel approach based on M2 macrophages-derived exosomes (M2-Exos). We further show that M2-Exos are highly effective by modulating phenotypes communication between neutrophil endothelium...
Accumulating evidence indicates that dysregulation of miRNAs could contribute to tumor growth and metastasis chondrosarcoma by infuencing cell proliferation invasion. In the current study, we are interested examine role in carcinogenesis progression chondrosarcoma. Here, using comparative miRNA profiling tissues cells cartilage, identified miR-494 as a commonly downregulated patients with cancer line, upregulation inhibit invasion vivo vitro. Moreover, our data demonstrated SOX9, essential...
This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for prevention corticosteroid (CS)-induced osteonecrosis femoral head (ONFH). Patients both genders, aged between 18 65 years, diseases such as systemic lupus erythematosus, nephrosis, dermatosis rheumatoid arthritis indicated CS treatment who did not show magnetic resonance imaging ONFH at...
Lymph node (LN) metastasis at an early stage of cervical cancer is often indicator poor prognosis and critical for subsequent adjuvant therapy. The current study aimed to identify aberrant gene signatures biomarkers patients with cancer. RNA-sequencing data 132 LN negative (N0) 60 positive (N1) samples obtained from Cancer Genome Atlas database were analyzed. Differentially expressed genes identified using R packages 'edgeR' 'limma'. Kyoto Encyclopedia Genes Genomes pathway enrichment Gene...
Abstract Background Osteoarthritis (OA) is a disease of the entire joint involving synovial fibrosis and inflammation. Pathological changes to synovium can accelerate progression OA. Pirfenidone (PFD) potent anti-fibrotic drug with additional anti-inflammatory properties. However, influence PFD on OA unknown. Methods Proliferation human fibroblast-like synoviocytes (FLSs) after treatment TGF-β1 or was evaluated using Cell Counting Kit-8 assay their migration Transwell assay. The expression...
Cervical cancer is the leading cause of death with gynecological malignancies. We aimed to explore molecular mechanism carcinogenesis and biomarkers for cervical by integrated bioinformatic analysis. employed RNA-sequencing details 254 squamous cell carcinomas 3 normal samples from The Cancer Genome Atlas. To distinct pathways, messenger RNA expression was submitted a Gene Set Enrichment Analysis. Kyoto Encyclopedia Genes Genomes protein–protein interaction network analysis differentially...
Abstract By differentiating into and the balance being regulated between M1 (pro‐inflammatory) M2 (anti‐inflammatory) heterogeneous populations, macrophages play critical roles during host immune response in various physiological contexts both health diseases. Besides regulating innate adaptive capacity, are also decisively involved tissue homeostasis. However, how resident after damages is still far from elucidation. In present study, we found that adipose‐derived stem cells (ADSCs)...
Abstract Traumatic osteonecrosis of femoral head (TONFH) is a common orthopedic disease caused by physical injury in hip. However, the unclear pathogenesis mechanism TONFH and lacking simple noninvasive early diagnosis method cause necessity hip replacement for most patients with TONFH. In this study, we aimed to identify circulating microRNAs (miRNAs) integrated bioinformatics analyses as potential biomarker mRNA expression profiles were downloaded from Gene Expression Omnibus database....
Core decompression (CD) with the elimination of osteonecrotic bone is most common strategy for treating early-stage nontraumatic osteonecrosis femoral head (ONFH). Adjuvant treatments are widely used in combination CD as suitable methods therapy. Existing augmentations have to be fabricated advance. Here, we report a novel injectable glycerin-modified polycaprolactone (GPCL) that can adapt shape cavity. GPCL shows great flowability at 52.6 °C. After solidification, its compressive modulus...
The purpose of the present study was to determine learning curve for a novel seven-axis robot-assisted total hip arthroplasty (RA-THA) system, and explore whether it able provide greater accuracy in acetabular cup positioning, superior leg length discrepancy (LLD), offset than conventional methods.A 160 patients which unilateral THA performed second affiliated Hospital Xi'an Jiaotong University from July 2021 September 2022 were studied. first 80 underwent THA, while on subsequent by same...
Adipose derived stem cells (ASCs) with multilineage differentiation capacities have been demonstrated as an alternative cell candidate for in vitro and vivo bone regeneration. This suggests that they may be a potential to repair the defects. We attempted demonstrate use of new biomimetic constructions undifferentiated rabbit adipose-derived (rASCs) fully interconnected porous beta-tricalcium phosphate (β-TCP) scaffolds encapsulated by collagen I hydrogel regeneration critical-sized defect...
Abstract Background Bone defects are often combined with the risk of infection in clinic, and artificial bone substitutes implanted to repair defective bone. However, implant materials carriers for bacterial growth, biofilm can form on surface, which is difficult eliminate using antibiotics host immune system. Magnesium (Mg) was previously reported possess antibacterial potential. Methods In this study, Mg incorporated into poly(lactide- co -glycolic acid) (PLGA) fabricate a PLGA/Mg scaffold...