A5032965826- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Hip disorders and treatments
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Total Knee Arthroplasty Outcomes
Second Affiliated Hospital of Xi'an Jiaotong University
2018-2022
Abstract Traumatic osteonecrosis of femoral head (TONFH) is a common orthopedic disease caused by physical injury in hip. However, the unclear pathogenesis mechanism TONFH and lacking simple noninvasive early diagnosis method cause necessity hip replacement for most patients with TONFH. In this study, we aimed to identify circulating microRNAs (miRNAs) integrated bioinformatics analyses as potential biomarker mRNA expression profiles were downloaded from Gene Expression Omnibus database....
Abstract The purpose of this study was to investigate the possible use resveratrol (Res) reverse abnormal osteogenesis/osteoclastogenesis activity that occurs during femoral head osteonecrosis and explore detailed mechanisms. Application Res bone marrow–derived mesenchymal stem cells in vitro promoted survival, inhibited apoptosis, downregulated expression reactive oxygen species expression. Moreover, application associated with elevated microRNA‐146a (miR‐146a) expression, osteogenic...
Unicompartmental knee osteoarthritis (UKOA) is the early stage of joint degeneration, which characterized by unicompartmental degeneration and mostly occurs in medial compartment. Pain limited motion are main symptoms, affect patients' life quality. Periarticular osteotomy (PKO) for lower extremity alignment correction an effective treatment UKOA with abnormal alignment, could relieve pain improve function adjusting alignment. At present, no clinical guidelines available PKO correction....
Abstract Osteoarthritis (OA) is the most common disease of arthritis, a chronic joint that always correlated with massive destruction such as cartilage destruction, inflammation synovial membrane, and so on. This study aims to explore role long noncoding RNA (lncRNA) LOC101928134 in hyperplasia more specifically, Janus kinase/signal transducers activators transcription (JAK/STAT) signaling pathway an OA rat model. Microarray‐based gene expression analysis was conducted screen out lncRNA...
Objective To evaluate the therapeutic effects of mesenchymal stem cells induced by microencapsulated chondrocytes on repairing intervertebral disc degeneration. Methods Rabbit and bone marrow‐derived (MSC) were derived. Chondrocytes a microcapsule generator to produce (MEC). MSC then co‐cultured with MEC (MSC‐MEC) properties degeneration studied. For in vitro study, cell proliferation, type II collagen, glycosaminoglycan (GAG) The Transwell system (MSC‐MLC) pure used as control group. vivo...