A5088352444- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Bone health and treatments
- Shoulder Injury and Treatment
- Virus-based gene therapy research
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Bone Metabolism and Diseases
- Musculoskeletal synovial abnormalities and treatments
- Bone fractures and treatments
- Spine and Intervertebral Disc Pathology
- Shoulder and Clavicle Injuries
- Viral Infectious Diseases and Gene Expression in Insects
- Ginseng Biological Effects and Applications
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Bone Tissue Engineering Materials
- Sports injuries and prevention
- Venous Thromboembolism Diagnosis and Management
- Lower Extremity Biomechanics and Pathologies
- Optical Imaging and Spectroscopy Techniques
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Xi'an Jiaotong University
2008-2019
Chinese Academy of Agricultural Sciences
2017
Harbin Veterinary Research Institute
2017
National Central University
2008
A hypervirulent fowl adenovirus serotype 4 (FAdV-4) has caused hepatitis-hydropericardium syndrome (HHS) with mortalities that range from 30 to 80% in outbreaks across China since 2015. The FAdV-4 strain was characterized as a novel genotype based on the specific genome characteristics. However, our understanding of dynamic distribution, tissue tropism, and pathogenesis is incomplete. In this study, new, sensitive FAdV-4-specific real-time PCR developed applied detect distribution duck...
Surgery can repair medial meniscal posterior root tears to restore the biological function of meniscus. Transtibial pullout is most common, but suture anchor offers great biomechanical stability and avoids bungee effect. Suture through posteromedial portal has limitations, which have been widely reported. This article describes our technique using a knotless high posterolateral for treatment tears; it achieve an anatomic repair. Through use portal, excellent degree verticality between...
Nuclear factor-kappa B (NF-κB) interactively affects the Wnt/β-catenin pathway and is closely related to different diseases. However, such crosstalk effect in steroid-associated necrosis of femoral head (SANFH) has not been fully explored evaluated. In this study, early-stage SANFH was induced by two doses lipopolysaccharide (LPS, 2 mg/kg/day) three methylprednisolone (MPS, 40 mg/kg/day). LPS pyrrolidine dithiocarbamate (PDTC) were administered activate TLR4/NF-κB selectively block...
Abstract Background Spinal cord injury (SCI) is a disabling disorder, resulting in neurological impairments. This study investigated the mechanism of methyltransferase-like 14 (Mettl14) on apoptosis spinal neurons during SCI repair by mediating pri-microRNA (miR) dependent N6-methyladenosine (m6A) methylation. Methods The m6A content total RNA and Mettl14 levels tissues rats were detected. expression was intervened to examine motor function, neuron apoptosis, recovery neurites. cell model...
Abstract The purpose of this study was to investigate the possible use resveratrol (Res) reverse abnormal osteogenesis/osteoclastogenesis activity that occurs during femoral head osteonecrosis and explore detailed mechanisms. Application Res bone marrow–derived mesenchymal stem cells in vitro promoted survival, inhibited apoptosis, downregulated expression reactive oxygen species expression. Moreover, application associated with elevated microRNA‐146a (miR‐146a) expression, osteogenic...
Osteoporotic fractures and their complications are becoming increasingly harmful to the elderly. This study aimed evaluate clinical results of connected or unconnected bilateral cement after percutaneous kyphoplasty (PKP) in patients with osteoporotic vertebral compression (OVCF). The data 217 single-segment OVCF were retrospectively collected. Patients allocated into 2 groups according bone vertebrae was surgery. surgery-related indexes compared, including operation time; injection volume;...
The aim of the study were to evaluate effect sildenafil against avascular necrosis femoral head (ANFH) in a rabbit model, and role protein kinase G (PKG) pathway vascular endothelial growth factor (VEGF) ANFH.Three weeks after inducing ANFH with methylprednisolone injection, 45 female adult New Zealand white rabbits divided into three groups treated as follows: group SI received daily intraperitoneal dose 10 mg/kg per day; SD identically plus auricular vein injection DT3 (a specific PKG...
Objective. Glucocorticoids can affect the function of bone marrow-derived mesenchymal stem cells (BMMSCs) adversely and merit requirement for a strategy to correct this anomaly; we assessed effect low oxygen (2%) on BMMSCs from rabbits with osteonecrosis. Methods. Bone normal osteonecrosis were divided into four groups: (1) normal-normoxia group, cultured under 20% oxygen; (2) osteonecrosis-normoxia (3) osteonecrosis-low treated 2% (4) normal-low oxygen. The proliferation, osteogenic,...