A5100374158- Bone and Joint Diseases
- Virus-based gene therapy research
- Shoulder Injury and Treatment
- Wnt/β-catenin signaling in development and cancer
- Stress Responses and Cortisol
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Shoulder and Clavicle Injuries
- interferon and immune responses
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Sepsis Diagnosis and Treatment
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Genetic Associations and Epidemiology
- Musculoskeletal synovial abnormalities and treatments
- Ginseng Biological Effects and Applications
- Bone health and treatments
- Diabetic Foot Ulcer Assessment and Management
- Bone health and osteoporosis research
- Orthopedic Surgery and Rehabilitation
- 14-3-3 protein interactions
- Autoimmune and Inflammatory Disorders Research
- Spinal Cord Injury Research
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Central South University
2022
Xiangya Hospital Central South University
2022
The Ohio State University Wexner Medical Center
2021
Institute for Biomedical Engineering
2020
ETH Zurich
2020
Shanghai Jiao Tong University
2015-2019
Shanghai Mental Health Center
2019
Jinhua Central Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Abstract Recent advances in base editing have created an exciting opportunity to precisely correct disease-causing mutations. However, the large size of editors and their inherited off-target activities pose challenges for vivo editing. Moreover, requirement a protospacer adjacent motif (PAM) nearby mutation site further limits targeting feasibility. Here we modify NG-targeting adenine editor (iABE-NGA) overcome these demonstrate high efficiency edit Duchenne muscular dystrophy (DMD) adult...
Abstract Psychological stress has great impacts on the immune system, particularly leukocytes distribution. Although of acute blood distribution are well studied, however, it remains unclear how chronic affects in peripheral circulation. Furthermore, there is no report about role spleen induced by stress. Here we show that contributes to alteration restraint Our data confirmed anxiety-like behavior mice. found decreased CD4/CD8 ratio and elevated percentages natural killer cells, monocytes...
The objective of the current study was to establish a rat model investigate apoptosis in steroid-induced femoral head osteonecrosis occurring via Wnt/β-catenin pathway. Male Sprague–Dawley (SD) rats were randomly divided into control group (group A), B) and sFRP1 C), each consisting 24 rats, intravenously injected with LPS (10 μg/kg body weight). After h, three injections MPS (20 mg/kg weight) administered intramuscularly at 24-h intervals. C 1 protein per day for 30 days, beginning time...
Antipsychotic medication has limited abilities to improve the cognitive impairments that accompany schizophrenia. Adding psychosocial treatment may result in marked improvements function, as compared antipsychotic alone. We hypothesized a combination of individual and family interventions be useful rehabilitation paradigm for schizophrenia.An 18-month follow-up clinical trial 256 stabilized patients with schizophrenia at six communities Shanghai, People's Republic China were randomly...
Background. This study was aimed at investigating the pathogenesis of oxidative stress in steroid-induced avascular necrosis femoral head (SANFH) and exploring mechanism protective effects Panax notoginseng saponins (PNS) on early SANFH. Methods. 80 adult New Zealand rabbits were randomly divided into control group, model PNS group. In equine serum injected auricular vein; then methylprednisolone gluteus. applied for 14 consecutive days before management. At different time points, heads...