Schizophrenia (SCZ) is a severe and debilitating mental disorder, the specific genetic factors that underlie risk for SCZ remain elusive. The autism susceptibility candidate 2 (AUTS2) gene has been reported to be associated with autism, suicide, alcohol consumption, heroin dependence. We hypothesized AUTS2 might SCZ. In present study, three polymorphisms (rs6943555, rs7459368, rs9886351) in were genotyped 410 patients 435 controls using polymerase chain reaction-restriction fragment length...

Interleukin (IL)-8, an important chemokine that regulates the inflammatory response, plays role in periodontitis. Previous studies indicate certain IL-8 gene polymorphisms are associated with periodontitis susceptibility some populations. However, literature is somewhat contradictory, and not all have been examined, particularly Han Chinese individuals. The aim of this study was to investigate association every SNP chronic We analyzed 23 SNPs minor allele frequency (MAF)≥0.01, which were...

A temperature-controlled electrochemical sensor was constructed based on a composite membrane composed of temperature-sensitive polymer poly (N-isopropylacrylamide) (PNIPAM) and carboxylated multi-walled carbon nanotubes (MWCNTs-COOH). The has good temperature sensitivity reversibility in detecting Dopamine (DA). At low temperatures, the is stretched to bury electrically active sites nanocomposites. cannot exchange electrons through polymer, representing an "OFF" state. On contrary,...

High shear technique coupled with high‐performance counter‐current chromatography was successfully used for the extraction and online isolation of seven highly polar chemical constituents from B rassica napus L . The lower phase ethyl acetate– n ‐butanol–water (1:4:5, v:v:v) as both high solvent mobile phase. Seven compounds 14.2 mg uridine, 4.6 xanthosine, 7.8 guanosine, 5.3 adenosine, 19.5 kaempferol‐3,4'‐di‐ O ‐β‐D‐glucopyranoside, 17.7 kaempferol‐3‐ ‐(2‐...

The animal models were conducted to activity screening of different ethanol fraction from Radix Astragali. Eluted the macroporous adsorptive resins, potential active that had vasodilative effects was isolated and purified by high-speed counter-current chromatography (HSCCC) using gradient elution. solvent system composed chloroform–methanol–acetic acid–water (2 : 1 1, v/v/v/v). flow rate 1.0 mL min−1 initially changed 2.0 at 300 min. Four flavonoids named calycosin-7-O-β- D -glycoside (a),...

Abstract Willow catkin was selected as raw material to fabricated carbon matrix in cathode of lithium‐sulfur (Li−S) battery due its unique tubular morphology. The effects activation time on the microstructure and electrochemical properties were investigated. direct pyrolysis product inherited tube‐like After activated by KOH under high temperature once, microtubes shorten pressed ribbon‐like. Meanwhile abundant micropores formed tube wall. Further activatated twice, original collapsed. Thus...

Many kinds of nanostructured metal oxides were introduced in cathodes Li–S batteries for high sulfur utilization and effective confinement polysulfides. Herein, Gd2O3 nanoparticles modified wave-like carbon host, which are derived from soybean residue by activation pyrolysis processes. After the activated (ASC) host nanoparticles, ASC-Gd was integrated with melting method then used as cathode lithium–sulfur (Li–S) batteries. According to electrochemical results ASC-Gd/S cathode, a initial...

The magnetic molecularly imprinted polymers had been synthesized for the selective extraction and clean-up of 4-methylimidazole in cola, most popular soft beverage. were prepared by means suspension polymerization, using Fe 3 O 4 as magnetically component, template molecule, methacrylic acid functional monomers, ethylene glycol dimethacrylate a cross-linker, initiated 2,2′-azobisisobutyronitrile. obtained characterized scanning electron microscopy, Fourier transform infrared, X-ray...

To investigate the effect of ionic liquids (ILs) as additives to a two-phase solvent system using high-performance counter-current chromatography, two structurally similar flavonoids, Kaempferol-3, 4′-di-O-β-D-glucoside and Kaempferol 3-O-β-D-(2-O-β-D-glucosyl)-glucopyranoside, were chosen models. The effects length alkyl groups on imidazolium ring its counterion, concentrations ILs K values investigated. results showed that target compounds could be improved when used in system. mechanism...

A magnetic carbon nanomaterial for Fe3O4-modified hydroxylated multi-walled nanotubes (Fe3O4-MWCNTs-OH) was prepared by the aggregating effect of Fe3O4 nanoparticles on MWCNTs-OH, and this material combined with high-performance liquid chromatography (HPLC)/photodiode array detector (PAD) to determine strychnine in human serum samples. Some important parameters that could influence extraction efficiency were optimized, including time, amounts Fe3O4-MWCNTs-OH, pH sample solution, desorption...

On the basis of magnetic molecularly imprinted polymer (MMIP) solid-phase extraction coupled with high performance liquid chromatography, we established a new method for determination 4-methylimidazole (4-MEI) in soy sauce. Scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM) were used to characterize synthesized MMIPs. To evaluate polymers, batch rebinding experiments carried out. The binding strength...

Magnetic molecularly imprinted polymer (MMIP) was successfully synthesized with acrylamide as a functional monomer and clenbuterol (CLB) template molecule. The MMIPs were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectrometry (FT-IR). used to identify bind CLB solid phase extraction material. experiment data fitted the Freundlich isotherm adsorption model. results show that have excellent recognition performance for CLB. applied...

Abstract A new sample preparation method of high shear dispersing emulsifier (HSDE) coupled with continuous injection in high-performance counter-current chromatography (HPCCC) was successfully used for the extraction and online isolation caffeine two polyphenolic compounds from green tea. The lower phase hexane-ethyl acetate–methanol–water (1:8:1:8, v/v/v/v) as both HSDE solvent HPCCC mobile phase. In one time loading, 1.5 mg (-)-epicatechin-3-gallate, 5.0 (-)-epigallocatechin-3-gallate,...

High-performance liquid chromatography (HPLC) was employed in a fingerprint analysis of Radix astragali. A characteristic HPLC profile known astragali samples collected from five primary habitats China established by evaluating 15 with chemometric methods, including similarity evaluation, hierarchical cluster (HCA), principal component (PCA) and discriminant (DA). The feasibility advantages employing chromatographic fingerprinting combined methods were investigated demonstrated the...

Background: A simple and effective method to separate chlorogenic acid from Eucommia ulmoides leaves with macroporous resin was studied in this paper. Methods: In order optimize the separation process of leaves, dynamic adsorption desorption experiments were carried out on a glass column filled XDA-8 resin. Based First-principles calculation, possible models simulated. Results: Among six resins, showed good adsorption/desorption capacity high ratio for acid. After being treated once, content...

Background:: Astragalus, as a common traditional Chinese medicine (TCM), has many pharmacological effects, such protection of nerves, heart, blood vessels, kidneys, etc. It can also be used to treat colds, numbness, diarrhea, indigestion, and anemia. Because the current market, there are large number synonyms, multiple sources one medicine. The use near-edge plants in other fake, substandard good phenomenon prevails. Methods:: In this study, method combining electrochemical fingerprinting...

Abstract A nanomaterial comprising Fe 3 O 4 -modified-carboxylic multi-walled carbon nanotubes (Fe -MWCNTs-COOH) was prepared by a co-precipitation method. Combined with HPLC-photodiode array detector (DAD), -MWCNTs-COOH used to determine pigments in beverage. Some important parameters that could influence extraction efficiency were optimized. The results indicated combined HPLC-DAD is promising solid-phase material for the sample pretreatment determination of pigments.