A5053155729- Gallbladder and Bile Duct Disorders
- Microbial Metabolism and Applications
- Enzyme Production and Characterization
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
Gansu Provincial Hospital
2008-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Xi'an Jiaotong University
2023-2024
Shaanxi Provincial People's Hospital
2023-2024
Shanxi Medical University
2023-2024
Lanzhou University
2018-2022
Sichuan University
2011-2021
First Hospital of Lanzhou University
2021
Hunan Normal University
2020
Beijing Children’s Hospital
2016-2019
VEGF receptor 2 (VEGFR2) inhibitors, as efficient antiangiogenesis agents, have been applied in the cancer treatment. However, currently most of these anticancer drugs suffer some adverse effects. Discovery novel VEGFR2 inhibitors drug candidates is still needed.In this investigation, we adopted a restricted de novo design method to inhibitors. We selected potent compound SKLB1002 and analyzed its inhibitory effects on human umbilical vein endothelial cells (HUVEC) vitro. Tumor xenografts...
Background Liver cirrhosis complicated by portal vein thrombosis (PVT) is a fatal complication with no specific manifestations but often misdiagnosed, it crucially increases the mortality worldwide. This study aimed to identify risk factors and establish predictive model for diagnosis of venous clinical routine blood tests endoscopic characteristics.
Class A scavenger receptor member 5 ( SCARA ) is a new of the C lass receptors that has been proposed recently as novel candidate tumor suppressor gene in human hepatocellular carcinoma. In present study, we found expression was frequently downregulated various cancer cell lines and samples. addition, upregulation line (U251) led to significant decrease proliferation, clone formation, migration, invasion vitro . Furthermore, systemic treatment tumor‐bearing mice with SCARA5 –cationic...
Abstract Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation. A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as program death-1 (PD-1/PD-L1) pathway in the tumor environment. However, determinants of response anti-PD-1 monoclonal antibodies (mAbs) treatment remain incompletely understood. In murine models, PD-1 blockade alone fails induce effective...
Abstract Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies advanced our understanding brain pathways involved its development. Particularly, growing evidence points to abnormalities within fronto‐striato‐thalamic pathways. In this study, we combined Tract‐Based Spatial Statistics (TBSS) Atlas‐based regions interest (ROI) analysis approach, investigate...
Abstract Background Although the whole tumor cell vaccine can provide best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete immune activating cytokines have been proved be more IL-18 could augment proliferation T and cytotoxicity NK cells. GM-CSF stimulate dendritic cells, macrophages enhance presentation antigens. In our study, we used mouse combined with modify Lewis lung cancer LL/2, then...
Abstract Accumulating findings reveal that long noncoding RNAs (lncRNAs) as crucial regulatory molecules serve vital functions in the progression of hepatocellular carcinoma (HCC). This study aims to investigate biological roles and mechanisms lncRNA HOXD cluster antisense RNA 1 (HOXD‐AS1) HCC cells based on transcriptome analysis. The Cancer Genome Atlas data analysis experimental validation showed HOXD‐AS1 was increased tissues/cell lines positively relevant histologic grade. subcellular...
Background: The previous works about safety evaluation for constructed bladder tissue specific adenovirus are poorly documented. Thus, we investigated the biodistribution and body toxicity of oncolytic Ad-PSCAE-UPII-E1A (APU-E1A) Ad-PSCAE-UPII-E1A-AR (APU-E1A-AR), providing meaningful information prior to embarking on human clinical trials. Materials Method: Conditionally replicate recombinant (CRADs) APU-E1A, APU-EIA-AR were with UroplakinII(UPII) promoter induce expression Ad5E1A gene...
Survivin, a member of the inhibitor apoptosis protein (IAP) family, is abundantly expressed in variety cancer cells, including lung resulting low sensitivity these cells to various apoptotic stimuli; Cisplatin (CDDP), commonly used chemotherapeutic agent several cancers, has major limitation because its toxicity at high concentration. In present study, we constructed plasmid encoding Survivin shRNA knockdown survivin with dose DDP both vitro and vivo. The specificity potency were validated...