A5100397729- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cardiovascular Health and Risk Factors
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Healthcare Systems and Reforms
- Immune cells in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lung Cancer Treatments and Mutations
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Marine Sponges and Natural Products
- Health Promotion and Cardiovascular Prevention
- Magnolia and Illicium research
- Homelessness and Social Issues
- Synthesis and Biological Evaluation
- Phytochemistry and Bioactive Compounds
- Alcohol Consumption and Health Effects
- Plant-derived Lignans Synthesis and Bioactivity
- Antibiotic Use and Resistance
- Magnetism in coordination complexes
- Esophageal Cancer Research and Treatment
- Lipoproteins and Cardiovascular Health
- Chronic Disease Management Strategies
- Phagocytosis and Immune Regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Hengshui University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Fu Wai Hospital
2024
Sun Yat-sen University
2021-2024
Shanghai Chest Hospital
2023
Shanghai Jiao Tong University
2023
Medical Center Hospital
2022
University of Macau
2021
Peking Union Medical College Hospital
2021
It is estimated that 4 million deaths are due to cardiovascular diseases each year in China. Comprehensive understanding about modifiable risk factors and how the differs across regions needed inform public health policies. We aimed examine geographical profile of disease China.In this study, we analysed data from a nationwide, population-based screening project, which covered 152 rural counties 100 urban districts 31 provinces Between Sept 1, 2015, Nov 30, 2019, standardised measurements...
Neoadjuvant immune checkpoint blockade (ICB) demonstrates promise in operable esophageal squamous cell carcinoma (ESCC), but lacks available efficacy biomarkers. Here, we perform single-cell RNA-sequencing of tumors from patients with ESCC undergoing neoadjuvant ICB, revealing a subset exhausted CD8+ T cells expressing SPRY1 (CD8+ Tex-SPRY1) that displays progenitor (Tpex) phenotype and correlates complete response to ICB. We validate Tex-SPRY1 as an ICB-specific predictor improved survival...
Importance Limited evidence supports the association between low-density lipoprotein cholesterol (LDL-C) and mortality across different atherosclerotic cardiovascular disease (ASCVD) risk stratifications. Objective To explore associations LDL-C levels to identify optimal ranges of with lowest in populations diverse ASCVD profiles. Design, Setting, Participants The ChinaHEART project is a prospective cohort study that recruited residents aged 35 75 years from 31 provinces mainland China...
Journal Article Cohort Profile: ChinaHEART (Health Evaluation And risk Reduction through nationwide Teamwork) Get access Runsi Wang, Wang National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Medications, Fuwai Hospital, Chinese Academy Medical Sciences and Peking Union College, Beijing, People's Republic China Search other works by this author on: Oxford Academic PubMed Google Scholar Yang Yang, Jiapeng Lu, Lu Jianlan Cui, Cui Wei Xu, Xu Lijuan Song, Song...
Targeting the PD‐1/PD‐L1 immune checkpoints has achieved significant positive results in treatment of multiple cancers. Quercetin is one most abundant dietary flavonoids found various vegetables and fruits, a wide range biological activities including immunomodulation. Here we report that quercetin dihydrate was screened shown to inhibit interaction. Treatment with promoted killing activity T cells on MDA‐MB‐231 NCI‐H460 cancer cells. Experiments using xenograft mouse model showed growth...
The advent of immunotherapy has transformed the therapeutic landscape for inoperable, locally advanced Non-Small cell lung cancer (NSCLC), particularly squamous carcinoma (LUSC) with a predominance negative driver genes. Based on results clinical trials such as KEYNOTE-042 and KEYNOTE-407, PD-1/PD-L1 inhibitors are now recognized standard care first-line or second-line treatment in many countries. Among 17 immune checkpoint sanctioned China, tislelizumab, domestically developed PD-1...
Abstract Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation. A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as program death-1 (PD-1/PD-L1) pathway in the tumor environment. However, determinants of response anti-PD-1 monoclonal antibodies (mAbs) treatment remain incompletely understood. In murine models, PD-1 blockade alone fails induce effective...
Currently, a significant proportion of cancer patients do not benefit from programmed cell death-1 (PD-1)-targeted therapy. Overcoming drug resistance remains challenge. In this study, single-cell RNA sequencing and bulk data samples collected before after anti-PD-1 therapy were analyzed. Cell-cell interaction analyses performed to determine the differences between pretreatment responders nonresponders relative in changes posttreatment status ultimately investigate specific mechanisms...
Background Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), as a typical tumor marker, has been found to exert immunomodulatory effects in many diseases. We previously reported the clinical and molecular evidences supporting that SARS-Cov-2 infected gastrointestinal (GI) tract reduction of CEACAM5 COVID-19 patients’ feces which associated with gut dysbiosis. Yet role GI infection is ill-defined. Methods Mice models were established through intraperitoneally injecting...
Abstract Aims We aimed to demonstrate the distribution of alcohol use disorder (AUD) in China and assess its association with quality life mortality. Methods studied 367 120 men aged 35–75 years from 31 provinces Patient-Centered Evaluative Assessment Cardiac Events (PEACE) Million Persons Project. At baseline, AUD was assessed by disorders identification test score, EQ-5D-3L questionnaire used measure life. Mortality data collected via National Surveillance System Vital Registration. Mixed...
A novel complex of nickel(II) picrate (pic) with the V-shaped ligand 2, 6-bis(2-benzimidazolyl) pyridine (bbp) was synthesized and characterized by elemental analysis, electrical conductivity, IR UV/Vis spectral measurements. The crystal structure ([Ni(bbp) 2 ](pic) ·2DMF) has been determined single-crystal X-ray diffraction. Ni(II) cation is bonded to two bbp ligands through six nitrogen atoms, resulting in a distorted octahedral geometry. DNA-binding properties were investigated electronic...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment; however, immune-related adverse events (irAEs) in the gastrointestinal (GI) system commonly occur. In this study, data were obtained from US Food and Drug Administration event reporting between July 2014 December 2020. Colitis, hepatobiliary disorders, pancreatitis identified as irAEs our study. Reporting odds ratio (ROR) with information components (IC) was adopted for disproportionate analysis. A total of 70,330...
TPS3118 Background: EBV associated malignancies exhibits high amplification of PD-L1 as distinguished from non-associated (Kim et al. Gastroenterology 2015; Chen Clinical Cancer Research 2013). The up-regulation restricts antitumor effect EBV-CTLs by immune tolerance and results in poor prognosis patients. Our previous work has generated PD-1-disrupted CTLs CRISPR-Cas9 system which could up-regulate IFN-γ production enhance cytotoxicity tumor cell lines mouse model (Su Oncoimmunology 2016)....
A newly discovered trihydroxynaphthalenone derivative, epoxynaphthalenone (1) involving the condensation of ortho-hydroxyl groups into an epoxy structure, and a novel pyrone metabolite characterized as pyroneaceacid (2), were extracted from Talaromyces purpurpgenus, endophytic fungus residing in Rhododendron molle. The structures these compounds elucidated through comprehensive analysis their NMR HRESIMS data. determination absolute configurations was accomplished using electronic circular...
Background: Contemporary evidence comparing the efficacy of angiotensin-converting enzyme inhibitors (ACEIs) versus angiotensin II receptor blockers (ARBs) on long-term outcomes in patients with hypertension is sparse and inconsistent. The aim to compare effectiveness ACEI monotherapy ARB all-cause death cardiovascular death. Methods: Based a nationwide, population-based prospective cohort project, which covered 318 study sites from 2014 2021 China. Detailed information was collected by...
Aim To evaluate the real-life effectiveness and safety of hydrogen inhalation (HI) therapy as an additional treatment in Chinese adults with hypertension. Methods This observational, retrospective clinical study included hypertensive patients receiving routine antihypertensives or without HI initiation from 2018 to 2023. Participants were assigned group non-HI (control group) after propensity score matching. The changes mean systolic blood pressure (SBP) level during 24-week follow-up period...