A5028770232- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Bauxite Residue and Utilization
- Total Knee Arthroplasty Outcomes
- Geochemistry and Geologic Mapping
- Machine Learning in Bioinformatics
- Epigenetics and DNA Methylation
- Orthopaedic implants and arthroplasty
- Spectroscopy and Chemometric Analyses
- interferon and immune responses
- Artificial Intelligence in Healthcare
- Carbohydrate Chemistry and Synthesis
- Metabolomics and Mass Spectrometry Studies
- Glaucoma and retinal disorders
- Aluminum Alloys Composites Properties
- Intraocular Surgery and Lenses
- Recycling and Waste Management Techniques
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Corneal surgery and disorders
- Machine Learning in Healthcare
- Orthopedic Infections and Treatments
Baylor College of Medicine
2020-2024
Ocean University of China
2024
Wuhu Hit Robot Technology Research Institute
2023
Stevens Institute of Technology
2021-2022
Northeastern University
2021
Jilin Medical University
2020
Jilin University
2020
Abstract Alternative splicing has been shown to causally contribute the epithelial–mesenchymal transition (EMT) and tumor metastasis. However, scope of factors that govern alternative in these processes remains largely unexplored. Here we report identification A-Kinase Anchor Protein (AKAP8) as a regulatory factor impedes EMT breast cancer AKAP8 not only is capable inhibiting activity EMT-promoting regulator hnRNPM through protein–protein interaction, it also directly binds RNA alters...
Objective: A prospective, multicenter, randomized controlled trial was conducted to explore the short-term effect of a new robotic-assisted total knee arthroplasty (TKA) system, and clinical radiographic effectiveness between system conventional TKA were compared analyzed. Materials Methods: Overall, 144 patients randomly divided into two groups, wherein 72 underwent using robotic‑assisted TKA. The demographic data parameters collected. factors influencing postoperative hip–knee–ankle (HKA)...
During breast cancer metastasis, the developmental process epithelial–mesenchymal transition (EMT) is abnormally activated. Transcriptional regulatory networks controlling EMT are well-studied; however, alternative RNA splicing also plays a critical role during this process. A comprehensive understanding of (AS) and binding proteins (RBPs) that regulate it their impact on remains largely unknown. In study, we annotated AS in TCGA data set identified an signature capable distinguishing...
Five new heronamides (1–5) with two unreported 6/6/6/5/5-pentacyclic and 6/9/6/5-tetracyclic skeletons were isolated from deep-sea-derived Streptomyces .
RNA splicing plays a critical role in post-transcriptional gene regulation. Exponential expansion of intron length poses challenge for accurate splicing. Little is known about how cells prevent inadvertent and often deleterious expression intronic elements due to cryptic In this study, we identify hnRNPM as an essential binding protein that suppresses through deep introns, preserving transcriptome integrity. Long interspersed nuclear (LINEs) harbor large amounts pseudo splice sites introns....
DNA methylation is a biological process impacting the gene functions without changing underlying sequence. The machinery usually attaches methyl groups to some specific cytosine residues, which modify chromatin architectures. Such modifications in promoter regions will inactivate tumor-suppressor genes. within coding region may significantly reduce transcription elongation efficiency. function be tuned through cytosines are methylated.This study hypothesizes that overall level across have...
Objective To evaluate the efficacy of femtosecond laser-assisted cataract surgery for treatment high myopia. Methods The data 120 eyes patients with myopia and were collected retrospectively analyzed. Patients randomly divided into two groups: study group, 60 cases, received phacoemulsification intraocular lens implantation; control patients, traditional combined implantation. The follow-up time was 3 months after surgery. Results After BCVA (log MAR) in group 0.32±0.36...