A5053752593- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Gout, Hyperuricemia, Uric Acid
- Birth, Development, and Health
- Heart Rate Variability and Autonomic Control
- Thermography and Photoacoustic Techniques
- Machine Fault Diagnosis Techniques
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Alcohol Consumption and Health Effects
- Cardiovascular Disease and Adiposity
- Pregnancy and Medication Impact
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Health and Disease Prevention
- Child Nutrition and Feeding Issues
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Renal Transplantation Outcomes and Treatments
- Health and Lifestyle Studies
- Non-Destructive Testing Techniques
- Cardiovascular Function and Risk Factors
- Child and Adolescent Health
Instituto de Salud Carlos III
2015-2023
Hospital General Universitario De Valencia
2015-2022
Universitat de València
2014-2021
Ollscoil na Gaillimhe – University of Galway
2019-2021
Centro de Investigación Biomédica en Red
2017-2020
Centro de Investigación Biomédica en Red de Cáncer
2020
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2019
INCLIVA Health Research Institute
2018
Centro de Investigación Biomédica en Red de Salud Mental
2017
Hospital Clínico Universitario de Valencia
2016
Early life is a period of drastic epigenetic remodeling in which the epigenome especially sensitive to extrinsic and intrinsic influence. However, epigenome-wide dynamics DNA methylation changes that occur during this have not been sufficiently characterized longitudinal studies.To end, we studied status more than 750,000 CpG sites using Illumina MethylationEPIC arrays on 33 paired blood samples from 11 subjects at birth 5 10 years age, then chromatin context associated with these loci by...
Previous studies focused on the relationships between Serum Uric Acid (SUA) and lipids have found an association mainly with triglycerides. Furthermore, previous adiposity indices been evaluation of Visceral Adiposity Index (VAI). The present study was aimed at providing within same population a systematic SUA, employing both classic cutoff for hyperuricemia newly one identified by Right Heart Health (URRAH) study. We analyzed data collected in 1892 subjects Pressioni Arteriose Monitorate E...
To identify vascular phenotypes across blood pressure (BP) conditions in overweight and obese youths, by assessing office BP (oBP), central (cBP), pulse (PP) amplification. Whether or not 24-h ambulatory monitoring (ABPM) wave velocity (PWV) add insight to the issue has also been examined.White youths of both sexes with obesity European origin, ranging from 8 18 years age, were included. oBP, cBP, PWV, ABPM measured. oBP 'white-coat' hypertension defined as recommend Society Hypertension...
Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization mortality. As obesity effects on vessels start early in life, even from childhood, it is important health policies to prevent very before manifestation emerge. Key roles prevention strategies increase physical exercise, reduce body weight or treat hypertension, lipids disorders diabetes earlier efficiently complications.
Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD). In the present study, we assessed gender-related relationships between serum uric acid (SUA) cardionephrometabolic variables in central east European hypertensive patients.A total of 3206 treated patients available SUA levels from BP-CARE study was analyzed. Correlations among SUA, BP control, CKD were performed according to gender.Twenty-five...
Observational studies have indicated that high levels of serum uric acid are associated with the risk cardiovascular disease. The aim present study is to investigate association individual cardiometabolic factors, as well their degree clustering, in overweight and moderate obese youth.Three hundred thirty-three Caucasians both sexes (149 women), from 5-18 years age those who underwent an assessment overweight/obesity. Anthropometric parameters, office 24-h blood pressure measurements...
The objective was to assess the differences between 2016 European Society of Hypertension (ESH) and 2017 American Academy Pediatrics (AAP) hypertension (HTN) guidelines in distribution office blood pressure (BP) categories as well ambulatory BP mismatches.The study included 4940 clinical evaluations performed 2957 youth (5-18 years) both sexes. anthropometric parameters were measured following standard conditions. classification measurements normotension, high-normal, stages 1 2 HTN,...
The present prospective study assessed the association of birth weight (BW) and growth pattern on cardiometabolic risk factors in a cohort followed from to 10 years age. One hundred forty-five subjects (73 girls) who fulfilled inclusion criteria had all their data recorded at 5 were enrolled. Of these, 100 (52 also years. Anthropometric measurements, office 24-hour blood pressure, metabolic parameters obtained. At years, both BW current determinants pressure parameters; however, as got...
Early life epigenetic programming influences adult health outcomes. Moreover, DNA methylation levels have been found to change more rapidly during the first years of life. Our aim was identification and characterization CpG sites that are modified with time We hypothesize these changes would lead detection genes might be epigenetically modulated by environmental factors early childhood which, if disturbed, contribute susceptibility diseases later in The study pattern 485577 performed on 30...
The main objective of this cross-sectional study is to assess the cardiac autonomic neural activity in presence abnormally increased body weight youths and its relationship metabolic risk factors cardiorespiratory fitness (CRF).Sixty-four overweight obese patients, aged 9-17 years, both sexes, stratified according international BMI cut-off, were enrolled. Continuous ECG was recorded during 15 min resting conditions, heart rate variability (HRV) measured time domain, frequency domain for...
Electrochemically based technologies are rapidly moving from the laboratory to bedside applications and wearable devices, like in field of cardiovascular disease. Major efforts have focused on biosensor component contrast with those employed creating more suitable detection algorithms for long-term real-world monitoring solutions. The calibration curve procedure presents major limitations this context. objective is propose a new algorithm, compliant current clinical guidelines, which can...
Therapies currently implemented for obesity are focused on nutritional aspects and physical activity. In order to make activity a positive therapy instead of triggering disabilities it is relevant accurately assess cardiovascular fitness.To the fitness by measuring peak oxygen consumption asses their relationship with classical cardiometabolic parameters.A modified Balke protocol was applied one hundred twenty-six Caucasians (60% males), ranging between 9 16 years old, who underwent an...
Obstructive sleep apnea syndrome is a reduction of the airflow during which not only produces in quality but also has major health consequences. The prevalence obese pediatric population can surpass 50%, and polysomnography current gold standard method for its diagnosis. Unfortunately, it expensive, disturbing time-consuming experienced professionals. objective to develop patient-friendly screening tool identify those children at higher risk suffering from this syndrome. Three supervised...
Infrared thermography can be a very useful technique for condition monitoring because the most common faults suffered by induction motors cause temperature rise in motor's frame. Moreover, this is non-intrusive, affordable and sensitive due to substantial technical progress design development of new thermal cameras. However, data interpretation decision making from resulting infrared images one major limitations technique, it directly dependent on operator's experience. Several automated...
Heart rate variability (HRV) monitoring has shown to be promising early diagnose neonatal sepsis and therefore the objective is develop a minimally invasive cost-effective tool, based on HRV machine learning (ML) algorithms, predict risk in neonates within first 48 hours of life. Seventy-nine new-borns, with less than life gestational age between 36 41 weeks, borned Consorci Hospital General Universitari València were enrolled after tutor's authorization. Fifteen them diagnosed sepsis....
Induction motors are the mostly used electric machines in industry, due to their manufacturing features, which makes them more economical and robust. Consequently, it is of special interest identify most common faults present these develop reliable cost-effective diagnostic tools properly maintain them. In this context, infrared thermography coupled with signal processing algorithms can be a very relevant tool. The main objective analyze its potential by focusing on two fault conditions,...
Background: Childhood obesity, including overweight, continues increasing worldwide affecting health expectancy, quality of life and healthcare expenditure. These subjects have higher probability suffering or developing cardio metabolic risk factors. Recent studies revealed cardiorespiratory fitness (CRF) as a valuable clinical parameter to identify these even suggested cut-off values. However, evaluating CRF in overweight obese youth can be difficult implement, unfriendly...
In electrical engineering, the utilization of infrared thermography has been traditionally confined to periodic inspection electric installations, distribution lines and power transformers, among other applications. Over recent years, this technique is being increasingly incorporated in motors predictive maintenance programs. This due fact that it reported its suitability for detecting certain types problems, such as deficient bearing lubrication, cooling system stator winding asymmetries or...