A5049660574- Obesity, Physical Activity, Diet
- Multiple Sclerosis Research Studies
- Physical Activity and Health
- Dental Research and COVID-19
- Cerebral Palsy and Movement Disorders
- Autoimmune and Inflammatory Disorders Research
- Dental materials and restorations
- Behavioral Health and Interventions
- Pediatric Pain Management Techniques
- Health and Lifestyle Studies
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Anesthesia and Pain Management
- Stroke Rehabilitation and Recovery
- Dental Health and Care Utilization
- Medical Device Sterilization and Disinfection
- Dental Education, Practice, Research
- Mental Health and Patient Involvement
- Infection Control in Healthcare
- Meta-analysis and systematic reviews
- Dental Erosion and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Obesity and Health Practices
- Schizophrenia research and treatment
- Geriatric Care and Nursing Homes
University of Exeter
2021-2025
Health & Life (Taiwan)
2025
University of Plymouth
2014-2024
NIHR Exeter Clinical Research Facility
2021-2023
Peninsula College of Medicine and Dentistry
2015-2019
Peninsula College
2016
Government Communications Headquarters
2013
Plymouth Marine Laboratory
2010
Background: People with multiple sclerosis (MS) experience frequent falls, which are associated impairments and limitations to activities participations. Objective: The objective of this paper is evaluate falls risk factors using robust clinical measures. Methods: A total 150 individuals (confirmed MS diagnosis, Expanded Disability Status Scale (EDSS) 3.5–6.5) were recruited, 148 participants included in the final analysis. Demographic data collected performance assessed eight predictor...
Measurement of the faecal markers calprotectin, lactoferrin and tumour M2-PK has been reported to be useful in diagnosis management a range gastrointestinal disorders both children adults. The aim this study was investigate requirement for age-related reference ranges.Faecal samples were obtained from 132 healthy subjects analysis performed using commercially available enzyme-linked immunosorbent assay.In median concentrations as follows: calprotectin - 2-9 y, 34 microg/g, 10-59 22 microg/g...
BackgroundAlthough childhood overweight and obesity prevalence has increased substantially worldwide in the past three decades, scarce evidence exists for effective preventive strategies. We aimed to establish whether a school-based intervention children aged 9–10 years would prevent excessive weight gain after 24 months.MethodsThis pragmatic cluster randomised controlled trial of Healthy Lifestyles Programme (HeLP), prevention intervention, was done 32 schools southwest England. All...
Setting: The study was conducted at Mulago Hospital, Kampala, Uganda. Objective: As chronic respiratory disease (CRD) is a huge, growing burden in Africa, with few available treatments, we aimed to design and evaluate culturally appropriate pulmonary rehabilitation (PR) program Uganda for people post-tuberculosis lung disorder (p-TBLD). Design: In pre–post intervention study, 6-week, twice-weekly PR designed p-TBLD. Outcome measures included recruitment, retention, the Clinical COPD...
Pilates exercise is often undertaken by people with multiple sclerosis (MS) who have balance and mobility difficulties.The primary aim of the study was to compare effects 12 weeks exercises relaxation on mobility. Secondary aims were: (1) standardized (2) exercises.A multicenter, assessor-blinded, randomized controlled trial conducted. Participants Expanded Disability Status Scale scores 4.0 6.5 were randomly allocated groups receiving exercises, or relaxation. Assessments at baseline 16...
Introduction The clinical effectiveness of a ‘rule-out’ acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating single undetectable high-sensitivity cardiac troponin (hs-cTn) taken at presentation, together non-ischaemic ECG, remains unknown. Methods A randomised controlled trial, across eight hospitals in the UK, aimed to establish an hs-cTn and ECG (limit detection discharge (LoDED)) strategy. Eligible adult presented pain; treating clinician...
Current treatments manage symptoms of Parkinson disease (PD), but no known treatment slows progression. Preclinical and epidemiological studies support the potential use statins as disease-modifying therapy.
To estimate the effect of cranial osteopathy on general health and wellbeing, including physical functioning, children with cerebral palsy.Pragmatic randomised controlled trial.142 from Greater London South West England, aged 5-12 years palsy.Participants were to six sessions a registered osteopath or waiting list partial attention control (parents invited participate in two semistructured interviews).Blind assessment motor function by physiotherapists using Gross Motor Function Measure-66...
Background Approximately one-third of children in England leave primary school overweight or obese. There is little evidence effective obesity prevention programmes for this age group. Objective To determine the effectiveness and cost-effectiveness a school-based healthy lifestyles programme preventing aged 9–10 years. Design A cluster randomised controlled trial with an economic process evaluation. Setting Thirty-two schools south-west England. Participants Children Year 5 (aged years) at...
Abstract Introduction A high proportion of patients do not regain outdoor mobility after hip-fracture. Rehabilitation explicitly targeting is needed to enable older adults resume activities that they value most. The aim this study determine the feasibility a randomised, controlled trial intended assess clinical and cost-effectiveness an intervention enabling recovery post hip-fracture (the OUTDOOR intervention). Method multi-centre, parallel group, controlled, trial. Adults 60 years older,...
To assess the behavioural and weight status outcomes in English children a feasibility study of novel primary school-based obesity prevention programme.Exploratory cluster randomised controlled trial Healthy Lifestyles Programme.Four city schools (two control two intervention) South West England.202 aged 9-10 years, whom 193 188 were followed up at 18 24 months, respectively. No child was excluded from study; however, to be eligible, required have least one single Year 5 class.Four-phase...
Haemolysis is defined as the release of cellular components erythrocytes and other blood cells into extracellular space blood. These can cause interference in laboratory measurements, potassium being a commonly measured analyte to be affected. A number factors have been implicated aetiology haemolysis. We undertook this study enable us identify hence rectify causes haemolysis samples from patients on acute medical surgical wards.We performed prospective 353 sampling events during February...
There is a need for greater understanding of the impact multiple sclerosis (MS) from perspective individuals with condition. The South West Impact MS Project (SWIMS) has been designed to improve disease using patient-centred approach. purpose (1) develop improved measurement instruments clinical trials, (2) evaluate longitudinal performance variety patient-reported outcome measures, (3) prognostic predictors use in individualising drug treatment patients, particularly early on course. This...
Abstract Aim To compare levels of periodontitis in non‐smoking type 1 diabetic patients and controls . Material Methods Type patients, aged 20–55 years, were recruited from outpatient clinics at five hospitals Glasgow, UK Control subjects physiotherapy clinics, using the buddy system through an advertisement a free newspaper. The primary outcome was severe defined by clinical attachment level ≥6 mm on ≥1 tooth. Results There 34 well controlled ( HbA1c ≤ 7.5%), 169 poorly 112 non‐diabetic...
BackgroundPeople severely impaired with progressive multiple sclerosis spend much of their day sitting, very few options to improve motor function. As a result, secondary physical and psychosocial complications can occur. Effective feasible self-management strategies are needed reduce sedentary behaviour enhance In this study, we aimed assess the clinical cost effectiveness home-based, self-managed, standing frame programme.MethodsSUMS was pragmatic, multicentre, randomised controlled...
Introduction Parkinson’s disease (PD) is a progressive neurodegenerative condition affecting approximately 185,000 people in the UK. No drug has been proven to slow progression. Epidemiological and pre-clinical data support simvastatin, widely used cholesterol-lowering with well-established safety profile, having neuroprotective properties. The aim of this study (Simvastatin as treatment for PD (PD STAT)) determine whether simvastatin potential part International Linked Clinical Trials...