A5050927522- Hearing Loss and Rehabilitation
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Noise Effects and Management
- Parkinson's Disease Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Nuclear Receptors and Signaling
- Mental Health and Patient Involvement
- Meta-analysis and systematic reviews
- Phonocardiography and Auscultation Techniques
- Educational Environments and Student Outcomes
- Tryptophan and brain disorders
- Subtitles and Audiovisual Media
- Data Analysis with R
- Ginkgo biloba and Cashew Applications
- Cardiac Health and Mental Health
- Musculoskeletal pain and rehabilitation
- Nursing Diagnosis and Documentation
- Infant Development and Preterm Care
- Cerebral Palsy and Movement Disorders
- Pain Management and Placebo Effect
- Data-Driven Disease Surveillance
University of Cambridge
2022-2025
NIHR BioResource
2025
University of Plymouth
2017-2024
Peninsula College of Medicine and Dentistry
2015-2017
Current treatments manage symptoms of Parkinson disease (PD), but no known treatment slows progression. Preclinical and epidemiological studies support the potential use statins as disease-modifying therapy.
<b>Objective</b> To determine whether patient controlled analgesia (PCA) is better than routine care in patients presenting to emergency departments with moderate severe pain from traumatic injuries. <b>Design</b> Pragmatic, multicentre, parallel group, randomised trial. <b>Setting</b> Five English hospitals. <b>Participants</b> 200 adults (71% (n=142) male), aged 18 75 years, who presented the department requiring intravenous opioid for treatment of injuries and were expected be admitted...
Background Identification of permanent hearing impairment at the earliest possible age is crucial to maximise development speech and language. Universal newborn screening identifies majority 1 in 1000 children born with a impairment, but later onset can occur any time there no optimum for further screening. A universal non-standardised school entry (SES) programme place many parts UK its value questioned. Objectives To evaluate diagnostic accuracy tests cost-effectiveness SES UK. Design...
Background Depression and debt are common in the UK. Debt Counselling for Primary Care: an adaptive randomised controlled pilot trial (DeCoDer) aimed to assess clinical effectiveness cost-effectiveness of addition a primary care counselling advice service usual patients with depression debt. However, study was terminated early during internal phase because recruitment delays. This report describes rationale, methods findings study, implications future research. Objectives The overarching aim...
<b>Objective</b> To determine whether patient controlled analgesia (PCA) is better than routine care in providing effective for patients presenting to emergency departments with moderate severe non-traumatic abdominal pain. <b>Design</b> Pragmatic, multicentre, parallel group, randomised trial <b>Setting</b> Five English hospitals. <b>Participants</b> 200 adults (66% (n=130) female), aged 18 75 years, who presented the department requiring intravenous opioid treatment of pain and were...
Recruitment and retention of participants in clinical trials for Parkinson's disease (PD) is challenging. A qualitative study embedded the PD STAT multi-centre randomised controlled trial simvastatin neuroprotection explored motivators, barriers challenges participants, care partners research staff.To outline a set considerations informing patient-centred approach to recruitment, retention, delivery.We performed semi-structured interviews focus groups with subset their partners. Quantitative...
Summary The clinical effectiveness of patient‐controlled analgesia has been demonstrated in a variety settings. However, is rarely utilised the Emergency Department. aim this study was to compare cost‐effectiveness vs. standard care participants admitted hospital from Department with pain due traumatic injury or non‐traumatic abdominal pain. Pain scores were measured hourly for 12 h using visual analogue scale. Cost‐effectiveness as additional cost per hour moderate severe avoided by rather...
The effect of patient-controlled analgesia during the emergency phase care on prevalence persistent pain is unkown. We studied individuals with traumatic injuries or abdominal 6 months after hospital admission via department using an opportunistic observational study design. This was conducted postal questionnaires that were sent to participants recruited multi-centre solutions in setting study. Patients prior chronic states opioid use not studied. Questionnaires included EQ5D, Brief Pain...
Introduction Children with cerebral palsy (CP) frequently undertake physiotherapy programmes to improve walking and balance. They often require adult support exercise in a functional position. A novel interactive trainer has been devised enable children against resistance position, but its efficacy yet be proved. protocol developed determine whether randomised controlled trial (RCT) is feasible. Aim To establish it feasible conduct an RCT assess the effectiveness of 10-week intervention...
This study directly compared the accuracy of two audiometry-based tests for screening school children hearing impairment: currently used test, pure tone screen and a device newly applied to children, HearCheck Screener.Two-gate case-control diagnostic test study.Hearing impaired ('intended cases') aged 4-6 years were recruited between February 2013 August 2014 from collaborating audiology services. Children with no previously identified impairment controls') Foundation Year 1 schools June in...
Objective The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) best managed by reduction or cessation use, but effective treatments are lacking. We tested whether people with AUD admitted to hospital could be recruited retained in a trial Functional Imagery Training (FIT), psychological therapy that uses mental imagery reduce craving. conducted multicentre randomised pilot treatment as usual (TAU) versus FIT+TAU AUD. Design...
Introduction In the UK, alcohol use is main driver of chronic liver disease and each year results in over 1 million unplanned hospital admissions 25 000 deaths from alcohol-related (ArLD). The only effective treatment to prevent progression damage reducing or ceasing consumption. Psychological pharmacological therapies for misuse are ineffective patients with ArLD. Functional imagery training (FIT) a novel psychological therapy that builds on motivational interviewing techniques multisensory...
Objectives & Background The clinical effectiveness of patient controlled analgesia (PCA) has been demonstrated in a variety settings. However, PCA is rarely utilized the emergency department (ED). aim this study was to compare cost versus treatment as usual (TAU) patients admitted ward from ED with pain due traumatic injury or non-traumatic abdominal pain. This cost-effectiveness analysis previously reported PAin SoluTions In Emergency Setting (PASTIES) study. Methods Pain scores were...