A5008589710- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Disease Management Strategies
- Respiratory Support and Mechanisms
- Tuberculosis Research and Epidemiology
- Pediatric Pain Management Techniques
- Multiple Sclerosis Research Studies
- Anesthesia and Pain Management
- Family and Patient Care in Intensive Care Units
- Energy and Environment Impacts
- Delphi Technique in Research
- Air Quality and Health Impacts
- Autoimmune and Inflammatory Disorders Research
- Pain Management and Opioid Use
- Cerebral Palsy and Movement Disorders
- Healthcare Quality and Management
- Patient Satisfaction in Healthcare
- Health and Wellbeing Research
- Child Nutrition and Water Access
- Cardiac Arrest and Resuscitation
- Infectious Diseases and Tuberculosis
- Clinical practice guidelines implementation
- Health, psychology, and well-being
- COVID-19 and Mental Health
- Vascular Anomalies and Treatments
- Alcohol Consumption and Health Effects
NIHR Leicester Biomedical Research Centre
2023-2025
Versus Arthritis
2024
University of Manchester
2024
NIHR Manchester Biomedical Research Centre
2024
University of Leicester
2021-2024
University Hospitals of Leicester NHS Trust
2023-2024
Texas State University
2022
University Hospitals Plymouth NHS Trust
2016-2021
University of Plymouth
2014-2021
Faculty of Public Health
2020
The Valsalva manoeuvre is an internationally recommended treatment for supraventricular tachycardia, but cardioversion rare in practice (5-20%), necessitating the use of other treatments including adenosine, which patients often find unpleasant. We assessed whether a postural modification to could improve its effectiveness.We did randomised controlled, parallel-group trial at emergency departments England. randomly allocated adults presenting with tachycardia (excluding atrial fibrillation...
<h3>AIM</h3> To investigate the performance of routine neonatal and 6 week examinations for detecting congenital heart disease. <h3>METHODS</h3> A retrospective review findings on clinical examination was conducted a cohort live born infants with disease in one health region 1987–94 <h3>RESULTS</h3> Of 1590 babies disease, 523 (33%) presented before because symptoms or non-cardiac abnormalities. 1061 underwent which abnormal 476 (45%), but only 170 were referred directly diagnosis. 876...
Setting: The study was conducted at Mulago Hospital, Kampala, Uganda. Objective: As chronic respiratory disease (CRD) is a huge, growing burden in Africa, with few available treatments, we aimed to design and evaluate culturally appropriate pulmonary rehabilitation (PR) program Uganda for people post-tuberculosis lung disorder (p-TBLD). Design: In pre–post intervention study, 6-week, twice-weekly PR designed p-TBLD. Outcome measures included recruitment, retention, the Clinical COPD...
To assess the short term health effects of improving housing.Randomised to waiting list.119 council owned houses in south Devon, UK.About 480 residents these houses.Upgrading (including central heating, ventilation, rewiring, insulation, and re-roofing) two phases a year apart.All completed an annual questionnaire: SF36 GHQ12 (adults). Residents reporting respiratory illness or arthritis were interviewed using condition-specific questionnaires, former also completing peak flow symptom...
To estimate the effects of medical audit, particularly setting clinical standards, on general practitioners' behaviour.Before and after study strengthened by a replicated Latin square.62 training practices in north England.92 practitioner trainers, 84 (91%) whom completed study; random sample 3500 children consulting one these trainers for any five conditions--acute cough, acute vomiting, bedwetting, itchy rash, recurrent wheezy chest--stratified doctor consulted, condition, age.Clinical...
<b>Objective</b> To determine whether patient controlled analgesia (PCA) is better than routine care in patients presenting to emergency departments with moderate severe pain from traumatic injuries. <b>Design</b> Pragmatic, multicentre, parallel group, randomised trial. <b>Setting</b> Five English hospitals. <b>Participants</b> 200 adults (71% (n=142) male), aged 18 75 years, who presented the department requiring intravenous opioid for treatment of injuries and were expected be admitted...
Abstract The objective was to evaluate the effectiveness and acceptability of locally tailored implementation improved cookstoves/heaters in low- middle-income countries. This interventional study among 649 adults children living rural communities Uganda, Vietnam Kyrgyzstan, performed after situational analyses awareness programmes. Outcomes included household air pollution (PM 2.5 CO), self-reported respiratory symptoms (with CCQ MRC-breathlessness scale), chest infections, school absence...
A 48-yr-old female on immunosuppressive therapy for fibrosing alveolitis and polymyositis developed a septic arthritis of the left middle finger proximal interphalangeal joint, tenosynovitis palm osteomyelitis right hindfoot due to infection with Mycobacterium marinum. Such widespread severe bone joint involvement has not been described previously this organism.
<b>Objective</b> To determine whether patient controlled analgesia (PCA) is better than routine care in providing effective for patients presenting to emergency departments with moderate severe non-traumatic abdominal pain. <b>Design</b> Pragmatic, multicentre, parallel group, randomised trial <b>Setting</b> Five English hospitals. <b>Participants</b> 200 adults (66% (n=130) female), aged 18 75 years, who presented the department requiring intravenous opioid treatment of pain and were...
The most common physical deficit caused by a stroke is muscle weakness which limits person's mobility. Mobility encompasses activities necessary for daily functioning: getting in and out bed, on/off toilet, sitting, standing walking. These are significantly affected people with severe who typically spend of their time bed or chair immobile. Immobility primarily neurological damage but exacerbated secondary changes musculoskeletal cardiorespiratory systems. can theoretically be prevented...
Background A randomized study of the effect on people's health improving their housing is underway in Torbay. The link between poor health, particularly respiratory and conditions has been recognized for a long time, but there have few intervention studies to demonstrate that can improve health. In 1994, South West Devon Health Authority set up community development project deprived area Torbay, response concerns local primary health‐care workers. worker helped residents survey homes...
Introduction: Pulmonary rehabilitation (PR) is a low cost, high impact intervention that ameliorates the disability associated with chronic respiratory diseases (CRD). PR becoming increasingly recognized in resource settings where burden of CRD rapidly increasing. To aid implementation Uganda, we conducted study to assess attitudes and opinions towards among patients Uganda explore barriers faced by health care workers (HCWs) referring PR. Methods: A cross-sectional comprising two survey...
Pulmonary arterial hypertension (PAH) is an uncommon condition with progressive heart failure and premature death. Treatment costs up to £120,000 per patient year, the psychological burden of PAH substantial. Mindfulness-based stress reduction (MBSR) intervention potential reduce this burden, but date, it has not been applied people pulmonary hypertension. We wished determine whether a trial MBSR for would be feasible. A customised gentle programme eight sessions was developed physical...
After experiencing tuberculosis (TB), many people develop post-tuberculosis lung disease (PTBLD). Pulmonary rehabilitation (PR) centrally comprising of education and exercise is recommended internationally for living with chronic respiratory diseases. However, no such service exists in Kyrgyzstan. This study investigated the opinions healthcare professionals who would be expected to potential future referrers PR adults PTBLD about what a programme could look like Kyrgyzstan.A qualitative...
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, corresponding to 5% all deaths globally, with more than 90% occurring in low- and middle-income countries (LMIC). Pulmonary Rehabilitation (PR) a routine clinical service for COPD management, often used western countries. At present, there no formal PR Sri Lanka; culturally appropriate programme required that considers views adults living healthcare providers (HCPs) who would be involved...
The Valsalva manoeuvre (VM) is a recommended first-line physical treatment for patients with re-entrant supraventricular tachycardia (SVT), but often ineffective in standard practice. A failed VM typically followed by intravenous adenosine, which find unpleasant. effectiveness might be improved modification to posture exaggerates the manoeuvre's vagal response and reduces need further emergency treatment.
Background Balance, mobility impairments and falls are common problems for people with multiple sclerosis (MS). Our ongoing research has led to the development of Balance Right in MS (BRiMS), a 13-week home- group-based exercise education programme intended improve balance encourage safer mobility. Objective This feasibility trial aimed obtain necessary data operational experience finalise planning future definitive multicentre randomised controlled trial. Design Randomised Participants were...