A5010379401- Dementia and Cognitive Impairment Research
- Rheumatoid Arthritis Research and Therapies
- Energy and Environment Impacts
- Systemic Lupus Erythematosus Research
- Frailty in Older Adults
- Spondyloarthritis Studies and Treatments
- Air Quality and Health Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Child Nutrition and Water Access
- Chronic Disease Management Strategies
- T-cell and B-cell Immunology
- Global Public Health Policies and Epidemiology
- Parvovirus B19 Infection Studies
- Pharmaceutical Practices and Patient Outcomes
- Meta-analysis and systematic reviews
- Immunotherapy and Immune Responses
- Facial Trauma and Fracture Management
- Health Promotion and Cardiovascular Prevention
- Monoclonal and Polyclonal Antibodies Research
- Traumatic Ocular and Foreign Body Injuries
- Health, psychology, and well-being
- Diet and metabolism studies
- Historical and modern epidemiology studies
- Bartonella species infections research
- Autophagy in Disease and Therapy
University of Crete
2014-2024
University Hospital of Heraklion
2023-2024
Several population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden island of Crete during 1999-2013.Multisource case-finding included patients ≥15 years old. Cases were ascertained by ACR 1997, SLICC 2012 criteria rheumatologist diagnosis, validated through synthesis medical charts, administrative patient-generated data.Overall...
Background Characterisation of the long-term outcome patients with ‘difficult to treat’ (D2T) rheumatoid arthritis and factors contributing its evolution are unknown. Herein, we explored heterogeneity D2T outcome. Methods Patients included from a prospective single centre cohort study. The EULAR definition was applied. Longitudinal clustering functional status (modified Health Assessment Questionnaire (mHAQ)) disease activity (Disease Activity Score-28 (DAS28)) were assessed using...
Objective To obtain real-world data on outcomes of belimumab treatment and respective prognostic factors in patients with systemic lupus erythematosus (SLE). Methods Observational study 188 active SLE (median disease duration 6.2 years, two previous immunosuppressive/biological agents) treated belimumab, who were monitored for SLEDAI-2K, Physician Global Assessment (PGA), LLDAS (lupus low activity state), remission (DORIS/Padua definitions), SELENA-SLEDAI Flare Index, SLICC/ACR damage index...
Individuals with schizophrenia spectrum disorders use the Internet for general and health-related purposes. Their ability to find, understand, apply health information they acquire online in order make appropriate decisions - known as eHealth literacy has never been investigated. The European agenda strives limit inequalities enhance mental literacy. Nevertheless, each member state varies levels of information-seeking. This study aimed examine computer/Internet purposes, literacy, attitudes...
Abstract The objective was to evaluate the effectiveness and acceptability of locally tailored implementation improved cookstoves/heaters in low- middle-income countries. This interventional study among 649 adults children living rural communities Uganda, Vietnam Kyrgyzstan, performed after situational analyses awareness programmes. Outcomes included household air pollution (PM 2.5 CO), self-reported respiratory symptoms (with CCQ MRC-breathlessness scale), chest infections, school absence...
Our aim was to explore the burden of dementia in Cretan Aging Cohort, comprised 3140 persons aged ≥60 years (56.8% women, 5.8 ± 3.3 formal education, 86.2% living rural areas) who attended selected primary health-care facilities on island Crete, Greece. In first study phase, a diagnosis had been reached 4.0% participants. However, when 505 participants underwent thorough neuropsychiatric evaluation second phase this (344 with Mini-Mental State Examination [MMSE] <24 and 161 MMSE ≥24),...
Irrational prescribing of over-the-counter (OTC) medicines in general practice is common Southern Europe. Recent findings from a research project funded by the European Commission (FP7), "OTC SOCIOMED", conducted seven countries, indicate that physicians countries Mediterranean Europe region prescribe to higher degree comparison other participating countries. In light these findings, feasibility study has been designed explore acceptance pilot educational intervention targeting various...
Community-acquired pneumonia (CAP) is a potentially life-threatening condition that often requires hospitalisation particularly in the elderly population or patients with comorbidities. The aims of this study were to estimate CAP frequency and severity well-defined primary healthcare setting rural Crete, record patient characteristics, their immunisation status determinants. An observational was designed implemented within prefecture Heraklion island Greece. Eligible those aged 50 years...
What is known and objective Polypharmacy has a significant impact on patients' health with overall expenditure over-the-counter (OTC) medicines representing substantial burden in terms of cost treatment. The aim this study, which was conducted within the framework European Project funded by Union under Seventh Framework Programme entitled OTC-SOCIOMED, to report possible determinants patient behaviour regarding consumption medicines, particularly OTCs, context primary care. Methods A...
Background: Under conditions of high demand for primary care services in a setting low financial resources, there is need brief, easily administered cognitive screening tools use the setting, especially rural areas. However, interpretation these tests' results requires knowledge on their susceptibility to cultural, educational and demographic patient characteristics.Objectives: To assess clinical validity 'Test Your Memory' (TYM) 'General Practitioner assessment Cognition' (GPCog) which was...
Abatacept (CTLA4-Ig)—a monoclonal antibody which restricts T cell activation—is an effective treatment for rheumatoid arthritis (RA). Nevertheless, only 50% of RA patients attain clinical responses, while predictors response are rather limited. Herein, we aimed to investigate early biomarkers abatacept, based on a detailed immunological profiling peripheral blood (PB) cells and serum proteins. We applied flow cytometry proteomics analysis PB immune respectively, starting abatacept as the...
The beneficial effects of traditional herbs Crete, Greece for the treatment upper respiratory tract infections have been reported in observational and laboratory studies. Following a published, double blind, randomized, placebo controlled trial, this study aimed to assess effectiveness an extract three Cretan on infections, upon its market release. An was conducted Heraklion, Greece. Participants were patients presenting at selected pharmacies with symptoms infection, choosing receive their...
Abstract Most patients with chronic respiratory disease live in low-resource settings, where evidence is scarcest. In Kyrgyzstan and Vietnam, we studied the implementation of a Ugandan programme empowering communities to take action against biomass tobacco smoke. Together local stakeholders, co-created train-the-trainer design integrated into existing health infrastructures. Feasibility acceptability, evaluated by modified Conceptual Framework for Implementation Fidelity , were high: reached...
Abstract Background Rituximab is used for the treatment of active rheumatoid arthritis. In present study, we examined long-term flare risk and safety reduced doses rituximab. Patients-methods This was a prospective, observational, single-center study patients starting rituximab on standard dose (SD). Patients were switched to low (LD) (1 g every 6 months), based treating rheumatologist’s decision after having achieved sustained clinical responses, while rest continued During 60-month period,...
Introduction: Dementia severely affects the quality of life patients and their caregivers; however, it is often not adequately addressed in context a primary care consultation, especially with multi-morbidity. Study Population Methods: A cross-sectional study was conducted between March-2013 December-2014 among 3,140 consecutive aged >60 years visiting 14 health practices Crete, Greece. The Mini-Mental-State-Examination [MMSE] used to measure cognitive status using conventional 24-point...
Eye injuries are a major cause of visual disability worldwide and may present burden to both quality life the sufferers healthcare services. The aim this study was extract triangulate information on demographic, clinical, social features eye-injured adult patients admitted tertiary hospital in Greece. design five-year retrospective patients, General University Hospital Heraklion, Crete (GUHH), single referral island. Drawing profile add future health planning. Data collected from 1 January...