Summary The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk dementia. Identifying factors that may contribute to the progress MCI dementia critical. objective this study was examine association sleep performance in patients. A subsample 271 participants diagnosis probable Alzheimer's disease (AD; N = 50) or (MCI; 121) 100 persons who were not cognitively impaired (NI) recruited from large population‐based cohort island Crete,...

Patients with dementia report excessive daytime sleep/sleepiness, which is associated worse cognitive performance. Inflammatory markers may be elevated in patients and have been proposed as mediators of sleep/sleepiness.To examine the association objective napping performance peripheral inflammation compared to not cognitively impaired (NCI) controls.A sub-sample 46 mild-to-moderate 85 NCI controls, were recruited from a large, population-based cohort 3,140 elders (≥60 years) Crete, Greece....

Apolipoprotein E gene (APOE) ɛ4 allele increases the risk for Alzheimer's disease (AD). Furthermore, among patients with cognitive impairment, longer sleep duration is associated worse performance. To date, literature examining associations between APOE and objective limited.Our aim was to assess association duration, mild impairment (MCI) AD. A sub-sample of 89 AD (n = 49) MCI 40) were recruited from a large, population-based cohort 3,140 elders (>60 years) residing on Crete, Greece.All...

There is growing evidence that high basal cortisol levels and systemic inflammation independently contribute to cognitive decline among older people without dementia. The present cross-sectional study examined (a) the potential synergistic effect of on executive function (b) whether this more prominent with mild impairment (MCI). A sub-sample 99 patients MCI 84 (CNI) (aged 73.8 ± 7.0 years) were recruited from a large population-based cohort in Crete, Greece, underwent comprehensive...

Although the link between sleep and memory function is well established, associations macrostructure in normal cognition Mild Cognitive Impairment remain unclear. We aimed to investigate longitudinal of baseline objectively assessed quality duration, as time bed, with verbal capacity over a 7-9 year period. Participants are well-characterized subsample 148 persons (mean age at baseline: 72.8 ± 6.7 years) from Cretan Aging Cohort. Based on comprehensive neuropsychiatric neuropsychological...

It has been shown that inflammatory markers are elevated in patients with cognitive impairment and also associated excessive daytime sleepiness (EDS). In addition, we have previously Dementia sleep longer. The aim of this study was to test the hypothesis objective nighttime is inflammation among Dementia. A sub-sample 53 Dementia, were recruited from a large, population-based cohort island Crete, Greece 3140 older adults (>60yrs). overall goal assess prevalence risk factors impairment. All...

Anorexia nervosa (AN), rare in young men, is potentially associated with severe medical complications. Mild liver involvement common. However, cases of dysfunction AN have been described. To present a rare, case an adult male AN. Describe uncommon, lethal, complications dysfunction. medical/psychiatric presentation, course disease and interventions during hospitalization follow-up. Male 35 y.o. for 20 years (purging type use diuretics/ laxatives intensive exercise) was transferred...

The psychological consequences on the caregivers taking care of mentally ill patients are well known; however, little evidence exists as to whether a patient affects physical health caregiver. To examine effect caregiving emotional and health. study association between for illness. One hundred twenty-eight caregivers, relatives suffering from schizophrenia or bipolar disorder, who were hospitalized consecutively during past three years (2011–2013), 117 controls completed over telephone...

Recently, suicides in Greece, have drawn national and international interest due to the current economic crisis. According published reports, Greece increased up 40%. Specifically, lay press has highlighted Crete as an area with sharpest increase of Greece. To explore whether crisis is associated suicide rates Crete. investigate between 1999-2011. Data on were selected from Department Forensic Medicine files University Hospital Heraklion/Crete, well Files Our analysis showed that during...

Deinstitutionalization in Crete, as part of the psychiatric reform, resulted closure only hospital island 2006. To explore trends yearly involuntary admissions Psychiatric Department University Hospital Crete (PD/UHC) (2008-2011), inpatient public unit to receive a region 400,000 residents, and profile patients admitted. find possible associations between number admissions. We examined records total PD/UHC 2008–2011. In subset 400 inpatients admitted Nov/2011 Aug/2012,...

It has been shown that inflammatory markers are elevated in patients with cognitive impairment and associated excessive daytime sleepiness (EDS). Furthermore, we have previously extended sleep/sleepiness Mild Cognitive Impairment (MCI) is impaired performance. The aim of this study was to assess the associations between inflammation, objective sleep, cognition among MCI. A sub-sample 119 MCI were recruited from a large, population-based cohort island Crete, Greece 3140 older adults (>60yrs)....

Apolipoprotein E gene (APOE) ε4 allele increases the risk for Alzheimer’s Disease (AD). We have previously shown that among cognitively non-impaired elderly and patients with cognitive impairment, longer sleep duration is associated worse performance. To date, only two pilot studies examined associations between APOEε4 objective in healthy impaired findings were inconsistent. Our aim was to assess association sleep, controls Mild Cognitive Impairment (MCI) AD. A sub-sample of 161 MCI (n=38),...

It has been reported that patients with Dementia are sleepier and daytime sleepiness is associated worse cognitive performance. Inflammatory markers may be elevated in impairment have proposed as mediators of excessive (EDS). The aim this large, controlled study was to examine the association performance peripheral inflammation dementia. A sub-sample 46 mild-to-moderate [mean age:80.3 (SD=5.6) years, 40% males] 85 cognitively intact controls(NI) age :73.0(SD=7.4) 37% males], were recruited...

Abstract Introduction Insomnia short sleep phenotype is associated with cardiometabolic morbidity and mortality neuropsychological impairment. In elderly untreated insomnia worse cognitive performance. The goal of the study was to examine association between insomnia, objective duration physical mental health in patients Mild Cognitive Impairment (MCI). Methods A sub-sample 105 MCI (mean age: 75.9 years, males 36%) were recruited from a large population-based cohort (Cretan Aging Cohort)...

Abstract Introduction Previous research reports an inverse U-curve association between subjective sleep duration and cognition in elderly, while findings on objective are inconsistent. Only one study found weak short cognition, mainly driven by demented elders. Our aim was to examine the non-linear associations cognitive performance among community-dwelling patients with dementia. Methods A sub-sample of 46 mild-to-moderate dementia(AD) [mean age: 80.3 (SD=5.6) years, 40% males] 85...