A5044837504- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Inhalation and Respiratory Drug Delivery
- Delphi Technique in Research
- Diagnosis and treatment of tuberculosis
- Chronic Disease Management Strategies
- Music Therapy and Health
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- COVID-19 Impact on Reproduction
- Child Nutrition and Water Access
- Emergency and Acute Care Studies
- Public Health and Nutrition
- Health Systems, Economic Evaluations, Quality of Life
- Energy and Environment Impacts
- Interprofessional Education and Collaboration
- Infectious Diseases and Tuberculosis
- HIV/AIDS Impact and Responses
Makerere University
2017-2024
Lung Institute
2020-2024
Mulago Hospital
2020-2024
MUJHU Research Collaboration
2010-2021
Infectious Diseases Research Collaboration
2017-2018
University of California, San Francisco
2010-2016
Rationale The clinical impact of Xpert MTB/RIF for tuberculosis (TB) diagnosis in high HIV-prevalence settings is unknown. Objective To determine the diagnostic accuracy and among high-risk TB suspects. Methods We prospectively enrolled consecutive, hospitalized, Ugandan suspects two phases: baseline phase which results were not reported to clinicians an implementation reported. determined reference culture (solid liquid) compared patient outcomes by study phase. Results 477 patients...
Setting: The study was conducted at Mulago Hospital, Kampala, Uganda. Objective: As chronic respiratory disease (CRD) is a huge, growing burden in Africa, with few available treatments, we aimed to design and evaluate culturally appropriate pulmonary rehabilitation (PR) program Uganda for people post-tuberculosis lung disorder (p-TBLD). Design: In pre–post intervention study, 6-week, twice-weekly PR designed p-TBLD. Outcome measures included recruitment, retention, the Clinical COPD...
Detailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited.We determined clinical treatment diagnosed Uganda.As 16 May 2020, a total 203 cases had been confirmed. We report first 56 patients; 29 received hydroxychloroquine (HCQ) 27 did not. Endpoints included admission to intensive care, mechanical ventilation or death during hospitalisation.The median age was 34.2 years; 67.9% were male; 14.6% <18 years. Up 57.1% asymptomatic. The most...
Recent large-scale population data on the prevalence of asthma and its risk factors are lacking in Uganda. This survey was conducted to address this gap.A general based among people ≥12 years. A questionnaire used collect participants socio-demographics, respiratory symptoms, medical history, known factors. Participants who reported wheeze past 12 months, a physician diagnosis or current use medications were classified as having asthma. Asthmatics ≥ 35 years underwent spirometry determine...
Convalescent plasma (CCP) has been studied as a potential therapy for COVID-19, but data on its efficacy in Africa are limited.In this trial we set out to determine the of CCP treatment COVID-19 Uganda.Patients with positive SARS-CoV-2 reverse transcriptase (RT)-PCR test irrespective disease severity were hospitalised and randomised receive either plus standard care (SOC) or SOC alone. The primary outcome was time viral clearance, defined having two consecutive RT-PCR-negative tests by day...
Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa unknown.
Equitable access to affordable medicines and diagnostic tests is an integral component of optimal clinical care patients with asthma chronic obstructive pulmonary disease (COPD). In Uganda, we lack contemporary data about the availability, cost affordability essential in COPD management. Data on 17 2 management were collected from 22 public hospitals, 23 private 85 pharmacies. The percentage available tests, median retail price lowest priced generic brand terms number days' wages it would...
Background Hypertension accounts for more than 212 million global disability-adjusted life-years, and 15 in sub-Saharan Africa. Identifying factors underlying the escalating burden of hypertension Africa may inform delivery targeted public health interventions. Methods As part cross-sectional nationally representative Uganda National Asthma Survey conducted 2016, we measured blood pressure (BP) general population across five regions Uganda. We defined as systolic BP ≥140 mmHg and/or...
Data on asthma treatment outcomes in Africa are limited. 449 patients with (age 5-93 years) Uganda were followed up for 2 years to determine rates of exacerbations and mortality associated factors. During follow-up the median number per patient was 1 (IQR 0-5) 17 died (3.7%, 27.3 deaths 1000 person years). Considering only first year follow-up, 59.6% experienced at least one exacerbation, 32.4% three or more exacerbations. A multivariable model showed that likelihood experiencing...
Abstract The objective was to evaluate the effectiveness and acceptability of locally tailored implementation improved cookstoves/heaters in low- middle-income countries. This interventional study among 649 adults children living rural communities Uganda, Vietnam Kyrgyzstan, performed after situational analyses awareness programmes. Outcomes included household air pollution (PM 2.5 CO), self-reported respiratory symptoms (with CCQ MRC-breathlessness scale), chest infections, school absence...
Background: We examined the effect of physical position on peak inspiratory flow (PIF) in patients with chronic obstructive pulmonary disease (COPD) using dry powder inhalers (DPIs) low-medium (R2) and/or high (R5) internal resistance.Methods: This prospective study stable, ambulatory spirometry-confirmed COPD evaluated three positions maximal PIF achieved.Participants had 30-90 L/min or 60-90 (R2 DPIs) In-Check™ DIAL.PIF was measured triplicate randomly that might be while their inhaler...
Smear-positive tuberculosis (TB) case detection rates are far below targets in most low-income countries. The standard approach to smear microscopy involves sputum collection over multiple days and examination of smears by light (LM), an insensitive time-consuming technique.To determine whether two alternative approaches can increase smear-positive increasing the efficiency (single-specimen microscopy) or sensitivity (light-emitting diode [LED] fluorescence [FM]) TB suspect evaluation.We...
In 2007, World Health Organization (WHO) issued emergency recommendations on empiric treatment of sputum acid-fast bacillus smear-negative patients with possible tuberculosis (TB) in HIV-prevalent areas, and called for operational research to evaluate their effectiveness. We sought determine if early, TB abnormal chest radiography or severe illness as suggested by the 2007 WHO guidelines, is associated improved survival.We prospectively enrolled consecutive HIV-seropositive inpatients at...
Purpose: Chronic respiratory disease (CRD) including COPD carries high and rising morbidity mortality in Africa, but there are few available treatments. Pulmonary rehabilitation (PR) is a non-pharmacological treatment with proven benefits improving symptoms exercise capacity, which has not been tested Africa. We aimed to evaluate the lived experience of people CRD, physical psychosocial impacts, how these addressed by PR. Patients methods: A team specialists, nurses, physiotherapists...
Albert Einstein taught us that “everything is relative.” People’s experience of physical activity (PA) no different, with “relativism” particularly pertinent to the perception intensity. Markers absolute and relative intensities PA have different but complimentary utilities, intensity considered best for guideline adherence personalized exercise prescription. Under paradigm as medicine, our Technical Note proposes a method synchronizing accelerometry incremental shuttle walking test...
Multimorbidity is an emerging challenge for health systems globally. It commonly defined as the co-occurrence of two or more chronic conditions in one person, but its meaning remains a lively area academic debate, and utility concept beyond high-income settings uncertain. This article presents findings from interdisciplinary research initiative that drew together 60 applied partners working 10 African countries to answer questions: how useful multimorbidity within Africa? Can be adapted...
Rationale The relationship between clinical and biomarker characteristics of asthma its severity in Africa is not well known. Methods Using the Expert Panel Report 3, we assessed for with key phenotypic Uganda, Kenya Ethiopia. included adult onset asthma, family history exposures (smoking biomass), comorbidities (HIV, hypertension, obesity, tuberculosis (TB), rhinosinusitis, gastro-oesophageal disease (GERD) biomarkers (fractional exhaled nitric oxide (FeNO), skin prick test (SPT) blood...
Introduction Music and dance are increasingly used as adjunctive arts-in-health interventions in high-income settings, with a growing body of research suggesting biopsychosocial benefits. Such low-cost, low-resource may have application settings such Uganda. However, on perceptions patients healthcare professionals regarding approaches is lacking. Methods We delivered sample sessions music for chronic respiratory disease (CRD) to professionals. Seven participants took part one singing...
Introduction: Pulmonary rehabilitation (PR) is a low cost, high impact intervention that ameliorates the disability associated with chronic respiratory diseases (CRD). PR becoming increasingly recognized in resource settings where burden of CRD rapidly increasing. To aid implementation Uganda, we conducted study to assess attitudes and opinions towards among patients Uganda explore barriers faced by health care workers (HCWs) referring PR. Methods: A cross-sectional comprising two survey...
HIV and asthma are highly prevalent diseases in Africa but few studies have assessed the impact of on prevalence high burden settings. The objective this analysis was to compare among persons living with (PLHIV) those without participating Uganda National Asthma Survey (UNAS).UNAS a population-based survey aged ≥12 years. diagnosed based either self-reported current wheeze concurrently or within prior 12 months; physician diagnosis; use medication. defined confidential self-report. We used...
Approaches to screening for active tuberculosis (TB) among people living with HIV are inadequate, leading missed diagnoses and poor implementation of preventive therapy.Consecutive HIV-infected adults hospitalized at Mulago Hospital (Kampala, Uganda) between June 2011 July 2013 a cough ≥ 2 weeks were enrolled. Patients underwent extensive evaluation pulmonary TB. Concentrations 43 cytokines/chemokines measured the same time point as C-reactive protein (CRP) in banked plasma samples using...