A5083203354- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Chronic Disease Management Strategies
- Tuberculosis Research and Epidemiology
- Airway Management and Intubation Techniques
- Emergency and Acute Care Studies
- Viral Infections and Outbreaks Research
- Bacterial Infections and Vaccines
- COVID-19 epidemiological studies
- Healthcare Systems and Reforms
- Ethics in Clinical Research
- Cardiac, Anesthesia and Surgical Outcomes
- Immune responses and vaccinations
- COVID-19 diagnosis using AI
- Respiratory Support and Mechanisms
- Global Maternal and Child Health
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Nosocomial Infections in ICU
- Health Systems, Economic Evaluations, Quality of Life
- Ultrasound in Clinical Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Liverpool
2015-2025
Liverpool School of Tropical Medicine
2015-2025
Aintree University Hospitals NHS Foundation Trust
2015-2025
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2020-2024
Kamuzu University of Health Sciences
2022-2024
Université de Lorraine
2023
Leiden University Medical Center
2023
Queen Elizabeth Central Hospital
2020-2022
University of Health and Allied Sciences
2022
University of Surrey
2022
Despite the acknowledged injustice and widespread existence of parachute research studies conducted in low- or middle-income countries by researchers from institutions high-income countries, there is currently no pragmatic guidance for how academic journals should evaluate manuscript submissions challenge this practice. We assembled a multidisciplinary group editors with expertise international health to develop consensus statement. reviewed relevant existing literature held three workshops...
Abstract Background We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory emerging Infection Consortium (ISARIC) COVID-19 cohort, one of world's largest international, standardized data sets concerning hospitalized patients. Methods The set analysed includes patients between January 2020 2022 52 countries. investigated how symptoms on admission, co-morbidities, risk factors varied by age, sex other characteristics. used Cox...
Rationale: Neutrophil extracellular traps (NETs) are important in the host defense against infection, but they also promote intravascular coagulation and multiorgan failure animal models. Their clinical significance remains unclear, available assays for patient care lack specificity reliability.Objectives: To establish a novel assay test its significance.Methods: A prospective cohort of 341 consecutive adult ICU patients was recruited. The NET-forming capacity admission blood samples...
New vaccines are urgently needed to protect the vulnerable from bacterial pneumonia. Clinical trials of pneumonia slow and costly, requiring tens thousands patients. Studies pneumococcal vaccine efficacy against colonization have been proposed as a novel method down-select between candidates.Using our safe reproducible experimental human model, we aimed determine effect 13-valent conjugate (PCV) on colonization.A total 100 healthy participants aged 18-50 years were recruited into this...
In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing socioeconomic constraints, leading predictions that the COVID-19 pandemic would progress rapidly. However, due limited capacity test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of true burden infection and death. We, therefore, conducted SARS-CoV-2 serosurvey amongst care...
The National Institute for Clinical Excellence in the UK has issued guidelines stating all individuals with epilepsy be given information about sudden unexpected death (SUDEP).We conducted a survey of current practice among neurologists, using questionnaire sent to practising neurologists listed on Association British Neurologists database, asking under what circumstances they told patients SUDEP.Of validated respondents, 5% discussed SUDEP patients, 26% majority, 61% few, and 7.5% none....
<ns4:p><ns4:bold>Background</ns4:bold>: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing socioeconomic constraints, leading predictions that the COVID-19 pandemic would progress rapidly. However, due limited capacity test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of true burden infection and death. We, therefore, conducted...
Abstract Background Compared to the abundance of clinical and genomic information available on patients hospitalised with COVID-19 disease from high-income countries, there is a paucity data low-income countries. Our aim was explore relationship between viral lineage patient outcome. Methods We enrolled prospective observational cohort adult PCR-confirmed July 2020 March 2022 Blantyre, Malawi, covering four waves SARS-CoV-2 infections. Clinical diagnostic were collected using an adapted...
<ns3:p>Background Electronic informed consent can improve accuracy, workflow, and overall patient experience in clinical research but has not been used Malawi, owing to uncertainty about availability, utility, data security technical support. Objectives We aimed explore the utility of electronic (e-consent) an ongoing human infection study Blantyre, Malawi. Methods The approved paper forms were digitized using Open Data Kit (ODK). Following participant information giving by staff, healthy...
Abstract ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global participation has resulted a large, comprehensive from hundreds sites across dozens countries. Data are analysed regularly reported publicly to inform patient care public health response. This report, our 18th final is part series published over 3...
<ns3:p><ns3:bold>Background</ns3:bold>: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing socioeconomic constraints, leading predictions that the COVID-19 pandemic would progress rapidly. However, due limited capacity test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of true burden infection and death. We, therefore, conducted...
Background The prevalence of diseases other than TB detected during chest X-ray (CXR) screening is unknown in sub-Saharan Africa. This represents a missed opportunity for identification and treatment potentially significant disease. Our aim was to describe quantify non-TB abnormalities identified by TB-focused CXR the 2016 Kenya National Prevalence Survey. Methods We reviewed random sample 1140 adult (≥15 years) CXRs classified as ‘abnormal, suggestive TB’ or ‘abnormal other’ field...
Ventilator-associated pneumonia commonly occurs in critically ill patients. Clinical suspicion results overuse of antibiotics, which turn promotes antimicrobial resistance. Detection volatile organic compounds the exhaled breath patients might allow earlier detection and avoid unnecessary antibiotic prescription. We report a proof concept study for non-invasive diagnosis ventilator-associated intensive care (the BRAVo study). Mechanically ventilated commenced on antibiotics clinical were...
Although the COVID-19 pandemic has left no country untouched there been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, healthy community controls (PCR-negative/IgG-negative). PCR-positive participants were more likely receive dexamethasone a beta-lactam antibiotic, survive hospital discharge than PCR-negative/IgG-positive...
Abstract Postacute COVID-19 patients are at risk of long-term functional impairment, and the rehabilitation community is calling for action preparing a “tsunami needs” in this patient population. In absence standard guidelines local evidence, 3-wk pulmonary telerehabilitation program was successfully delivered to postacute severe Malawi. The experienced persistent dyspnea fatigue, with remarkable impact on his health status. On final assessment, all respiratory severity scores had fallen by...