Jonathan Bannard‐Smith
A5052430845- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Emergency and Acute Care Studies
- COVID-19 Clinical Research Studies
- Advanced Chemical Sensor Technologies
- Intensive Care Unit Cognitive Disorders
- Renal Transplantation Outcomes and Treatments
- Health and Medical Research Impacts
- Mesenchymal stem cell research
- Long-Term Effects of COVID-19
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Pneumonia and Respiratory Infections
- Renal function and acid-base balance
- Organ Transplantation Techniques and Outcomes
- Patient Safety and Medication Errors
- Healthcare Operations and Scheduling Optimization
- Respiratory and Cough-Related Research
- Electrolyte and hormonal disorders
Manchester Royal Infirmary
2015-2025
University of Manchester
2015-2025
Manchester University NHS Foundation Trust
2019-2024
Manchester Academic Health Science Centre
2018-2020
Manchester University
2020
Newcastle University
2020
University of Edinburgh
2020
Austin Hospital
2016
Ysbyty Gwynedd Hospital NHS Trust
2015
Philips (United Kingdom)
2015
<h3>Importance</h3> In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low volume ventilation, may improve outcomes. <h3>Objective</h3> To determine whether lower using extracorporeal carbon dioxide removal improves outcomes failure. <h3>Design, Setting, and Participants</h3> This multicenter, randomized, allocation-concealed, open-label, pragmatic clinical trial enrolled 412 adult receiving...
BackgroundVentilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations IL-1β and IL-8 in bronchoalveolar lavage fluid have been validated as effective markers for exclusion ventilator-associated pneumonia. The VAPrapid2 trial aimed determine whether measurement could effectively safely improve antibiotic stewardship patients with clinically suspected...
Frailty is a state of vulnerability to poor resolution homeostasis after stressor event and strongly associated with adverse outcomes. Therefore, the assessment frailty may be an essential part evaluation in any healthcare encounter that might result escalation care. The purpose study was assess frequency association clinical outcomes patients subject rapid response team (RRT) review. In this multi-national prospective observational cohort study, centres existing RRTs collected data over...
Abstract Background Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides possible solution, as characterised disruption the microbiome. However, studies evaluating diagnostic capabilities microbiome analysis are limited, lack alignment on biomarkers. Using bronchoalveolar lavage fluid (BALF) from ventilated adult patients suspected VAP, we aimed to...
Albumin is the most abundant and perhaps important protein in human blood. Research has identified many of albumin's possible roles modulating acid-base balance, modifying inflammation, maintaining vascular endothelial integrity, binding endogenous exogenous compounds. plays a key role homeostasis endothelium, offering protection from inflammation damage to glycocalyx. binds diverse range It transports, delivers clears drugs, plus it helps with uptake, storage disposal potentially harmful...
OBJECTIVES: In patients with acute hypoxemic respiratory failure (AHRF), the use of lower tidal volume ventilation facilitated by veno-venous extracorporeal C O 2 removal (vv-ECCO R) does not improve clinical outcomes. The primary objective this analysis was to evaluate for differences in indices systemic inflammation and ventilator-induced lung injury between treated vv-ECCO R standard care. Secondary objectives included an evaluation heterogeneity treatment effect. DESIGN: Substudy a...
Bone marrow-derived, allogeneic, multipotent adult progenitor cells demonstrated safety and efficacy in preclinical models of acute respiratory distress syndrome (ARDS). This phase 1/2 trial evaluated the tolerability intravenous patients with moderate-to-severe ARDS 12 UK USA centres. Cohorts 1 2 were open-label, evaluating three subjects receiving 300 or 900 million cells, respectively. Cohort 3 was a randomised, double-blind, placebo-controlled parallel infusing (n = 20) placebo 10)...
Ventilator-associated pneumonia commonly occurs in critically ill patients. Clinical suspicion results overuse of antibiotics, which turn promotes antimicrobial resistance. Detection volatile organic compounds the exhaled breath patients might allow earlier detection and avoid unnecessary antibiotic prescription. We report a proof concept study for non-invasive diagnosis ventilator-associated intensive care (the BRAVo study). Mechanically ventilated commenced on antibiotics clinical were...
Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in COVID-19-related Acute Respiratory Distress Syndrome (ARDS). Objectives: We investigated safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) COVID-related ARDS. Methods: This multicentre, randomised, double-blind, allocation concealed, placebo-controlled trial (NCT03042143) randomised patients with moderate-to-severe ARDS to receive (400million cells) or placebo...
Fluid bolus therapy (FBT) is common in critically ill patients. With the exception of use patients with traumatic brain injury, FBT human albumin solution (HAS) appears safe and perhaps superior severe sepsis.To determine physiological effects 4% v 20% HAS.A retrospective observational study 202 receiving HAS a tertiary intensive care unit between April 2012 March 2013.FBT was instituted or HAS, according to clinician preference.We compared biochemical haemodynamic data groups at baseline 1,...
Abstract Background Early and accurate recognition of respiratory pathogens is crucial to prevent increased risk mortality in critically ill patients. Microbial-derived volatile organic compounds (mVOCs) exhaled breath could be used as noninvasive biomarkers infection support clinical diagnosis. Methods In this study, we investigated the diagnostic potential vitro–confirmed mVOCs patients under mechanical ventilation from BreathDx study. Samples were analyzed by thermal desorption–gas...
BackgroundAssessing circadian rhythmicity from infrequently sampled data is challenging; however, these types of are often encountered when measuring transcripts in hospitalized patients.MethodsWe present ClinCirc. This method combines 2 existing mathematical methods (Lomb-Scargle periodogram and cosinor) sequentially designed to measure oscillations clinical data. The accuracy this was compared against 9 other using simulated frequently biological ClinCirc then evaluated 13 intensive care...
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target varies in clinical practice. We hypothesised the effects of a 33 °C when compared normothermia would differ based on average hypothermia and those patients achieving fastest have more favorable outcomes. Methods In this post-hoc analysis TTM-2 trial, after out hospital arrest were randomized targeted (33 °C), followed by controlled re-warming, or with early treatment...
Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling available in mechanically ventilated patients. We identified potential sources of bias as illustrated this figure.
Background: As with the many specialities within medicine, expanding field of medical education is becoming a more formal and professionalised arena.Aim: This article aims to assist junior doctors wishing pursue educational roles in their future careers.Methods:We offer twelve tips for these aspirations mind, exploring range potential roles, resources opportunities available.Results: Twelve practical suggestions on how can nurture portfolios evidence subsequent careers education.Conclusions:...