A5076772705- Radioactive element chemistry and processing
- Nuclear Materials and Properties
- Radioactive contamination and transfer
- Nuclear reactor physics and engineering
- Wound Healing and Treatments
- Cell Adhesion Molecules Research
- Nuclear materials and radiation effects
- Radiation Effects and Dosimetry
- Electrospun Nanofibers in Biomedical Applications
- Quantum and electron transport phenomena
- Cellular Mechanics and Interactions
- Nuclear Physics and Applications
- Semiconductor materials and devices
- Spectroscopy and Quantum Chemical Studies
- Nuclear and radioactivity studies
- Fusion materials and technologies
- Inorganic Fluorides and Related Compounds
- Luminescence Properties of Advanced Materials
- Radiation Detection and Scintillator Technologies
- Combustion and Detonation Processes
- Graphene research and applications
- Semiconductor Quantum Structures and Devices
- NF-κB Signaling Pathways
- Semiconductor materials and interfaces
- Rare-earth and actinide compounds
Pacific Northwest National Laboratory
2012-2024
University of South Dakota
2024
Sanford Health
2024
Battelle
2013-2023
Government of the United States of America
2022-2023
NeoMatrix Therapeutics (United States)
2022
Richland College
2020
Stony Brook University
1993-2016
Waseda University
2013-2014
University of Missouri
2011-2013
<h3>Importance</h3> In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low volume ventilation, may improve outcomes. <h3>Objective</h3> To determine whether lower using extracorporeal carbon dioxide removal improves outcomes failure. <h3>Design, Setting, and Participants</h3> This multicenter, randomized, allocation-concealed, open-label, pragmatic clinical trial enrolled 412 adult receiving...
Fibronectin has many potential roles in wound repair, including chemotactic factor activity for monocytes, fibroblasts, and endothelial cells; opsonin promoter microorganism tissue debris; substratum cell migration localization; a scaffold building extracellular matrix. Although fibronectin been reported to have intrinsic growth-promoting ability, coisolation of authentic growth factors with raises doubts about this observation. Whether the addition exogenous wounds can augment healing is...
Researchers evaluated radionuclide measurements of environmental samples taken from the Fukushima Daiichi nuclear facility and reported on Tokyo Electric Power Co. Website following 2011 tsunami-initiated catastrophe. This effort identified Units 1 3 as major source radioactive contamination to surface soil near facility. Radionuclide trends in soils suggested that: (1) chemical volatility driven by temperature reduction potential within vented reactors' primary containment vessels dictated...
Normal adult human dermal fibroblasts grown in a three-dimensional collagen lattice increase mRNA level of receptor integrin subunit α2 (Xu, J., and R.A.F. Clark. 1996. J. Cell Biol. 132:239– 249.) DNA binding activity nuclear transcription factor, NF-κB 1997. 136:473–483.). Here we present evidence that the induced translocation p50, one member family, degradation an inhibitor protein, IκB-α. The inhibition by SN50, peptide targeted at NF-κB, significantly reduced induction protein lattice....
Alveolar macrophages are believed to be central in orchestrating the fibrotic response interstitial lung disease (ILD). To test hypothesis that from patients with ILD were dedicated growth factor production and this was independent of other indices macrophage activation, we measured mRNA B chain PDGF TGF-beta, as well HLA-DR-alpha alveolar normal control subjects. When examined immediately after lavage, cells had increased PDGF(B) but similar TGF-beta when compared Discoordinate regulation...
A three-dimensional collagen lattice can provide skin fibroblasts with a cell culture environment that simulates normal dermis. Such matrix regulates interstitial collagenase (type I metalloproteinase [MMP-1], collagenase-1) and receptor alpha2 subunit mRNA expression in both unstimulated or platelet-derived growth factor-stimulated dermal (Xu, J., R.A.F. Clark. 1996. J. Cell Biol. 132:239-249). Here we report the gel signal protein kinase C (PKC)-zeta activation human fibroblasts. An vitro...
Abstract We have made observations of noble metal phase fission-product agglomerates and gaseous xenon within the fuel-cladding interaction (FCI) zone a high-burnup UO 2 fuel. The FCI is boundary between pellet outer surface inner wall oxidized Zr-liner/cladding fuel rod. These are well known to occur spent matrix, although radionuclides been reported by others, we reveal aspects their speciation morphology. That they as discrete particles in Zr liner, suggests occurrence hitherto unknown...
Clinical distinction between superficial and deep burns is problematic. The authors determined whether an infrared thermal imaging (IRTI) camera could predict burn depth. Burn depth was assessed by experienced surgeon, the were imaged with a portable, lightweight IRTI that measures heat emission from skin using long wavelengths (7.5-13 μm). Burns considered "deep" if they surgically excised confirmed to be of full thickness on microscopic evaluation or did not heal spontaneously within 21...
Platelet-derived growth factor (PDGF) stimulates fibroblasts to move over collagen and contract three-dimensional gels, processes important in wound repair fibrocontractive diseases. These depend on alpha 2 beta 1 integrin ligation of PDGF induces the expression this integrin. Several lines evidence presented here suggest that PKC-zeta plays a role gene expression. The induction was blocked by chemical inhibitors for protein tyrosine kinases (PTK), genistein, kinase C (PKC), chelerythrine,...
Understanding the structural evolution and reduction-oxidation behavior of nuclear fuel cladding during operation is essential for predicting performance after service in light water reactors. Using TEM/STEM imaging cross-sections fuel-cladding oxide interface region high burnup BWR fuel, fission recoil radiation was demonstrated to not only stabilize tetragonal phase ZrO2 at temperatures well below equilibrium temperature, but also cause grain growth proportional damage. The exclusively...
We report elemental and isotopic analysis for the noble metal fission product phase found in irradiated nuclear fuel. The was isolated from three commercial UO2 fuels by chemically dissolving fuel matrix, leaving as undissolved residue. Macro amounts of this residue were dissolved using a KOH + KNO3 fusion then separated into individual elements mass spectrometry. Though composition has been previously reported, work is most comprehensive chemical to date. both abundances five major...
The degradation of the internal structure plutonium (IV) oxalate during calcination was investigated with Transmission Electron Microscopy (TEM), electron diffraction, Energy-Loss Spectroscopy (EELS), and 4D Scanning TEM (STEM). lift-outs were prepared from samples that had been calcined at 300°C, 450°C, 650°C 950°C. resulting phase all temperatures identified as PuO 2 diffraction. grain size range obtained high-resolution TEM. In addition, STEM images analyzed to provide distributions....
Production of the important 99mTc medical isotope parent, molybdenum-99 (99Mo), via fissioning high- and low-enriched uranium (HEU/LEU) targets followed by target dissolution in acid solution-phase purification 99Mo is time-consuming, generates quantities corrosive radioactive waste, can result release an array radionuclides to atmosphere. An alternative method has been devised that potential alleviate many these issues. Herein, we demonstrate feasibility a rapid Mo/Tc gas-phase separation...