A5078183484- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Animal and Plant Science Education
- Tissue Engineering and Regenerative Medicine
- Molecular Sensors and Ion Detection
- Spinal Cord Injury Research
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Amino Acid Enzymes and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Amphibian and Reptile Biology
- Species Distribution and Climate Change
- Cardiac Arrest and Resuscitation
- Foreign Body Medical Cases
- Innovations in Medical Education
- Enhanced Recovery After Surgery
- Metabolism and Genetic Disorders
- Tracheal and airway disorders
- Photochromic and Fluorescence Chemistry
- Organ and Tissue Transplantation Research
- Synthesis of heterocyclic compounds
- Health and Medical Research Impacts
- Mathematical Biology Tumor Growth
- Carcinogens and Genotoxicity Assessment
- Mesenchymal stem cell research
University of Cambridge
2021
University College London
2014-2020
Nerve Centre
2019-2020
University College Hospital
2016-2018
London Centre for Nanotechnology
2014
Chelsea and Westminster Hospital
2009
University of Montana
1997-2002
The vesicular glutamate transport (VGLUT) system selectively mediates the uptake of L-glutamate into synaptic vesicles. Uptake is linked to an H+-ATPase that provides coupling among ATP hydrolysis, electrochemical proton gradient, and transport. Substituted quinoline-2,4-dicarboxylic acids (QDCs), prepared by condensation dimethyl ketoglutaconate (DKG) with substituted anilines subsequent were investigated as potential VGLUT inhibitors in A brief panel QDCs was previously reported (Carrigan...
Medical simulators offer an invaluable educational resource for medical trainees. However, owing to cost and portability restrictions, they have traditionally been limited simulation centres. With the advent of sophisticated mobile technology, become cheaper more accessible. Touch Surgery is one such freely downloadable application simulator (MAS) used by over million healthcare professionals worldwide. Nevertheless, date, it has never formally validated as adjunct in undergraduate...
Purpose: To establish a sustainable model for “Surgical Shadowing Scheme” (SSS) and assess how this affects undergraduate attitudes to surgical careers. Patients methods: Surgeons at university teaching hospitals associated with UCL Medical School Partners, United Kingdom, were approached their willingness participate in the scheme. students then invited apply scheme, where individually matched operating theater sessions surgeons specialty of choice. Feedback was subsequently obtained,...
Abstract: A photolabile trifluoromethyldiazoketone derivative of kainate (KA), (2′ S ,3′ ,4′ R )‐2′‐carboxy‐4′‐(2‐diazo‐1‐oxo‐3,3,3‐trifluoropropyl)‐3′‐pyrrolidinyl acetate (DZKA), was synthesized and evaluated as an irreversible inhibitor the high‐affinity KA site on rat forebrain synaptic plasma membranes (SPMs). In absence UV irradiation, DZKA preferentially blocked [ 3 H]KA binding with IC 50 0.63 µ M , a concentration that produced little or no inhibition at AMPA NMDA sites. At 100...
Following a critical incident on our labour ward, we investigated the forces required to remove different bougies from tracheal tubes and effect of lubrication ease removal. Two studies were conducted: firstly examining differences between six with standard tube, secondly four bougie. The varied amongst both (p < 0.0001) 0.0001). Removal was generally easier but when corrected for multiple comparisons this did not reach statistical significance.
The isopropenyl side chain of kainic acid (KA) has been replaced with a trifluoromethyldiazoketone group, resulting in derivative ("diazoKA") that gives efficient photo-induced crosslinking to the active site KA class glutamate receptor. incorporation this functional group is accomplished via simple, one step coupling carboxylic and 2,2,2-trifluorodiazoethane procedure should be generally applicable preparation other photoaffinity labels. Major advantages include excellent stability towards...