A5060432189- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Neuroscience and Neuropharmacology Research
- Asymmetric Synthesis and Catalysis
- Molecular Sensors and Ion Detection
- Microbial Natural Products and Biosynthesis
- Coordination Chemistry and Organometallics
- Carbohydrate Chemistry and Synthesis
- Chemical Reaction Mechanisms
- Inorganic and Organometallic Chemistry
- Chemical synthesis and alkaloids
- Marine Toxins and Detection Methods
- Amino Acid Enzymes and Metabolism
- Oxidative Organic Chemistry Reactions
- Receptor Mechanisms and Signaling
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- RNA and protein synthesis mechanisms
- Organic Chemistry Cycloaddition Reactions
- Ion channel regulation and function
- Traditional and Medicinal Uses of Annonaceae
- Cyclopropane Reaction Mechanisms
- Advanced Synthetic Organic Chemistry
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
University of California, Irvine
2007-2023
University of California, Berkeley
2019-2020
Irvine University
1992-2008
University of California, Irvine Medical Center
2006
Scripps Institution of Oceanography
2005
Xenobe Research Institute
2005
University of California, San Diego
1976-2005
Exelixis (United States)
2003
University of Konstanz
2001
AgResearch
2001
The tumour suppressor p53 is the most frequently mutated gene in human cancer. Reactivation of mutant by small molecules an exciting potential cancer therapy. Although several compounds restore wild-type function to p53, their binding sites and mechanisms action are elusive. Here computational methods identify a transiently open pocket between loop L1 sheet S3 core domain. Mutation residue Cys124, located at centre pocket, abolishes reactivation R175H PRIMA-1, known compound. Ensemble-based...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomerRichard J. Bridges, Mark S. Stanley, Michael W. Anderson, Carl Cotman, and A. Richard ChamberlinCite this: Med. Chem. 1991, 34, 2, 717–725Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February...
Cyanobacteria (blue-green algae) (e.g., Microcystis and Nodularia spp.) capable of producing toxic peptides are found in fresh brackish water worldwide. These toxins include the microcystin (MC) heptapeptides (>60 congeners) nodularin pentapeptides (ca. 5 congeners). Cyanobacterial cyclic peptide harmful to man, other mammals, birds, fish. Acute exposure high concentrations these causes liver damage, while subchronic or chronic may promote tumor formation. The detection cyanobacterial...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthetic site-specific incorporation of a non-natural amino acid into polypeptideJ. D. Bain, Edward S. Diala, Charles G. Glabe, Thomas A. Dix, and Richard ChamberlinCite this: J. Am. Chem. Soc. 1989, 111, 20, 8013–8014Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ja00202a052https://doi.org/10.1021/ja00202a052research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyllithium reagents from arenesulfonylhydrazonesA. Richard Chamberlin, Jeffrey E. Stemke, and F. Thomas BondCite this: J. Org. Chem. 1978, 43, 1, 147–154Publication Date (Print):January 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/jo00395a033https://doi.org/10.1021/jo00395a033research-articleACS PublicationsRequest reuse permissionsArticle Views1872Altmetric-Citations158LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling chemical reactivity. 7. The effect of a change in rate-limiting step on the stereoselectivity electrophilic addition to allylic alcohols and related chiral alkenesA. Richard Chamberlin, Robert L. Mulholland Jr., Scott D. Kahn, Warren J. HehreCite this: Am. Chem. Soc. 1987, 109, 3, 672–677Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February...
Human cytochrome P450 3A4 (CYP3A4) is a key xenobiotic-metabolizing enzyme that oxidizes and clears the majority of drugs. CYP3A4 inhibition may lead to drug-drug interactions, toxicity, other adverse effects but, in some cases, could be beneficial enhance therapeutic efficiency coadministered pharmaceuticals are metabolized by CYP3A4. On basis our investigations analogs ritonavir, potent inactivator pharmacoenhancer, we have built pharmacophore model for CYP3A4-specific inhibitor. This...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling chemical reactivity. 4. Regiochemistry and stereochemistry of electrophilic additions to allylic double bondsS. D. Kahn, C. F. Pau, A. R. Chamberlin, W. J. HehreCite this: Am. Chem. Soc. 1987, 109, 3, 650–663Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://doi.org/10.1021/ja00237a003RIGHTS & PERMISSIONSArticle Views546Altmetric-Citations107LEARN ABOUT THESE...
Neuropeptide S (NPS) has been shown to modulate arousal, sleep wakefulness, anxiety-like behavior, and feeding after central administration of the peptide agonist mice or rats. We report here chemical synthesis pharmacological characterization SHA 66 (3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-<i>a</i>]pyrazine-7-carboxylic acid benzylamide) 68 4-fluoro-benzylamide), two closely related bicyclic piperazines with antagonistic properties at NPS receptor (NPSR). The compounds block NPS-induced...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIodocyclization of allylic alcohol derivatives containing internal nucleophiles. Control stereoselectivity by substituents in the acyclic precursorsA. Richard Chamberlin, Milana Dezube, Patrick Dussault, and Mark C. McMillsCite this: J. Am. Chem. Soc. 1983, 105, 18, 5819–5825Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of maytansineE. J. Corey, Leland O. Weigel, A. Richard Chamberlin, Hidetsura Cho, and Duy H. HuaCite this: Am. Chem. Soc. 1980, 102, 21, 6613–6615Publication Date (Print):October 8, 1980Publication History Published online1 May 2002Published inissue 8 October 1980https://pubs.acs.org/doi/10.1021/ja00541a064https://doi.org/10.1021/ja00541a064research-articleACS PublicationsRequest reuse permissionsArticle...
Quantification of black carbon (BC), carbonaceous material pyrogenic origin, has typically required either chemical or thermal oxidation methods for isolation from heterogeneous matrices, such as sediment soil. The benzene polycarboxylic acid (BPCA) method involves aromatic structures, those in BC, into BPCAs. We revised the BPCA with intent to quantify BC marine dissolved organic (DOC). As part this work, we evaluated mechanism and yield using nine polycyclic hydrocarbons (PAHs) six...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of optically active pyrrolizidinediols: (+)-heliotridineA. Richard Chamberlin and John Y. L. ChungCite this: J. Am. Chem. Soc. 1983, 105, 11, 3653–3656Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://doi.org/10.1021/ja00349a051RIGHTS & PERMISSIONSArticle Views948Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (-)-N-methylmaysenineE. J. Corey, Leland O. Weigel, A. Richard Chamberlin, and Bruce LipshutzCite this: Am. Chem. Soc. 1980, 102, 4, 1439–1441Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/ja00524a046https://doi.org/10.1021/ja00524a046research-articleACS PublicationsRequest reuse permissionsArticle...
RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, often contributes to drug-resistance. Abnormally elevated function hyperactive homologous recombination (HR) rates have been found in panel of cancers, including breast chronic myeloid leukaemia (CML). Directly targeting attenuating the deregulated has therefore proposed as an alternative supplementary strategy treatment. Here we show that newly identified small molecule, IBR2, disrupts...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective preparation of .beta.-alkyl-.gamma.-butyrolactones from functionalized ketene dithioacetalsStacie S. Canan Koch and A. Richard ChamberlinCite this: J. Org. Chem. 1993, 58, 10, 2725–2737Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 1993https://pubs.acs.org/doi/10.1021/jo00062a013https://doi.org/10.1021/jo00062a013research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantiomerically pure polyhydroxylated acyliminium ions. Synthesis of the glycosidase inhibitors (-)-swainsonine and (+)-castanospermineScott A. Miller Richard ChamberlinCite this: J. Am. Chem. Soc. 1990, 112, 22, 8100–8112Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ja00178a038https://doi.org/10.1021/ja00178a038research-articleACS...
Fluorescence spectroscopy is a powerful biophysical technique for studying protein structure, function, dynamics, and intermolecular interactions. Such studies are often conducted using intrinsic probes, such as tryptophan residues, or extrinsic probes introduced by post-translational modification, dansyl. Specificity, however, concern since many proteins contain more than one chemical modification will occur at site. Herein we report the in vitro, site-specific incorporation of three...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semi-synthetic aminoacyl-tRNAsJ. D. Bain, Edward S. Diala, Charles G. Glabe, Dean A. Wacker, Matthew H. Lyttle, Thomas Dix, and Richard ChamberlinCite this: Biochemistry 1991, 30, 22, 5411–5421Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June...
Reversible protein phosphorylation, which is mediated by kinases and phosphatases, a major control element of the cell. There diverse group toxic natural products that inhibit certain thereby disrupting normal biochemical pathways. These toxins can be useful for dissecting individual pathways associated with each these enzymes. This Article describes first total synthesis one such toxin, cyclic heptapeptide microcystin-LA. The features convergent route amenable to analog preparation in...