A5088486505- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- IgG4-Related and Inflammatory Diseases
- HIV/AIDS drug development and treatment
- Health Sciences Research and Education
- Health and Medical Research Impacts
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Cholinesterase and Neurodegenerative Diseases
- Advances in Oncology and Radiotherapy
University of Cambridge
2017-2024
Ziauddin University
2016-2024
Ziauddin Hospital
2020-2024
The Gurdon Institute
2018-2020
Creative Research Enterprises (United States)
2017
Karachi Institute of Heart Diseases
2017
Addenbrooke's Hospital
2017
Dow University of Health Sciences
2010
Grammar School
2010
Abstract Background & Aims Chronic hepatitis D (delta) is a major global health burden. Clinical and virological characteristics of patients with virus ( HDV ) infection treatment approaches in different regions world‐wide are poorly defined. Methods The Hepatitis Delta International Network HDIN registry was established 2011 centres Europe, Asia, North‐ South America. Here, we report on clinical/ the first 1576 ongoing or past included database until October 2016 performed retrospective...
Abstract Background and Aims Chronic hepatitis delta represents a major global health burden. Clinical features of D virus (HDV) infection vary largely between different regions worldwide. Treatment approaches are dependent on the approval status distinct drugs financial resources. Methods The Hepatitis Delta International Network (HDIN) registry involves researchers from all continents (Wranke, Liver 2018). We here report long‐term follow‐up data 648 patients recruited by 14 centres in 11...
To investigate the efficacy of pegylated interferon alfa (PEG-IFNα) therapy with and without entecavir in patients chronic hepatitis D.Forty D virus (HDV) RNA positive were randomized to receive either PEG-IFNα-2a 180 μg weekly combination 0.5 mg daily (n = 21) or PEG-IFNα alone =19). Patients who failed show 2 log reduction HDV level at 24 wk treatment, had detectable 48 considered as treatment failure. Treatment was continued for 72 rest patients. All followed post treatment. Intention...
Background/Aims: Sodium taurocholate co-transporting polypeptide (NTCP) is the receptor for hepatitis B virus (HBV) and D (HDV) entry into hepatocytes.Ezetimibe a cholesterol-lowering drug that possesses pharmacophore features to inhibit NTCP.This study evaluates efficacy of ezetimibe in patients with chronic HDV infection nonrandomized trial.Materials Methods: This proof concept phase 2 trial evaluated safety 10 mg daily (interferon treatment-experienced or interferon ineligible)...
Background Current literature on the prevalence and characteristics of hepatitis D virus (HDV) infection in young adults is limited. This study aims to determine disease severity adults. Methods The case records HDV RNA positive patients age 18-25 years were analyzed. Results Out 119 patients, 105 (88%) male. HBV-DNA was detectable 83 (70%). Hepatitis B e-antigen (HBeAg) non-reactive 99 (83%). Cirrhosis identified 45 (37.8%) individuals; nine (7.5%) classified as Child class or C....
Background Specific single nucleotide polymorphisms (SNPs) near the interferon lambda-3 (IFNλ3) gene (formerly interleukin 28B) influence response to treatment with in hepatitis C patients. We aimed investigate such an D Methods The study population consisted of patients who were previously treated pegylated for one year and spontaneous clearers virus post recent superinfection. SNP IFNλ3, rs12979860, was determined by polymerase chain reaction-restriction fragment length polymorphism...
AIMTo determine the predictive performance of cholinesterase compared to existing prognostic models in evaluating liver function patients with chronic hepatitis D. METHODSIn an observational, cross-sectional and retrospective study, consecutive D cirrhosis were evaluated.Demographic, clinical laboratory parameters recorded.Serum levels correlated scoring for disease Liver tests.Receiver operating characteristic (ROC) curves constructed find optimal level predicting ascites, Child Turcotte...
Background: Documentation of the effectiveness sofosbuvir and ribavirin with or without pegylated interferon alfa for hepatitis C virus Genotype 3 (HCV GT3) is limited in a real world setting. Objectives: The present study aimed at examining outcome above therapy Methods: Dual was given 24 weeks triple additional 12 weeks. Patients received dual when there unwillingness to take ineligibility. Results: In this analysis, 241 patients were included, whom 175 treated 66 therapy. mean age 46.6...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Background The autoimmune illnesses that affect the liver include hepatitis (AIH), primary biliary cholangitis (PBC), sclerosing (PSC), and overlap syndrome. In our patients, we aimed to address complete spectrum of disorders, clinical presentation, autoantibodies. Methods study included all patients diagnosed with disorder irrespective age, gender, ethnic background presented at clinic hospital in last two years. diagnosis was based on characteristic laboratory findings, presence one or...