A5078364436- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- HIV/AIDS oral health manifestations
- Viral Infections and Outbreaks Research
Centro de Pesquisas Oncológicas
2024
Brazilian Society of Tropical Medicine
2024
Universidade Federal de Rondônia
2016-2017
Faculdade de Medicina do ABC
2016
Companhia Energética de Minas Gerais (Brazil)
2013-2014
Fundação Oswaldo Cruz
2013
Abstract Background & Aims Chronic hepatitis D (delta) is a major global health burden. Clinical and virological characteristics of patients with virus ( HDV ) infection treatment approaches in different regions world‐wide are poorly defined. Methods The Hepatitis Delta International Network HDIN registry was established 2011 centres Europe, Asia, North‐ South America. Here, we report on clinical/ the first 1576 ongoing or past included database until October 2016 performed retrospective...
The hepatitis delta virus (HDV) is a pathogen that causes severe and rapidly progressive disease of hepatocytes. measurement viral load in the peripheral blood patients with HDV infections important for diagnosis, treatment monitoring, support follow-up studies replication during course disease. This study reports development an assay capable detecting quantifying abundance particles serum samples, based on reverse-transcription quantitative PCR (RT-qPCR). Two standards calibration were...
Abstract Hepatitis Delta is a disease caused by exposure to hepatitis B (HBV) and D (HDV) viruses, usually with more severe clinical outcome when compared an HBV monoinfection. To date, the real prevalence of HDV infection underestimated detection methods are poorly available, especially in endemic regions. Therefore, one-step RT-qPCR method for quantification HDV-RNA was developed. Biological samples were selected between 2017 2023 from patients at Ambulatório Especializado em Hepatites...
Currently there is a significant risk of infection with hepatitis B virus (HBV) during blood transfusion in high epidemic area. This due to the pre-seroconversion window period, immunovariant viral strains and presence occult HBV (OBI). The aim this study was develop an in-house real-time PCR-based method, which both ultra-sensitive efficient offering alternative method for nucleic acid testing (NAT). A precore fragment 109 bp cloned serial diluted standard curve construction. calibration -...
Hepatitis D virus (HDV) is endemic in the Amazon Region and its pathophysiology most severe among viral hepatitis. Treatment performed with pegylated interferon immune response appears to be important for infection control. HDV patients were studied: untreated polymerase chain reaction (PCR) positive (n = 9), anti-HDV PCR negative 8), responders treatment 12). The cytokines, interleukin (IL)-2 (p 0.0008) IL-12 0.02) differentially expressed groups also correlated 0.0143). Future studies will...
The emergence of clinically relevant mutations in the hepatitis B virus (HBV) genome has been a matter great debate because possibility escape from host’s immune system, potential to cause more severe progression liver diseases and treatment-resistant variants. Here we characterized circulating variants HBV Rondônia State, north Brazil. Serum samples 62 chronic carriers were subjected PCR assays clinical data collected. Mutations genotypes through direct sequencing. findings show presence...
Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) Interleukin 6 (IL-6) polymorphisms in development Chronic Liver Disease (CLD) patients infected with hepatitis Delta virus (HDV) Western Brazilian Amazon. Methods: Cross-sectional study conducted a cohort 40 chronic HDV patients, 27 CLD 13 without evident liver damage. Biological samples from participants were analyzed using polymerase chain reaction...
Hepatitis Delta represents a greater risk in the progression of advanced liver disease and HCC compared with HBV. The exact mechanism that determines spontaneous clearance delta virus or its to cirrhosis remains unknown. Therefore, this study aimed analyze clinical profile HBV HBV/HDV individuals Western Amazon.
Background: There are approximately 15 million individuals co-infected with HBV and HDV spread across several countries in the world, however this number is underestimated. superinfection more frequently associated liver failure, cirrhosis even development of hepatocellular carcinoma (HCC) when compared to HBV. Objective: This report presents cases three young patients possible who showed rapid disease severe form infection. Methods: Samples were collected at Ambulatório especializado em...
Abstract Hepatitis Delta is a disease caused by exposure to hepatitis B (HBV) and D (HDV) viruses, usually with more severe clinical outcome when compared an HBV monoinfection. To date, the real prevalence of HDV infection underestimated detection methods are poorly available, especially in endemic regions. Therefore, one-step RT-qPCR method for quantification HDV-RNA was developed. Biological samples were selected between 2017–2023 from patients at Ambulatório Especializado em Hepatites...
Abstract Background Hepatitis Delta represents an even greater risk in the progression of advanced liver disease compared with HBV and is related to rapid cirrhosis HCC. The exact mechanism that determines spontaneous clearance delta virus or its fibrosis remains unknown. In this scenario, studies on influence virological, immunological genetic aspects clinical evolution chronic carriers HDV are still scarce, especially Amazon region. Therefore, study aimed analyze profile infected...
Background: Chronic infection with the Hepatitis Delta Virus (HDV) is often associated severe liver decompensation and fulminant hepatitis, but in some cases, it can present a stable clinical presentation. Objectives: This study evaluated evolution of HDV-3 carriers from an endemic region western Brazilian Amazon. Methods: Cross-sectional was carried out Anti-HDAg reagent patients, seen at outpatient clinic specialized viral hepatitis located Rondônia, Brazil. Findings: A total 19 68.4% male...