A5082461149- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Virus-based gene therapy research
- Viral Infections and Outbreaks Research
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Biosensors and Analytical Detection
- Extracellular vesicles in disease
- COVID-19 diagnosis using AI
University of Oxford
2024-2025
University of Liverpool
2020-2024
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2020-2024
Kamuzu University of Health Sciences
2023
In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing socioeconomic constraints, leading predictions that the COVID-19 pandemic would progress rapidly. However, due limited capacity test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of true burden infection and death. We, therefore, conducted SARS-CoV-2 serosurvey amongst care...
The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance been critical for control, however not all countries can currently sustain community pathogen programs. Wastewater proven valuable in high-income settings, but less is known about the utility of water pathogens low-income countries. Here we show how wastewater SAR-CoV-2 be used to identify temporal changes help determine circulating variants quickly. In Malawi, a country with limited community-based...
<ns4:p><ns4:bold>Background</ns4:bold>: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing socioeconomic constraints, leading predictions that the COVID-19 pandemic would progress rapidly. However, due limited capacity test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of true burden infection and death. We, therefore, conducted...
Abstract Background Binding and neutralising anti-Spike antibodies play a key role in immune defence against SARS-CoV-2 infection. Since it is known that wane with time new immune-evasive variants are emerging, we aimed to assess the dynamics of an African adult population prior infection determine effect subsequent COVID-19 vaccination. Methods Using prospective cohort design, recruited adults laboratory-confirmed mild/moderate Blantyre, Malawi, followed them up for 270 days ( n = 52). A...
Macrophages, monocytes and neutrophils are major types of myeloid cells involved in inflammatory diseases, such as rheumatoid arthritis (RA). Recent scRNA-seq studies identified a remarkable diversity synovial macrophages but, with the exception lining macrophages, their geographical location specific roles remain largely unexplored. Here, we localised RELMa-positive predicted to produce high levels monocyte-recruiting chemokines, interstitium more specifically, vicinity interstitial blood...
<ns3:p><ns3:bold>Background</ns3:bold>: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing socioeconomic constraints, leading predictions that the COVID-19 pandemic would progress rapidly. However, due limited capacity test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, there are no reliable estimates of true burden infection and death. We, therefore, conducted...
Abstract The COVID-19 pandemic continues to impact health systems globally and robust surveillance is critical for control, however not all countries can sustain community programs. Wastewater has proven valuable in high-income settings, but little known about how river informal sewage low-income be used environmental of SARS-CoV-2. In Malawi, a country with limited community-based testing capacity, we explored the utility rivers wastewater SARS-CoV-2 surveillance. From May 2020 – January...
The SARS-CoV-2 Omicron variant has resulted in a high number of cases, but relatively low incidence severe disease and deaths, compared to the pre-Omicron variants. Therefore, we assessed differences symptom prevalence between infections sub-Saharan African population. We collected data from outpatients presenting at two primary healthcare facilities Blantyre, Malawi, November 2020 March 2022. Eligible participants were aged >1month old, with signs suggestive COVID-19, those not suspected...
ABSTRACT Background It is widely reported that the SARS-CoV-2 Omicron variant has resulted in high number of cases, but relatively low incidence severe disease and deaths, compared to pre-Omicron variants concern. We aim assess differences symptom prevalence between infections a sub-Saharan African population. Methods In this cross-sectional observational study, we collected data from children adult outpatients presenting at two primary healthcare facilities Blantyre, Malawi. Eligible...
<title>Abstract</title> <bold>Background.</bold> Hybrid immunity provides better protection against COVID-19 than vaccination or prior natural infection alone. It induces high magnitude and broadly cross-reactive neutralising anti-Spike IgG antibodies. However, it is not clear how long these potent antibodies last, especially in the context of adenovirus-based vaccines. <bold>Methods.</bold> We conducted a longitudinal cohort study enrolled 20 adults who had received an vaccine before...
Abstract Background Hybrid immunity provides better protection against COVID-19 than vaccination or prior natural infection alone. It induces high magnitude and broadly cross-reactive neutralising anti-Spike IgG antibodies. However, it is not clear how long these potent antibodies last, especially in the context of adenovirus-based vaccines. Methods We conducted a longitudinal cohort study enrolled 20 adults who had received an vaccine before laboratory-confirmed SARS-CoV-2 infection....