A5009024608- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Dermatology and Skin Diseases
- Nutrition, Genetics, and Disease
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Bioinformatics and Genomic Networks
- Air Quality and Health Impacts
- Food Allergy and Anaphylaxis Research
- Race, Genetics, and Society
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Genomics and Rare Diseases
- Climate Change and Health Impacts
- Nutritional Studies and Diet
- Gene expression and cancer classification
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Birth, Development, and Health
- COVID-19 epidemiological studies
- Health, Environment, Cognitive Aging
- BRCA gene mutations in cancer
- Respiratory and Cough-Related Research
- Child and Adolescent Health
- COVID-19 and healthcare impacts
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2016-2025
University of Cincinnati Medical Center
2014-2025
National Institute of Allergy and Infectious Diseases
2023
McMaster University
2022
Morehouse School of Medicine
2021
University of St. Augustine for Health Sciences
2021
Washington University in St. Louis
2021
Liberty University
2021
University of Lynchburg
2021
Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can implemented the clinic, including reduced performance of diverse populations, and interpretation communication genetic results both providers patients. To address these challenges, National Human Genome Research Institute-funded Electronic Medical Records Genomics (eMERGE) Network has developed a framework pipeline for return PRS-based genome-informed assessment...
Since COVID-19 became a pandemic, projection models were developed for Africa, with the assumption that SARS-CoV-2 has an exponential pattern of transmission.Crowded social life and poor personal hygiene in Africa can be conducive spread.However, as July 20, 2020, only about 9691 deaths have been reported from African continent among population 1.34 billion (compared to 143 000/328.2 million US alone).Although number infected subjects increased considerably during mid-July 2020 reaching...
Abstract Background Gender-based violence (GBV) particularly against women is unfortunately common during armed conflicts. No rigorous and comprehensive empirical work has documented the extent of GBV its consequences that took place two years devastating conflict in Northern Ethiopia. This study aims to assess war-torn areas northern Methods We used a qualitative method augmented by quantitative enroll research participants. conducted in-depth interviews characterize lived experiences...
Several studies have identified genes that are differentially expressed in atopic dermatitis (AD) compared to normal skin. However, there is also considerable variation the list of (DEGs) reported by different groups and exact cause AD still not fully understood. Using a rank-based approach, we analyzed gene expression data from five microarray studies, comprising total 127 samples more than 250,000 transcripts. A 89 signatures '89ADGES', including FLG gene, were show dysregulation...
Abstract Background and objective Ecological studies have suggested an association between exposure to particulate matter ≤2.5 μm (PM 2.5 ) coronavirus disease 2019 (COVID‐19) severity. However, these findings are yet be validated in individual‐level studies. We aimed determine the of long‐term PM with hospitalization among individual patients infected severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods estimated 10‐year (2009–2018) at residential zip code COVID‐19 diagnosed University...
We characterized vulnerable populations located in areas at higher risk of COVID-19-related mortality and low critical healthcare capacity during the early stage epidemic United States. analyze data obtained from a Johns Hopkins University COVID-19 database to assess county-level spatial variation relation health determinants infrastructure. Overall, we identified highly populated polluted areas, regional air hub race minorities (non-white population), Hispanic or Latino population with an...
Introduction Atopic dermatitis (AD) is an allergic skin disease mediated by barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD; however, mechanism which AHR partially ameliorates AD not well known. Methods Gene expression data from human biopsies were analyzed, compared to gene RNA-sequencing our in-vitro HaCaT cell model system. Western blot, ELISA qRT-PCR used further explore relationship...
Abstract Disparities across racial and ethnic groups are present for a range of health outcomes. In this opinion piece, we consider the origin groupings, history that highlights sociopolitical nature these terms. Indeed, terms race ethnicity exist purely as social constructs must not be used interchangeably with genetic ancestry. There is no scientific evidence traditionally call “races/ethnicities” have distinct, unifying biological or basis. Such focus runs risk compounding equity gaps...
Abstract Background The standard approach to determine unique or shared genetic factors across populations is identify risk alleles in one population and investigate replication others. However, since differ DNA sequence information, allele frequencies, effect sizes, linkage disequilibrium patterns, SNP association using a uniform stringent threshold on p values may not be reproducible populations. Here, we developed rank-based methods population-specific loci pathways for childhood asthma...