A5026331946- HIV Research and Treatment
- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Delphi Technique in Research
- COVID-19 Impact on Reproduction
- HIV-related health complications and treatments
- Global Maternal and Child Health
- HIV/AIDS drug development and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Respiratory Support and Mechanisms
- Adolescent Sexual and Reproductive Health
- Gut microbiota and health
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Emergency and Acute Care Studies
- Epigenetics and DNA Methylation
- vaccines and immunoinformatics approaches
- Global Public Health Policies and Epidemiology
- Alcohol Consumption and Health Effects
- Healthcare Systems and Reforms
Makerere University
2016-2025
Rutgers, The State University of New Jersey
2023
Johns Hopkins University
2020-2021
Lung Institute
2020-2021
University of Exeter
2020
University of Vermont Medical Center
2018
Unmet need for family planning exceeds 33% in Uganda. One approach to decreasing unmet is promoting male involvement planning. Male disapproval of use by their female partners and misconceptions about side effects are barriers globally Uganda particular. Researchers have conducted a number qualitative studies recent years examine different aspects among Ugandan men. The present study aimed quantify men's knowledge rural understand how better involve men couples' contraceptive...
Detailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited.We determined clinical treatment diagnosed Uganda.As 16 May 2020, a total 203 cases had been confirmed. We report first 56 patients; 29 received hydroxychloroquine (HCQ) 27 did not. Endpoints included admission to intensive care, mechanical ventilation or death during hospitalisation.The median age was 34.2 years; 67.9% were male; 14.6% <18 years. Up 57.1% asymptomatic. The most...
Convalescent plasma (CCP) has been studied as a potential therapy for COVID-19, but data on its efficacy in Africa are limited.In this trial we set out to determine the of CCP treatment COVID-19 Uganda.Patients with positive SARS-CoV-2 reverse transcriptase (RT)-PCR test irrespective disease severity were hospitalised and randomised receive either plus standard care (SOC) or SOC alone. The primary outcome was time viral clearance, defined having two consecutive RT-PCR-negative tests by day...
With an ageing HIV-positive population, sub-Saharan Africa is now facing a dual epidemic of communicable and non-communicable diseases (NCDs). This study aimed to assess trends in the prevalence hypertension factors associated with hypertension, among adults attending ambulatory HIV clinic Kampala, Uganda.We conducted retrospective chart review identify patients hypertension. We used random number generator select 400 patient charts from each year 2009 2014. Blood pressure, age, body mass...
In Sub-Saharan Africa, COPD remains prevalent but its association with HIV is not well characterized especially in rural settings. We assessed for prevalence, associated factors and lung function profile among HIV-infected individuals attending ART clinics Nakaseke district of Uganda. enrolled HIV-positive participants from four treatment centers Participants underwent spirometry testing following standard guidelines. defined as a post-bronchodilator FEV1/FVC ratio less than the fifth...
Even with ART available, HIV-infected individuals are at high risk of suffering comorbidities, as shown by the prevalence noninfectious lung diseases in HIV population. Recent studies have suggested a role for respiratory microbiota driving chronic inflammation.
Background: We examined the effect of physical position on peak inspiratory flow (PIF) in patients with chronic obstructive pulmonary disease (COPD) using dry powder inhalers (DPIs) low-medium (R2) and/or high (R5) internal resistance.Methods: This prospective study stable, ambulatory spirometry-confirmed COPD evaluated three positions maximal PIF achieved.Participants had 30-90 L/min or 60-90 (R2 DPIs) In-Check™ DIAL.PIF was measured triplicate randomly that might be while their inhaler...
Abstract Background Non-communicable diseases (NCDs) are an increasing global concern, with morbidity and mortality largely occurring in low- middle-income settings. We established the prospective Rural Uganda Non-Communicable Disease (RUNCD) cohort to longitudinally characterize NCD prevalence, progression, complications rural Africa. Methods conducted a population-based census for research. systematically enrolled adults each household among three sub-counties of larger Nakaseke Health...
remains one of the deadliest infectious agents globally. Amidst efforts to control TB, long treatment duration, drug toxicity, and resistance underscore need for novel therapeutic strategies. Despite advances in understanding interplay between microbiome disease humans, specific role predicting susceptibility discriminating infection status tuberculosis still needs be fully investigated. We investigated impact
Respiratory diseases remain a significant cause of global morbidity and mortality primary care plays central role in their prevention, diagnosis management. An e-Delphi process was employed to identify prioritise the current respiratory research needs health professionals worldwide. One hundred twelve community-based physicians, nurses other healthcare from 27 high-, middle- low-income countries suggested 608 initial questions, reduced after evidence review by academic experts 176 questions...
<strong>Introduction:</strong> The association between HIV status and hypertension is not well described within sub-Saharan Africa. We examined prevalence risk factors for among positive negative individuals living in a rural district of Uganda. <strong>Methods:</strong> conducted cross-sectional analysis two concurrent cohorts 600 721 seropositive aged ≥35 years. <strong>Results:</strong> Of the participants, 59.8% were women median age was 44.3 years, while individuals, 55% 47.8 Over 90%...
Throughout the world, there are antiretroviral therapy-naive HIV+ individuals who maintain elevated peripheral CD4 T-cell counts, historically referred to as long-term nonprogressors (LTNPs). With recent improvements in viral load (VL) detection methods levels low 20 copies per milliliter, 2 subsets of LTNPs have been defined: elite controllers (ECs), with undetectable VLs for at least 6-12 months, and viremic (VCs), between 200 2000 milliliter. ECs VCs extensively studied developed world...
Introduction Evidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment is increasingly emerging. However, very few African countries have undertaken collection and processing CCP. The aim this study was to assess feasibility collecting CCP, in preparation a randomized clinical trial CCP Uganda. Methods In cross-sectional study, persons with documented evidence recovery from Uganda were contacted screened blood donation via telephone calls. Those found eligible asked...
Abstract Background Several mechanisms including reduced CCR5 expression, protective HLA, viral restriction factors, broadly neutralizing antibodies, and more efficient T-cell responses, have been reported to account for HIV control among controllers. However, no one mechanism universally accounts all In this study we determined whether expression Ugandan We controllers compared with treated non-controllers through ex-vivo characterization of CD4 + T cells isolated from archived PBMCs...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with varied clinical and pathophysiological characteristics. Although there increasing evidence that COPD in low-income middle-income countries may have different characteristics from high-income countries, little known about phenotypes these settings. We describe the risk factor profile of population Uganda.
Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role immune response against HIV. TRIM5α targets HIV capsid for proteosomal destruction. Cyclophilin A, intracellular protein has also been reported to influence infectivity cell-specific manner. Accordingly, variations A genes have documented HIV-1 disease progression. However, these not among Elite controllers Uganda whether they play viral...
INTRODUCTION: Unintended pregnancy is a significant modifiable factor contributing to the high maternal mortality rate in Uganda. This study compares women and men’s knowledge of attitudes toward family planning (FP) rural Uganda understand potential barriers its use. METHODS: Data were collected from villagers through surveys Nakaseke District, (N=362). Participants’ socio-demographics, indicators unmet need, knowledge/accessibility FP services queried analyzed. RESULTS: 183 179 men...
Abstract Introduction Evidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment is increasingly emerging. However, very few African countries have undertaken collection and processing CCP. The aim this study was to assess feasibility collecting CCP, in preparation a randomized clinical trial CCP Uganda. Methods In cross-sectional study, persons with documented evidence recovery from Uganda were contacted screened blood donation via telephone calls. Those found...
Respiratory diseases impose a significant burden on global morbidity and mortality accounting for 7.7m deaths/yr. Primary care plays an essential role in the prevention, diagnosis management of respiratory diseases, relevant evidence-based guidelines are required. However, there is lack investment primary research up-to-date prioritised needs statement should help to bridge this gap. An e-Delphi exercise was conducted identify prioritise most important questions topics clinicians globally....