A5077961580- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- Ultrasound in Clinical Applications
- Global Public Health Policies and Epidemiology
- Asthma and respiratory diseases
- Tuberculosis Research and Epidemiology
- Inhalation and Respiratory Drug Delivery
- Climate Change and Health Impacts
- Public Health and Nutrition
- Health disparities and outcomes
- Air Quality and Health Impacts
- School Health and Nursing Education
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Global Maternal and Child Health
- HIV-related health complications and treatments
- Energy and Environment Impacts
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- HIV/AIDS Research and Interventions
- Chronic Disease Management Strategies
- Pediatric health and respiratory diseases
- Obstructive Sleep Apnea Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare Systems and Reforms
University of Miami
2021-2025
Johns Hopkins University
2015-2024
Johns Hopkins Medicine
2016-2023
University of Miami Health System
2023
Health First
2023
Pulmonary and Critical Care Associates
2016-2022
University College London
2020-2021
American Thoracic Society
2021
The Royal Free Hospital
2021
Universidad de San Martín de Porres
2020
Rationale: Forty percent of households worldwide burn biomass fuels for energy, which may be the most important contributor to household air pollution.Objectives: To examine association between pollution exposure and chronic obstructive pulmonary disease (COPD) outcomes in 13 resource-poor settings.Methods: We analyzed data from 12,396 adult participants living resource-poor, population-based settings. Household was defined as using materials primary fuel source home. used multivariable...
Background: Socioeconomic status (SES) is a strong social determinant of health. There remains limited understanding the association between SES and COPD prevalence among low- middle-income countries where majority COPD-related morbidity mortality occurs. We examined using data collected in Argentina, Bangladesh, Chile, Peru, Uruguay. Methods: compiled lung function, demographic, from three population-based studies for 11,042 participants aged 35–95 years. used multivariable alternating...
<h3>Importance</h3> Most of the global morbidity and mortality in chronic obstructive pulmonary disease (COPD) occurs low- middle-income countries (LMICs), with significant economic effects. <h3>Objective</h3> To assess discriminative accuracy 3 instruments using questionnaires peak expiratory flow (PEF) to screen for COPD LMIC settings. <h3>Design, Setting, Participants</h3> A cross-sectional analysis accuracy, conducted between January 2018 March 2020 semiurban Bhaktapur, Nepal; urban...
Chronic obstructive pulmonary disease (COPD) is a prevalent and burdensome condition in low- middle-income countries (LMICs). Challenges to better care include more effective diagnosis access affordable interventions. There are no previous reports describing therapeutic needs of populations with COPD LMICs who were identified through screening.
The prevalence of hypertension and diabetes are expected to increase in sub-Saharan Africa over the next decade. Some studies have documented that lifestyle factors lack awareness directly influencing control these diseases. Yet, few attempted understand barriers conditions rural settings. main objective this study was challenges care Uganda.We conducted semi-structured interviews with 24 patients and/or diabetes, 11 health professionals (HCPs), 12 community workers (known as village team...
Objective To determine the prevalence of chronic respiratory diseases in urban and rural Uganda to identify risk factors for these diseases.Methods The population-based, cross-sectional study included adults aged 35 years or older.All participants were evaluated by spirometry according standard guidelines completed questionnaires on symptoms, functional status demographic characteristics.The presence four conditions was monitored: obstructive pulmonary disease (COPD), asthma, bronchitis a...
Detailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited.We determined clinical treatment diagnosed Uganda.As 16 May 2020, a total 203 cases had been confirmed. We report first 56 patients; 29 received hydroxychloroquine (HCQ) 27 did not. Endpoints included admission to intensive care, mechanical ventilation or death during hospitalisation.The median age was 34.2 years; 67.9% were male; 14.6% <18 years. Up 57.1% asymptomatic. The most...
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Chronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority studies on CKD SSA have been conducted among HIV-infected populations mainly from large health facilities. We determined the prevalence its predictors communities central Uganda. A cross-sectional study was Wakiso district using multi-stage sampling. Data collected age, sex, socio-economic status, history alcohol intake, diabetes mellitus, hypertension smoking. Measurement blood...
The Global Alliance for Chronic Disease (GACD) is an alliance of health research funders whose teams form a network multidisciplinary health-care professionals and researchers. We aim to reduce the impact non-communicable diseases (NCDs) through focus on implementation in low-income middle-income countries (LMICs) vulnerable populations high-income (HICs). GACD has commissioned hypertension, diabetes, chronic respiratory diseases, mental health, 2018, scale up hypertension diabetes...
Convalescent plasma (CCP) has been studied as a potential therapy for COVID-19, but data on its efficacy in Africa are limited.In this trial we set out to determine the of CCP treatment COVID-19 Uganda.Patients with positive SARS-CoV-2 reverse transcriptase (RT)-PCR test irrespective disease severity were hospitalised and randomised receive either plus standard care (SOC) or SOC alone. The primary outcome was time viral clearance, defined having two consecutive RT-PCR-negative tests by day...
The relationship of body mass index (BMI) with lung function and COPD has been previously described in several high-income settings. However, few studies have examined this resource-limited settings where being underweight is more common. We evaluated the association between BMI outcomes across 14 diverse low- middle-income countries. included data from 12,396 participants aged 35–95 years used multivariable regressions to assess either while adjusting for known risk factors. An inflection...
The majority of non-communicable disease related deaths occur in low- and middle-income countries. Patient-centered care is an essential component chronic management high income settings.To examine feasibility implementation a validated patient-centered education tool among patients with heart failure Uganda.Mixed-methods, prospective cohort.A private public cardiology clinic Mulago National Referral Teaching Hospital, Kampala, Uganda.Adults primary diagnosis failure.PocketDoktor Educational...
More than 90% of the morbidity and mortality from chronic respiratory disease occurs in low-income middle-income countries (LMICs), with substantial economic impact. Preserved ratio impaired spirometry (PRISm) is a prevalent lung function abnormality associated increased high-income countries. We aimed to conduct post-hoc analysis cross-sectional study assess prevalence of, risk factors for, impact PRISm three diverse LMIC settings.
Introduction: Non-invasive assessments of lung volume distribution often require inhaled contrast and are limited by low regional resolution. We aimed to examine a non-contrast imaging method spatial displacement, adapted assess changes with non-invasive positive pressure ventilation (NIPPV) Methods: This study evaluated displacement in nine healthy volunteers (6 males, 3 females; ages 29 - 55 years; BMI 20.2 31.3 kg/m 2 ) using X-ray velocimetry (XV). Participants were assessed during tidal...
Spirometry, while necessary for the diagnosis of COPD, remains a scarce and costly resource worldwide. Screening questionnaires may help to bridge diagnostic gap. We evaluated performance St. George's Respiratory Questionnaire (SGRQ) as screening tool using spirometry-confirmed COPD gold standard. screened adults aged ≥40 years in Bhaktapur, Nepal; Lima, Peru; Nakaseke, Uganda. Participants completed SGRQs pre-bronchodilator peak expiratory flow (PEF). defined post-bronchodilator FEV1/FVC...