A5002596213- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiovascular and exercise physiology
- Chronic Disease Management Strategies
- Delphi Technique in Research
- Long-Term Effects of COVID-19
- Health and Wellbeing Research
- Nutrition and Health in Aging
- Physical Activity and Health
- Asthma and respiratory diseases
- Retinoids in leukemia and cellular processes
- Intensive Care Unit Cognitive Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 and Mental Health
- Cardiac Health and Mental Health
- Muscle metabolism and nutrition
- Pleural and Pulmonary Diseases
- Exercise and Physiological Responses
- American Environmental and Regional History
- Frailty in Older Adults
- Antioxidant Activity and Oxidative Stress
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Heart Rate Variability and Autonomic Control
- Nursing Diagnosis and Documentation
University Hospitals of Leicester NHS Trust
2016-2025
University of Leicester
2016-2025
NIHR Leicester Biomedical Research Centre
2015-2024
Imperial College London
2024
Swiss Federal Laboratories for Materials Science and Technology
2024
Glenfield Hospital
2014-2023
National Institute for Health Research
2017-2023
University of Liverpool
2022-2023
University of Manchester
2023
Manchester Academic Health Science Centre
2023
<h3>Importance</h3> Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness safety of these noninvasive strategies. <h3>Objective</h3> To determine whether either CPAP or HFNO, compared conventional therapy, improves clinical outcomes hospitalized COVID-19–related failure. <h3>Design, Setting, Participants</h3> A parallel group,...
Nutrition and metabolism have been the topic of extensive scientific research in chronic obstructive pulmonary disease (COPD) but clinical awareness impact dietary habits, nutritional status interventions may on COPD incidence, progression outcome is limited. A multidisciplinary Task Force was created by European Respiratory Society to deliver a summary evidence description current practice assessment therapy COPD, provide directions for future research. members conducted focused reviews...
Pulmonary rehabilitation is a highly effective treatment for people with chronic lung disease but remains underused across the world. Recent years have seen emergence of new program models that aim to improve access and uptake, including telerehabilitation low-cost, home-based models. This workshop was convened achieve consensus on essential components pulmonary identify requirements successful implementation emerging A Delphi process involving experts from world identified 13 must be...
<b>Objective</b> To investigate whether an early rehabilitation intervention initiated during acute admission for exacerbations of chronic respiratory disease reduces the risk readmission over 12 months and ameliorates negative effects episode on physical performance health status. <b>Design</b> Prospective, randomised controlled trial. <b>Setting</b> An cardiorespiratory unit in a teaching hospital medical affiliated district general hospital, United Kingdom. <b>Participants</b> 389...
Section:ChooseTop of pageAbstract <<Summary Recommendation...IntroductionMethodsResultsDiscussionConclusionsAuthors’ NoteReferences
Epidemiologic studies have found an inverse association between consumption of tomato products and the risk certain types cancers. However, mechanisms underlying this relationship are not completely understood. One mechanism that has been suggested is induction phase II detoxification enzymes. Expression enzymes regulated by antioxidant response element (ARE) transcription factor Nrf2 (nuclear E2-related 2). In study, we determined role system in carotenoids. We transiently transfected...
The measurement of body composition is value in the nutritional assessment patients with chronic obstructive pulmonary disease (COPD). purpose present study was to compare two bedside methods for using dual energy X‐ray absorptiometry (DEXA) as a reference method. Fat-free mass (FFM) measured DEXA, bioelectric impedance analysis (BIA) and skinfold anthropometry (SFA) cohort 85 COPD accepted rehabilitation. Patients whose index >30 were excluded. Relative BIA underestimated FFM, whereas it...
<b>Background:</b> Pulmonary rehabilitation is effective in improving exercise performance and health status chronic obstructive pulmonary disease (COPD). However, the role of nutritional support enhancement benefits training has not been explored. A double blind, randomised, controlled trial carbohydrate supplementation was undertaken patients attending outpatient rehabilitation. <b>Methods:</b> 85 with COPD were randomised to receive a 570 kcal rich supplement or non-nutritive placebo...
To characterise the sketetal muscle metabolic phenotype during early critical illness.Vastus lateralis biopsies and serum samples (days 1 7) were obtained from 63 intensive care patients (59% male, 54.7±18.0 years, Acute Physiology Chronic Health Evaluation II score 23.5±6.5).From day to 7, there was a reduction in mitochondrial beta-oxidation enzyme concentrations, biogenesis markers (PGC1α messenger mRNA expression (-27.4CN (95% CI -123.9 14.3); n=23; p=0.025) DNA copy number (-1859CN (IQR...
Studies of programmes self-management support for chronic obstructive pulmonary disease (COPD) have been inconclusive. The Self-Management Programme Activity, Coping and Education (SPACE) FOR COPD is a 6-week intervention COPD, this study aimed to evaluate the effectiveness in primary care. A single-blind randomised controlled trial recruited people with from care participants receive usual or SPACE COPD. Outcome measures were performed at baseline, 6 weeks months. outcome was symptom...
Rationale: Hospitalization represents a major event for the patient with chronic respiratory disease. There is high risk of readmission, which over longer term may be related more closely to underlying condition patient, such as skeletal muscle dysfunction.Objectives: We assessed hospital readmission at 1 year, including measures lower limb part larger clinical trial.Methods: Patients hospitalized an exacerbation disease underwent function quadriceps ultrasound. Independent factors...
Purpose: To explore how patients who refuse referral to Pulmonary Rehabilitation (PR) appraise acute exacerbations of Chronic Obstructive Disease (COPD), in the context having considered and declined PR. Method: Six participants recently hospitalized with an exacerbation COPD refused a PR subsequent hospital discharge participated in-depth interviews. Transcripts were subjected Interpretative Phenomenological Analysis (IPA). Results: Three conceptual themes emerged comprising: "Construction...
The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and associated "lockdown" measures on exacerbations chronic obstructive pulmonary disease (AECOPD) is unknown. We aimed to evaluate change in AECOPD treatment frequency during first 6 weeks lockdown UK compared with 2019 assess changes self-reported behaviour wellbeing.
Background Lung volume reduction surgery (LVRS) and bronchoscopic lung (BLVR) with endobronchial valves can improve outcomes in appropriately selected patients emphysema. However, no direct comparison data exist to inform clinical decision making people who appear suitable for both procedures. Our aim was investigate whether LVRS produces superior health when compared BLVR at 12 months. Methods This multicentre, single-blind, parallel-group trial randomised from five UK hospitals, were a...
Key to the success of human reproduction is capacity an embryo attach and implant into endometrial wall after which a nutrient supply established through placentation. Herein, we have examined potential epigenetic regulation uterine receptivity by use receptive RL95-2 nonreceptive AN3-CA epithelial carcinoma cell lines. Using in vitro model implantation, demonstrate that inhibition DNA methylation 5′-aza-2′-deoxycytidine (AZA), resulted line becoming BeWo spheroid attachment. Examination...
For the prevention of contrast-induced nephropathy (CIN) after coronary angiography, hydration by 0.9% sodium chloride solution and N-acetylcysteine is currently recommended. However, it unclear whether volume supplementation with bicarbonate better than when used in conjunction nonionic, low-osmolar iopamidol. The aim this study was to analyze compare effects on renal function 145 patients exposed nonionic iso-osmolar contrast medium iodixanol a randomized study.Renal Insufficiency...
Abstract Background Quantifying the improvements in lower limb or quadriceps muscle mass following resistance training (RT), is an important outcome measure COPD. Ultrasound a portable, radiation free imaging technique that can size of superficial muscles belonging to group such as rectus femoris, but has not been previously used COPD patients RT. We compared responsiveness ultrasound derived measures against dual energy x-ray absorptiometry (DEXA), with and healthy controls programme high...
Bimagrumab is a fully human monoclonal antibody that blocks the activin type II receptors, preventing activity of myostatin and other negative skeletal muscle regulators.
<h3>Background</h3> Pulmonary rehabilitation (PR) improves exercise capacity and health status in patients with COPD, but many assessed for PR do not complete therapy. It is unknown whether socioeconomic deprivation associates rates of completion or the magnitude clinical benefits bequeathed by PR. <h3>Methods</h3> services across England Wales enrolled to National audit 2015. Deprivation was using Index Multiple (IMD) derived from postcodes. Study outcomes were therapy change measures...