A5017018063- Pharmaceutical and Antibiotic Environmental Impacts
- Enzyme-mediated dye degradation
- Education, Psychology, and Social Research
- Sepsis Diagnosis and Treatment
- Analytical chemistry methods development
- Lipoproteins and Cardiovascular Health
- Respiratory Support and Mechanisms
- Analytical Chemistry and Chromatography
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Congenital Diaphragmatic Hernia Studies
- Water Treatment and Disinfection
- Cardiac Arrest and Resuscitation
- Dye analysis and toxicity
- Clinical Reasoning and Diagnostic Skills
- Healthcare Decision-Making and Restraints
- Advanced Biosensing Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Family and Patient Care in Intensive Care Units
- Animal testing and alternatives
- Microbial bioremediation and biosurfactants
- Environmental Toxicology and Ecotoxicology
- Cardiac, Anesthesia and Surgical Outcomes
- Pesticide Residue Analysis and Safety
The Recovery Center
2022
Czech Academy of Sciences, Institute of Microbiology
2016-2021
Charles University
2018-2021
Czech Academy of Sciences
2016-2021
NIHR Surgical Reconstruction and Microbiology Research Centre
2021
Heartlands Hospital
2007-2021
University College London
2020
University College London Hospitals NHS Foundation Trust
2020
Institute of Microbiology
2016
Heart of England NHS Foundation Trust
2008-2012
<h3>Importance</h3> Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness safety of these noninvasive strategies. <h3>Objective</h3> To determine whether either CPAP or HFNO, compared conventional therapy, improves clinical outcomes hospitalized COVID-19–related failure. <h3>Design, Setting, Participants</h3> A parallel group,...
Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim this study was to determine if acute administration atorvastatin reduces progression in statin naïve patients hospitalized with sepsis. A single centre phase II randomized double-blind placebo-controlled trial. Patients were 40 mg daily or placebo for duration their hospital stay up a maximum 28-days. primary end-point rate progressing severe during...
Chlorhexidine (CHX) and octenidine (OCT), antimicrobial compounds used in oral care products (toothpastes mouthwashes), were recently revealed to interfere with human sex hormone receptor pathways. Experiments employing model organisms-white-rot fungi Irpex lacteus Pleurotus ostreatus-were carried out order investigate the biodegradability of these endocrine-disrupting capability their extracellular enzyme apparatuses biodegrade CHX OCT. Up 70% ± 6% was eliminated comparison a heat-killed...
Summary A 65‐year‐old man underwent parathyroidectomy for hyperparathyroidism secondary to renal failure. Intra‐operatively he received methylene blue infusion (7.5 mg.kg −1 , a total of 650 mg in 500 ml 0.9% sodium chloride) visualisation parathyroid glands. At the end surgery, following extubation developed agitation, intense shivering and hyperpyrexia, his level consciousness decreased Glasgow Coma score 7. The differential diagnoses included toxicity or malignant hyperpyrexia. His lungs...
COVIDTrach is a UK multicentre prospective cohort study project that aims to evaluate the outcomes of tracheostomy in patients with COVID-19 receiving mechanical ventilation and record incidence SARS-CoV-2 infection among healthcare workers involved procedure.Data on patient demographic, clinical history were entered prospectively updated over time via an online database (REDCap). Clinical variables compared outcomes, logistic regression used develop model for mortality. Participants...