A5045097169- Pharmaceutical Practices and Patient Outcomes
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Treatments and Mutations
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Airway Management and Intubation Techniques
- Congenital Diaphragmatic Hernia Studies
- Multiple Myeloma Research and Treatments
- Health and Medical Research Impacts
- Tracheal and airway disorders
- Health Sciences Research and Education
- Medication Adherence and Compliance
- Bone health and treatments
- Chronic Myeloid Leukemia Treatments
- Pharmacy and Medical Practices
- Pain Management and Opioid Use
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Ethics in Clinical Research
- Innovations in Medical Education
- Problem and Project Based Learning
- Patient Safety and Medication Errors
Durham VA Medical Center
2020-2024
University of North Carolina at Chapel Hill
2014-2024
Durham VA Health Care System
2021-2024
William S. Middleton Memorial Veterans Hospital
2023
University of North Carolina Health Care
2015-2023
University College London Hospitals NHS Foundation Trust
2020
University College London
2020
UNC Lineberger Comprehensive Cancer Center
2019
Calvin University
2017
Indiana University School of Medicine
2016
The outcomes of a patient-centered layered learning practice model (LLPM) in which the clinical specialist acted as attending pharmacist and managed pharmacy team to provide direct patient care were evaluated.Two 30-day evaluations conducted on acute malignant hematology medical oncology services University North Carolina Medical Center 2011. primary objective this study was design an LLPM that used expand offered. outcome frequency encounters at discharge (medication reconciliation...
The polyamines spermidine and spermine their diamine precursor putrescine are essential for mammalian cell growth viability, strategies sought reducing polyamine levels in order to inhibit cancer growth. Several structural analogues of the have been found decrease natural growth, probably by stimulating normal feedback mechanisms. In present study, a large selection has tested effectiveness inducing production antizyme, key protein inhibition synthesis cellular uptake. Bisethylnorspermine,...
Abstract There is growing interest in utilizing pharmacogenetic (PGx) testing to guide antidepressant use, but there lack of clarity on how implement into clinical practice. We administered two surveys at 17 sites that had implemented or were the process implementing PGx for antidepressants. Survey 1 collected data and logistics testing. 2 asked rank importance Consolidated Framework Implementation Research (CFIR) constructs using best‐worst scaling choice experiments. Of sites, 13 four...
COVIDTrach is a UK multicentre prospective cohort study project that aims to evaluate the outcomes of tracheostomy in patients with COVID-19 receiving mechanical ventilation and record incidence SARS-CoV-2 infection among healthcare workers involved procedure.Data on patient demographic, clinical history were entered prospectively updated over time via an online database (REDCap). Clinical variables compared outcomes, logistic regression used develop model for mortality. Participants...
Aim: Understanding barriers and facilitators to pharmacogenomics (PGx) implementation how structure a clinical program with the Veterans Health Administration (VA). Materials & methods: Healthcare provider (HCP) survey at 20 VA facilities assessing PGx knowledge/acceptance qualitative interviews understand best design sustain national program. Results: 186 (12% response rate) surveyed believed informs drug efficacy (74.7%) adverse events (71.0%). Low confidence in knowledge (43.0%) ability...
Background: Pharmacy practice models that foster pharmacists’ accountability for medication-related outcomes are imperative the profession. Comprehensive medication management (CMM) is an opportunity to advance patient care. Objective: The objective of this study was evaluate impact a CMM model in acute care setting on organizational, patient, and financial outcomes. Methods: Three adult service lines focused at-risk patients identified using internal risk stratification methodology were...
Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how implement in clinical practice. Best-worst scaling (BWS) a stated preferences technique determining relative importance of alternative scenarios and increasingly being used as healthcare assessment tool, with potential applications implementation research. We conducted BWS experiment evaluate factors PGx use.We surveyed 17 organizations that either had implemented or were...
To describe the implementation of clinical decision support tools for alerting prescribers actionable drug-gene interactions in Veterans Health Administration (VHA).Drug-gene have been focus clinicians years. Interactions between SCLO1B1 genotype and statin medications are particular interest as these can inform risk statin-associated muscle symptoms (SAMS). VHA identified approximately 500,000 new users prescribed fiscal year 2021, some whom could benefit from pharmacogenomic testing gene....
Background Healthcare systems and policy makers worldwide are demonstrating interest in shared decision making, which requires patient activation. Patient activation can be measured using a validated tool called the measure-10. First cycle comprehensive chemotherapy consultation services (3CS) is provided by an oncology pharmacy team member during encounter at beginning of patient's treatment for cancer. Methods This was single center, prospective, non-randomized, observational clinical...
Aim: The first Plan-Do-Study-Act cycle for the Veterans Affairs Pharmacogenomic Testing pharmacogenomic clinical testing program is described. Materials & methods: Surveys evaluating implementation resources and processes were distributed to teams, providers, laboratory health informatics staff. Survey responses mapped Consolidated Framework Implementation Research constructs identify barriers. Expert Recommendation Implementing Change strategies used address Results: response rate was...
The impact of converting to the isotope dilution mass spectrometry (IDMS)-traceable serum creatinine (SCr) assay for determining calculated and delivered dose carboplatin was studied.A single-center, retrospective, observational chart review adult patients who received a within one month before after implementation IDMS-traceable SCr conducted using information available in medical records chemotherapy orders. Patient-specific data were collected used calculate change Cockcroft-Gault...
Abstract Response to analgesic therapy is influenced by several factors including genetics and drug–drug interactions. Pharmacogenetic (PGx) variants in the CYP2D6 gene modify response opioids altering drug metabolism. We sought determine potential impact of PGx testing on care Veterans with noncancer pain prescribed metabolized (codeine, hydrocodone, or tramadol). A retrospective analysis was performed within Health Administration evaluating prescription records for medications interacting...