A5041254417- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Platelet Disorders and Treatments
- Urinary Tract Infections Management
- Attention Deficit Hyperactivity Disorder
- Cancer Treatment and Pharmacology
- Gastroesophageal reflux and treatments
- Antibiotic Resistance in Bacteria
- Blood disorders and treatments
- Health and Medical Research Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Hormonal Regulation and Hypertension
- Neonatal Health and Biochemistry
- Autism Spectrum Disorder Research
- Cancer survivorship and care
- Acute Lymphoblastic Leukemia research
- Chemotherapy-related skin toxicity
- Innovations in Medical Education
- Electronic Health Records Systems
- Methemoglobinemia and Tumor Lysis Syndrome
- Chronic Myeloid Leukemia Treatments
- Metabolomics and Mass Spectrometry Studies
- Antiplatelet Therapy and Cardiovascular Diseases
University of Florida
2020-2024
Arkansas Children's Hospital
2021-2024
Florida College
2020-2024
AdventHealth Orlando
2019
The increased availability of clinical pharmacogenetic (PGx) guidelines and decreasing costs for genetic testing have slowly led to utilization PGx in practice. Pre-emptive testing, where is performed advance drug prescribing, one means ensure results are available at the time prescribing decisions. However, most efficient effective methods clinically implement this strategy remain unclear.In report, we compare contrast implementation strategies pre-emptive by 15 early-adopter institutions....
Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is associated with development of acute hemolytic anemia in the setting oxidative stress, which can be caused by medication exposure. Regulatory agencies worldwide warn against use certain medications persons G6PD deficiency, but many cases, this information conflicting, and clinical evidence sparse. This guideline provides on using genotype as part diagnosis classifies that have been previously implicated unsafe individuals one or more...
Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical decisions. This article describes the development of an outpatient, pharmacist-led, pharmacogenetics consult clinic within internal medicine, its workflow, and early results, along with successes challenges. A pharmacogenetics-trained pharmacist encouraged primary care physicians (PCPs) refer patients who were experiencing side effects/ineffectiveness from certain antidepressants, opioids, and/or proton pump...
To describe the implementation of CYP2C19 testing into clinical practice at University Florida (UF) Health Gainesville hospital to guide proton pump inhibitor (PPI) dosing and lessons learned from this experience.Different genotypes are associated with variability in PPI plasma concentrations intragastric pH, which may contribute risk treatment failure due subtherapeutic adverse effects (eg, infection, bone fracture, renal dysfunction) sustained supratherapeutic concentrations. Based on...
Abstract There is growing interest in utilizing pharmacogenetic (PGx) testing to guide antidepressant use, but there lack of clarity on how implement into clinical practice. We administered two surveys at 17 sites that had implemented or were the process implementing PGx for antidepressants. Survey 1 collected data and logistics testing. 2 asked rank importance Consolidated Framework Implementation Research (CFIR) constructs using best‐worst scaling choice experiments. Of sites, 13 four...
The University of Florida Health conducted a pragmatic implementation pharmacogenetics (PGx) panel-based test to guide medications used for supportive care prescribed patients undergoing chemotherapy. was in the context clinical trial with non-hematologic cancers being treated Patients were randomized either intervention arm or control and received PGx testing immediately at end study, respectively. completed MD Anderson Symptom Inventory (MDASI) assess quality life (QoL). A total 150...
Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how implement in clinical practice. Best-worst scaling (BWS) a stated preferences technique determining relative importance of alternative scenarios and increasingly being used as healthcare assessment tool, with potential applications implementation research. We conducted BWS experiment evaluate factors PGx use.We surveyed 17 organizations that either had implemented or were...
Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual’s genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations response, pharmacogenetic testing has not been widely implemented into practice. Among the barriers broad implementation are limited guidance for how successfully integrate workflows data The Pharmacogenomics Global Research Network...
A formal assessment of pharmacogenomics clinical decision support (PGx-CDS) by providers is lacking in the literature. The objective this study was to evaluate usability PGx-CDS tools that have been implemented a healthcare setting. We enrolled ten prescribing and had them complete 60-min session, which included interacting with two scenarios using “Think Aloud” technique, as well completing Computer System Usability Questionnaire (CSUQ). Providers reported positive comments, negative...
Neurodevelopmental disorders have steadily increased in incidence the United States. Over past decade, there been significant changes clinical diagnoses and treatments some of which are due to increasing adoption pharmacogenomics (PGx) by clinicians. In this pilot study, a multidisciplinary team at Arkansas Children's Hospital North West consulted on 27 patients referred for difficult-to-manage neurodevelopmental and/or neurobehavioral disorders. The were evaluated using records review,...
Abstract Background Options for treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections were historically limited to antibiotics with efficacy and significant toxicities. Ceftazidime/avibactam (CA) meropenem/vaborbactam (MV) are superior older regimens; however, a direct comparison the agents is lacking. This study compared clinical outcomes including recurrence infection emergence drug resistance in patients who received CA vs. MV CRE infections. Methods was multicenter,...
Abstract Introduction Clinical pharmacogenomics is a required element in the Doctor of Pharmacy (Pharm.D.) curriculum. However, not widely adopted into clinical practice and as such, considerable variability teaching learning activities within pharmacogenomic advanced pharmacy experiences (APPE) exist. Among other places University Florida's Pharm.D. curriculum, practical applications are covered during APPE year through an elective 6‐week Pharmacogenomics APPE. Objectives Describe our...
INTRODUCTION: Dual-antiplatelet therapy (DAPT) is clinically indicated for patients undergoing endovascular procedures. Clopidogrel the most commonly used P2Y12 inhibitor DAPT, and a prodrug bioactivated by CYP2C19 enzyme. Inferring platelet response can be done genotyping to determine metabolizer status. Patients with two functional alleles are considered normal metabolizers (NM), one or increased activity rapid (RM) ultra-rapid (UM), respectively, loss-of-function (LOF) intermediate (IM)...