A5056542161- Cannabis and Cannabinoid Research
- Pharmacogenetics and Drug Metabolism
- Poisoning and overdose treatments
- Forensic Toxicology and Drug Analysis
- Homelessness and Social Issues
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
- Acute Ischemic Stroke Management
- Psychedelics and Drug Studies
- COVID-19 Clinical Research Studies
- Opioid Use Disorder Treatment
- Pharmaceutical studies and practices
- Long-Term Effects of COVID-19
- Pharmaceutical Practices and Patient Outcomes
- Blood Pressure and Hypertension Studies
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Marriage and Sexual Relationships
- Emergency and Acute Care Studies
- Alcohol Consumption and Health Effects
- Genomics and Rare Diseases
- Alcoholism and Thiamine Deficiency
- Neuroinflammation and Neurodegeneration Mechanisms
University of Colorado Denver
2016-2025
Denver Health Medical Center
2016-2025
University of Colorado Anschutz Medical Campus
2016-2025
Health and Hospital Corporation
2016-2024
Metropolitan University
2024
University of Colorado Hospital
2011-2023
University at Buffalo, State University of New York
2023
Washington Poison Center
2010-2023
University of Montana
2014-2023
Boston Children's Museum
2022-2023
Opioids are mainly used to treat both acute and chronic pain. Several opioids metabolized some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, methadone). Polymorphisms in have been studied for an association with the clinical effect safety of these drugs. Other genes that their opioid or adverse events include OPRM1 (mu receptor) COMT (catechol‐O‐methyltransferase). This guideline updates expands 2014 Clinical Pharmacogenetics Implementation Consortium (CPIC) genotype codeine...
Background: Little is known about the relative harms of edible and inhalable cannabis products. Objective: To describe compare adult emergency department (ED) visits related to inhaled exposure. Design: Chart review ED between 1 January 2012 31 December 2016. Setting: A large urban academic hospital in Colorado. Participants: Adults with a cannabis-related International Classification Diseases, Ninth or 10th Revision, Clinical Modification (ICD-9-CM ICD-10-CM), code. Measurements: Patient...
The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. We report here a multiomics investigation systemic IFN in hospitalized patients, defining the biosignatures associated varying levels 12 different type I, II, III IFNs. antiviral transcriptional response circulating immune cells is strongly specific subset IFNs, most prominently IFNA2 IFNG. In contrast, proteomics signatures indicative endothelial damage...
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Abstract Objectives Case reports have described a syndrome of cyclic vomiting associated with chronic marijuana use, termed cannabinoid hyperemesis syndrome. The primary objective was to determine the prevalence patients presenting before and after liberalization medical in Colorado 2009. secondary describe odds use among visits these same time periods. Methods This cross‐sectional study emergency department ( ED ) liberalization. International Classification Diseases, ninth revision, coding...
Red blood cells (RBCs) are key players in systemic oxygen transport. RBCs respond to vitro hypoxia through the so-called oxygen-dependent metabolic regulation, which involves competitive binding of deoxyhemoglobin and glycolytic enzymes N-terminal cytosolic domain band 3. This mechanism promotes accumulation 2,3-DPG, stabilizing deoxygenated state hemoglobin, cytosol acidification, triggering off-loading Bohr effect. Despite studies, vivo adaptations have not yet been completely elucidated....
Since the onset of SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR1. Host epigenome manipulation post coronavirus infection2-4 suggests that DNA methylation signatures may differentiate patients with infection from uninfected individuals, and help predict COVID-19 disease severity, even at initial presentation.We customized Illumina's Infinium MethylationEPIC array to enhance immune response detection profiled peripheral blood samples 164 longitudinal measurements severity...
Cannabis legalization in Colorado resulted increased cannabis-associated health care utilization. Our objective was to examine cooccurrence of cannabis and mental diagnostic coding emergency department (ED) discharges replicate the study a subpopulation ED visits where involvement psychiatric diagnosis were confirmed through medical review.We collected statewide International Classification Diseases, 9th Revision, Clinical Modification diagnoses from Hospital Association large, academic...
COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechanisms driving these lack of staging biomarkers hamper ability to stratify patients for targeted therapeutics. We report here results cross-sectional multi-omics analysis hospitalized revealing that seroconversion status associates with distinct...
COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. To expedite integrated collaborative research, we completed multi-omics analysis hospitalized patients, including matched the whole-blood transcriptome, plasma proteomics with two complementary platforms, cytokine profiling, red blood cell metabolomics, deep immune phenotyping by mass cytometry, clinical data annotation. We refer to this multidimensional dataset as COVIDome. then created...
Neuroinflammation is ubiquitous in acute stroke and worsens outcome. However, the precise timing of inflammatory response unknown, hindering design anti-inflammatory therapeutic interventions. We sought to identify onset neuroinflammatory cascade using a mobile unit.
ABSTRACT The purpose of this article was to characterize practices buprenorphine/naloxone (B/N) diversion in a region with high prescribing prevalence. A cross-sectional, open-ended survey administered individuals entering opioid addiction treatment programs two New England states. authors obtained formative information about the knowledge, attitudes, beliefs, practices, and street economy B/N diversion. interviewed 51 individuals, 49 which were aware medication. Of that number, 100% had...