A5073766762- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Machine Learning in Bioinformatics
- Chromosomal and Genetic Variations
- Cancer-related Molecular Pathways
- Genomics and Phylogenetic Studies
- Histone Deacetylase Inhibitors Research
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Immune responses and vaccinations
- Gut microbiota and health
- Wound Healing and Treatments
- Genomics and Rare Diseases
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Tendon Structure and Treatment
- Allergic Rhinitis and Sensitization
- Plant Disease Resistance and Genetics
- 14-3-3 protein interactions
- Cytokine Signaling Pathways and Interactions
- Bioinformatics and Genomic Networks
University of Colorado Anschutz Medical Campus
2021-2024
University of Colorado Denver
2014-2024
University of California, Santa Barbara
2007-2010
Since the onset of SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR1. Host epigenome manipulation post coronavirus infection2-4 suggests that DNA methylation signatures may differentiate patients with infection from uninfected individuals, and help predict COVID-19 disease severity, even at initial presentation.We customized Illumina's Infinium MethylationEPIC array to enhance immune response detection profiled peripheral blood samples 164 longitudinal measurements severity...
Bridging the gap between genetic variations, environmental determinants, and phenotypic outcomes is critical for supporting clinical diagnosis understanding mechanisms of diseases. It requires integrating open data at a global scale. The Monarch Initiative advances these goals by developing ontologies, semantic models, knowledge graphs translational research. App an integrated platform combining about genes, phenotypes, diseases across species. Monarch's APIs enable access to carefully...
Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal Consortium on among African-ancestry Populations in Americas (CAAPA) to understand multi-omic signatures asthma focusing populations African ancestry. RNASeq DNA methylation data are generated from nasal epithelium including cases (current asthma, N = 253) controls (never-asthma, 283) 7 different geographic sites identify...
Carbendazim (methyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food production and appears to act on fungal tubulin. However, it also inhibits proliferation of cancer cells, including drug- multidrug-resistant p53-deficient cell lines. Because its promising preclinical anti-tumor activity, has undergone phase I clinical trials under further development. Although weakly polymerization brain microtubules induces G<sub>2</sub>/M arrest tumor mechanism action cells...
Abstract Background Previously, 3% of the human genome has been annotated as simple sequence repeats (SSRs), similar to proportion protein coding. The origin much is not well annotated, however, and some unidentified regions are likely be ancient SSR-derived identified by current methods. identification these complicated because SSRs appear evolve through complex cycles expansion contraction, often interrupted mutations that alter both repeated motif mutation rate. We applied an empirical,...
Abstract Secondary resistance to hormonal therapy for breast cancer commonly develops after an initial response tamoxifen or aromatase inhibitors. Agents abrogate these adaptive changes would substantially enhance the long-term benefits of therapy. Our studies with a stilbene derivative called TMS (2,3′,4,5′-tetramethoxystilbene) identified unexpected effects potential utility treatment tumors secondarily resistant was originally developed as inhibitor cytochrome P450 1B1 block conversion...
NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln) is a neuroprotective peptide that shows cognitive protection in patients with amnestic mild impairment, precursor to Alzheimer's disease. exhibits potent properties several vivo and cellular models of neural injury. While has been found many studies affect microtubule assembly and/or stability neuronal glial cells at fM concentrations, it remained unclear whether acts directly or indirectly on tubulin microtubules. We analyzed the effects (1 fM-1 microM)...
Most common methods for inferring transposable element (TE) evolutionary relationships are based on dividing TEs into subfamilies using shared diagnostic nucleotides. Although originally justified the "master gene" model of TE evolution, computational and experimental work indicates that many generated by these contain multiple source elements. This implies subfamily-based give an incomplete picture relationships. Studies selection, functional exaptation, predictions horizontal transfer may...
Abstract Since the onset of SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR. Host epigenome manipulation post coronavirus infection suggests that DNA methylation signatures may differentiate patients with from uninfected individuals, and help predict COVID-19 disease severity, even at initial presentation. We customized Illumina’s Infinium Methylation EPIC array to enhance immune response detection profiled peripheral blood samples 164 longitudinal measurements severity 296...
Supplementary Figure 2 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 7 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 8 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 5 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 1 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 3 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 4 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
<div>Abstract<p>Secondary resistance to hormonal therapy for breast cancer commonly develops after an initial response tamoxifen or aromatase inhibitors. Agents abrogate these adaptive changes would substantially enhance the long-term benefits of therapy. Our studies with a stilbene derivative called TMS (2,3′,4,5′-tetramethoxystilbene) identified unexpected effects potential utility treatment tumors secondarily resistant was originally developed as inhibitor cytochrome P450 1B1...
Supplementary Figure Legends 1-8, supplementary discussion from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 6 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 7 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action
Supplementary Figure 5 from Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms Action