A5046488005- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- PARP inhibition in cancer therapy
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Advances in Oncology and Radiotherapy
- Economic and Financial Impacts of Cancer
- Colorectal and Anal Carcinomas
- Estrogen and related hormone effects
- Lung Cancer Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemotherapy-related skin toxicity
- Radiation Therapy and Dosimetry
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
University of Florida
2015-2025
Florida College
2015-2024
University of Florida Health
2020-2024
UF Health Cancer Center
2020-2024
Innovating Health International
2018
Karen Hospital
2018
Methodist Hospital
2017
Winship Cancer Institute
2017
Indiana University Health
2017
Georgetown University
2017
A significant proportion of patients with early-stage triple-negative breast cancer (TNBC) are treated neoadjuvant chemotherapy. Sequencing circulating tumor DNA (ctDNA) after surgery, along enumeration cells (CTCs), may be used to detect minimal residual disease and assess which experience recurrence.To determine whether the presence ctDNA CTCs chemotherapy in TNBC is independently associated recurrence clinical outcomes.A preplanned secondary analysis was conducted from March 26, 2014,...
Prior research suggests that breast cancer patients with a high burden of frailty may face an increased risk cardiotoxicity. This study sought to examine the association between and cardiotoxicity rates in female receiving adjuvant therapy after surgery. We analyzed data from OneFlorida+ clinical network, focusing on treated chemotherapy targeted 2012 2022. Cardiovascular during treatments were calculated based pre-existing frailty, measured using cumulative deficit index (electronic health...
The risk for monkeypox transmission to health care personnel (HCP) caring symptomatic patients is thought be low but has not been thoroughly assessed in the context of current global outbreak (1). Monkeypox typically spreads through close physical (often skin-to-skin) contact with lesions or scabs, body fluids, respiratory secretions a person an active infection. CDC currently recommends that HCP wear gown, gloves, eye protection, and N95 (or higher-level) respirator while suspected...
Patients with triple-negative breast cancer (TNBC) residual disease after neoadjuvant chemotherapy (NAC) have high risk of recurrence prior data suggesting improved outcomes capecitabine. Targeted agents demonstrated activity across multiple types. BRE12-158 was a phase II, multicenter trial that randomly allocated patients TNBC NAC to genomically directed therapy versus treatment physician choice (TPC).From March 2014 December 2018, 193 were enrolled. Residual tumors sequenced using...
Summary: Community-level projects are a cornerstone in efforts to provide medical care unhoused populations. The Community Medicine Cabinet (CMC) is novel program created supply residents of local warming shelter with access free over-the-counter medications. This report details the initial 18 months operation including patient-reported evaluations.
There have been significant advancements in precision medicine and approaches to medication selection based on pharmacogenetic results. With the availability of direct‐to‐consumer genetic testing growing awareness interindividual variability, patient demand for more precise, individually tailored drug regimens is increasing. The University Florida (UF) Health Precision Medicine Program (PMP) was established 2011 improve integration genomic data into clinical practice. In ensuing years, UF...
3122 Background: BRCA1-Associated Protein 1 (BAP1) acts as a tumor suppressor and critical regulator of the cell cycle DNA damage response (DDR). PARP inhibitors (PARPi) demonstrate synthetic lethality in BAP1 mutant (mBAP1) preclinical models, independent underlying germline BRCA status. mBAP1 leads to loss functional protein several solid tumors. This study aimed explore clinical activity niraparib patients (pts) with advanced tumors likely harbor mBAP1. Methods: Eligible adult pts...
The University of Florida Health conducted a pragmatic implementation pharmacogenetics (PGx) panel-based test to guide medications used for supportive care prescribed patients undergoing chemotherapy. was in the context clinical trial with non-hematologic cancers being treated Patients were randomized either intervention arm or control and received PGx testing immediately at end study, respectively. completed MD Anderson Symptom Inventory (MDASI) assess quality life (QoL). A total 150...
Little is known about the epidemiology of breast cancer in developing countries, and Haiti has perhaps least data any country Western Hemisphere.
A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature presentation, suspicion gemcitabine-induced capillary leak syndrome was included in differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9–86 pg/mL). Corticosteroids initiated, resulting complete resolution symptoms hypotension. The patient suffered...
Hepatoid adenocarcinoma (HAC) is a rare extrahepatic that morphologically and immunophenotypically mimics hepatocellular carcinoma (HCC). We report the case of 42-year-old woman with an extensive cancer history who presented right-sided abdominal pain lower gastrointestinal (GI) bleeding, was ultimately diagnosed colon adenocarcinoma. She underwent sigmoidectomy adjuvant chemotherapy. Approximately 1 month after completion chemotherapy, positron emission tomography showed presence 1.8 cm×1.4...
TPS591 Background: BRCA1-Associated Protein 1 (BAP1) is a critical regulator of the cell cycle, cellular differentiation, death, and DNA damage response. It also acts as tumor suppressor. Preclinical models demonstrate significant synthetic lethality in BAP1 mutant lines patient xenografts when treated with PARP inhibitors, independent underlying BRCA status, suggesting this mutation confers BRCA-like phenotype. mutated, leading to loss functional protein, up 30% cholangiocarcinomas well...
Abstract Background Undergoing cancer screening is a debatable topic in patients with cognitive impairment. In this study, we aimed to examine the utilization and predictors of breast colorectal among eligible, cognitively impaired individuals. Methods We analyzed 2018 2019 National Health Interview Survey data ( n = 12,965 24,782, respectively) on individuals eligible for or screening. calculated percentage who received mammogram colonoscopy by impairment status. used multivariable logistic...
Preclinical studies have demonstrated that Src inhibition through dasatinib synergistically enhances the antitumor effects of oxaliplatin. In this phase II, single-arm study, FOLFOX with in previously untreated patients mPC only showed modest clinical activity, a progressive-free survival 4 months and overall 10.6 months. Continued investigation is ongoing to better understand role concurrent 5-fluorouracil oxaliplatin subset exceptional responders.Src tyrosine kinase activity overexpressed...
Acinic cell carcinoma of the breast is a rare subtype triple-negative cancer that recapitulates appearance tumors seen in salivary glands. We present case 42-year-old woman with an irregular, nontender mass above left nipple during routine obstetric appointment at 24 weeks gestation. She was subsequently diagnosed invasive ductal breast, Nottingham grade 3, via core needle biopsy. treated neoadjuvant therapy (doxorubucin and cyclophosphamide) antenatally paclitaxel postpartum period followed...
BRCA1-associated protein 1 (BAP1) is a critical cell cycle and DNA damage response (DDR) regulator with mutations (mBAP1) causing functional loss. PARP inhibitors (PARPis) demonstrate synthetic lethality in mBAP1 preclinical models, independent of underlying BRCA status. This study aimed to explore the clinical activity niraparib patients advanced tumors likely harbor mBAP1.
Chemotherapy and targeted therapies are effective palliative options for numerous unresectable or metastatic cancers. However, treatment resistance inevitably develops leading to mortality. In a subset of patients, systemic therapy appears control the majority tumors leaving 5 less progress, phenomenon described as oligoprogression. Reasoning that lesions remain responsive ongoing chemotherapy, we hypothesized local progressing would confer benefit. The present study describes cases patients...
e15201 Background: Survival after pancreatic adenocarcinoma (PCa) resection is only 20% despite adjuvant therapy. Neoadjuvant treatment (NAT) cost effective, may improve R0 rates and overall survival through earlier systemic Methods: Pts in this prospective pII study were assigned to low-risk (Grp 1) or high-risk/borderline-resectable 2) groups (as published by NCCN consensus). Cycles consisted of G 1,000mg/m2 A 100mg/m2 on D1, 8, 15 q28d. Grp 1 = 3 cycles G+A followed resection. 2 weeks...