A5078632304- Acute Kidney Injury Research
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Liver Disease and Transplantation
- Multiple Myeloma Research and Treatments
- Cytomegalovirus and herpesvirus research
- Acute Myocardial Infarction Research
- Retinoids in leukemia and cellular processes
- Chemotherapy-induced cardiotoxicity and mitigation
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Neuroendocrine Tumor Research Advances
- Cancer Risks and Factors
- Congenital Diaphragmatic Hernia Studies
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Dermatological and COVID-19 studies
- Pediatric health and respiratory diseases
- Clinical Nutrition and Gastroenterology
- Apelin-related biomedical research
- Diet, Metabolism, and Disease
- Platelet Disorders and Treatments
Fuzhou University
2021-2025
College of Central Florida
2020
University of Central Florida
2016-2020
Regional Medical Center
2020
University of Arizona
2020
Saint Luke's Health System
2020
Florida College
2020
AdventHealth Orlando
2016-2020
University of Florida
2005-2020
University of Missouri–Kansas City
2020
Thrombocytopenia after allogeneic hematopoietic stem cell transplantation (allo-SCT) can pose significant problems in management of patients. Eltrombopag is a small-molecule thrombopoietin receptor agonist that has been approved for use immune thrombocytopenic purpura and aplastic anemia; but its allo-SCT limited. Between 2014 2017, we treated 13 patients with eltrombopag poor platelet engraftment without evidence relapse at the time initiation, including 6 primary failure 7 secondary...
Introduction Contrast-induced acute nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI) the setting of syndromes (ACS) is associated with adverse outcomes, including longer hospitalization and short long-term mortality. Neutrophil to lymphocyte ratio (NLR) platelet (PLR) are inflammatory markers that have been validated separately prior studies as a predictor CIN ACS who undergo left heart catheterization. Our study aims further investigate role NLR PLR together...
BACKGROUND:ALK gene rearrangements as oncogenic drivers have been described in many cancers, including inflammatory myofibroblastic sarcoma (IMS). The first-generation ALK inhibitor was limited its ability to cross the blood-brain-barrier treat brain metastasis. Drug-resistance invariably develops over time ALK-rearranged tumors, which leads disease progression. newer generations of inhibitors are designed higher potency inhibition and improved CNS penetration. CASE REPORT:We report a rare...
Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening syndrome resulting from excessive immune activation. Secondarily, HLH often associated with autoimmune disease, infection, and malignancy. The most common infectious trigger Epstein-Barr virus (EBV) infection. rarely triggered by parvovirus B19. We discuss case of 62-year-old male who presented multi-organ failure presumed septic shock eventually was diagnosed HLH, positive B19 deoxyribonucleic acid (DNA) polymerase...
Abstract Aims Alteplase is a cornerstone thrombolytic agent in clinical practice but presents potential bleeding risk. Stroke patients need pre-screening to exclude haemorrhagic stroke before using alteplase. In this study, we develop new citPA5, characterized by an enhanced safety profile and minimal tendency. Methods results A clot lysis agent, named developed based on rtPA with point mutations completely suppress its proteolytic activity the absence of fibrin. presence fibrin, citPA5...
Abstract Progressive multifocal leukoencephalopathy ( PML ) is a rare, yet typically fatal complication of allogeneic stem cell transplantation. It caused by reactivation the John Cunningham JC virus in an immunocompromised host. This report describes unfortunate case recipient transplant for acute myelogenous leukemia. The was undetectable patient's cerebrospinal fluid polymerase chain reaction PCR ); however, positive diagnosis made after brain biopsy. and other published cases demonstrate...
Programmed cell death protein-1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors induce tumor response by activating the patient's own immune system to fight cancer. Tumors with high mutational burden or those that express levels of PD-1/PD-L1 are more responsive PD1/PDL1 inhibitors. There is much interest in determining how improve We report a case patient metastatic bladder cancer who was primarily resistant treatment inhibitors, then had complete after developing...
Benign metastasizing leiomyoma is a very uncommon clinicopathologic entity with unknown molecular pathogenesis. We present case of 40-year-old woman who has history surgical resection large uterine and then subsequently presented benign leiomyomas to her lungs. Due tumor being estrogen receptor (ER) positive progesterone (PR) positive, she was empirically treated anastrozole sustained clinical benefit. Molecular studies Foundation One testing showed low mutational burden variants in five...
Abstract Current oral anticoagulants prescribed for the prevention of thrombosis suffer from severe hemorrhagic problems. Coagulation factor XIa (FXIa) has been confirmed as a safer antithrombotic target intervention with FXIa causes lower risks. In this study, by high-throughput virtual screening, we identified Montelukast (MK), an antiasthmatic drug, potent and specific inhibitor (IC 50 = 0.17 µM). Compared two mostly (Warfarin Apixaban), MK demonstrated comparable or even higher effects...
Abstract Rationale, aims, and objectives Several studies have looked at patient‐related variables influencing hospital length of stay (LOS) in patients with acute exacerbations chronic obstructive pulmonary disease (AECOPD). However, there has been increasing recognition that physician‐related factors also play a significant role. This study aims to evaluate differences practice patterns between teaching nonteaching services their effect on LOS large community hospital. Methods A...
Background: Relapse of disease following allogeneic stem cell transplantation Allo-SCT is a major cause treatment failure in AML and MDS prognosis these patients poor. De Lima et al., showed that post-transplant low-dose Azacitidine (AZA) high-risk who were transplanted with reduced-intensity conditioning (RIC) regimen, improved GVL effect decreased severe GVHD.1 DNA methyltransferase inhibitor activity myeloid malignancies including AML.2 Given the safety pos-transplant setting, we...