A5011907942- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Intensive Care Unit Cognitive Disorders
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Phosphodiesterase function and regulation
- Neural dynamics and brain function
- Cardiac Arrest and Resuscitation
- Pharmacological Effects and Toxicity Studies
- Neurotransmitter Receptor Influence on Behavior
- Respiratory Support and Mechanisms
King's College London
2017-2025
The Recovery Center
2022
Wellcome Centre for Human Neuroimaging
2017
Goldsmiths University of London
2010
White matter disruption is an important determinant of cognitive impairment after brain injury, but conventional neuroimaging underestimates its extent. In contrast, diffusion tensor imaging provides a validated and sensitive way identifying the impact axonal injury. The relationship between traumatic injury white damage likely to be complex. We applied flexible technique—tract-based spatial statistics—to explore whether specific tracts associated with particular patterns impairment....
<h3>Importance</h3> Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness safety of these noninvasive strategies. <h3>Objective</h3> To determine whether either CPAP or HFNO, compared conventional therapy, improves clinical outcomes hospitalized COVID-19–related failure. <h3>Design, Setting, Participants</h3> A parallel group,...
Abstract Recent studies have shown that drug‐induced spatial alteration patterns in resting state functional activity as measured using magnetic resonance imaging (rsfMRI) are associated with the distribution of specific receptor systems targeted by respective compounds. Based on this approach, we introduce a toolbox (JuSpace) allowing for cross‐modal correlation MRI‐based measures nuclear derived estimates covering various neurotransmitter including dopaminergic, serotonergic,...
Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link observed alterations to specific neurophysiological processes. In particular, sensitivity activity changes neurotransmitter systems remains unclear. We address this question probing healthy volunteers using seven established drugs with known dopaminergic, serotonergic, glutamatergic and GABAergic mechanisms action. use a novel framework aimed at...
Cognitive dysfunction is common in depression during both acute episodes and remission. Vortioxetine a novel multimodal antidepressant that has improved cognitive function including executive depressed patients randomised placebo-controlled clinical trials. However, it unclear whether vortioxetine able to target directly the neural circuitry implicated deficits depression. Remitted (n=48) healthy volunteers were receive 14 days treatment with 20 mg or placebo double-blind design. The effects...
Abstract Activity changes within the anterior cingulate cortex (ACC) are implicated in antidepressant effects of ketamine, but ACC is cytoarchitectonically and functionally heterogeneous ketamine’s may be subregion specific. In context a double-blind randomized placebo-controlled crossover trial investigating clinical resting-state fMRI intravenous ketamine vs. placebo patients with treatment resistant depression (TRD) healthy volunteers (HV), we used seed-based functional connectivity...
Abstract Chronic administration of antipsychotic drugs has been linked to structural brain changes observed in patients with schizophrenia. Recent MRI studies have shown rapid regional volume following just a single dose these drugs. However, it is not clear if represent real or are artefacts (“apparent” changes) due drug‐induced physiological changes, such as increased cerebral blood flow (CBF). To address this, we examined the effects single, clinical three commonly prescribed...
Abstract Recent studies have shown that drug-induced spatial alteration patterns in resting state functional activity as measured using magnetic resonance imaging (rsfMRI) are associated with the distribution of specific receptor systems targeted by respective compounds. Based on this approach, we introduce a toolbox (JuSpace) allowing for cross-modal correlation MRI- based measures nuclear derived estimates covering various neurotransmitter including dopaminergic, serotonergic,...
Ketamine as an antidepressant improves anhedonia early 2 hours after infusion. These drug effects are thought to be exerted via actions on reward-related brain areas-yet these remain largely unknown. Our study investigates ketamine's during the anticipation and receipt of expected reward, psychotomimetic ketamine have passed, when reported.We examined rewards predefined areas, namely, dorsal ventral striatum, tegmental area, amygdala, insula. We recruited 37 male female participants with...
Abstract Dopamine (DA) mediated brain activity is intimately linked to reward‐driven cerebral responses, while aberrant reward processing has been implicated in several psychiatric disorders. fMRI a valuable tool understanding the mechanism by which DA modulators alter responses and how they may exert their therapeutic effect. However, potential effects of pharmacological compound on aspects neurovascular coupling cloud interpretability BOLD contrast. Here, we assess risperidone driven...
Background: Cognitive flexibility deficits are present in patients with schizophrenia and strong predictors of functional outcome but, as yet, have no pharmacological treatments. Aims: The purpose this study was to investigate whether the phosphodiesterase type-4 inhibitor, roflumilast, can improve cognitive performance brain activity schizophrenia. Methods: This a within-subject, randomised, double-blind, placebo-controlled, three-period crossover using version...
Abstract Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link observed alterations to specific neurophysiological processes. In particular, sensitivity activity changes neurotransmitter systems remains unclear. We address this question probing healthy volunteers using seven established drugs with known dopaminergic, serotonergic, glutamatergic and GABAergic mechanisms action. use a novel framework...
Abstract Ketamine as an antidepressant improves anhedonia, a pernicious symptom of depression early 2h post-infusion. The effects ketamine on anhedonia are thought to be exerted via actions reward-related brain areas—yet, these remain largely unknown. This study examines ketamine’s during the anticipation and receipt expected reward, after psychotomimetic have passed, when reported. In order identify areas that modulated by drug per se not linked changes, we recruited 37 participants who...
Abstract As a result of neuro-vascular coupling, the functional effects antipsychotics in human brain have been investigated both healthy and clinical populations using haemodynamic markers such as regional Cerebral Blood Flow (rCBF). However, relationship between observed pharmacological action these drugs has not fully established. Here, we analysed MRI-based rCBF data from placebo-controlled study volunteers, who received single dose three different D2 receptor antagonists tested...
Previous studies measuring cerebral blood flow (CBF) with magnetic resonance sequences like Arterial Spin Labelling (ASL) showed that patients schizophrenia (SCZ) have increased CBF in basal ganglia and reduced cortical areas the prefrontal cortex. It is still not clear whether these abnormalities are related to antipsychotic treatment or rather they reflect a disease trait independent from medication. Interestingly, administration of single dose antipsychotics healthy volunteers produce...