A5065248098- Global Maternal and Child Health
- Child Nutrition and Water Access
- Malaria Research and Control
- Iron Metabolism and Disorders
- HIV/AIDS Research and Interventions
- Hemoglobinopathies and Related Disorders
- Breastfeeding Practices and Influences
- Mosquito-borne diseases and control
- Adolescent Sexual and Reproductive Health
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- HIV-related health complications and treatments
- Neonatal and fetal brain pathology
- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- Healthcare Systems and Reforms
- Parasites and Host Interactions
- Respiratory viral infections research
- Child Nutrition and Feeding Issues
- Parasitic Infections and Diagnostics
- Emergency and Acute Care Studies
- Prenatal Screening and Diagnostics
- Infant Nutrition and Health
- Homelessness and Social Issues
- Helicobacter pylori-related gastroenterology studies
Makerere University
2016-2025
Naguru General Hospital
2024
Kampala International University
2024
Kabale University
2024
Baylor College of Medicine Children’s Foundation
2023
Carol Davila University of Medicine and Pharmacy
2023
Mulago Hospital
2005-2023
Karolinska Institutet
2023
Busitema University
2022
University of Juba
2021
Cryptosporidium spp. and Enterocytozoon bieneusi are enteric pathogens that have emerged as significant causes of persistent diarrhea (PD) in immunologically compromised individuals particularly association with HIV/AIDS. We conducted a cross-sectional study on the clinical epidemiology E. children PD, without HIV/AIDS, attending Uganda's Mulago National Referral Hospital. Two hundred forty-three aged < 60 months, admitted between November 2002 May 2003 PD (> 14 days), were analyzed for HIV...
BackgroundSickle cell disease contributes substantially to mortality in children younger than 5 years sub-Saharan Africa. In Uganda, 20 000 babies per year are thought be born with sickle disease, but accurate data not available. We did the cross-sectional Uganda Sickle Surveillance Study assess burden of disease.MethodsThe primary objective study was calculate prevalence trait and disease. obtained punch samples from dried blood spots routinely collected HIV-exposed infants ten regions 112...
Background The objective of the study was to evaluate effect a written invitation letter spouses new antenatal clinic attendees on attendance by couples and male partner acceptance HIV testing at subsequent visits. Methods trial conducted with 1060 from October 2009 February 2010 in an Mbale Regional Referral Hospital, District, eastern Uganda. intervention comprised delivered attendees, while control group received information letter, leaflet, concerning care. primary outcome measure...
Healthy infants typically regain their birth weight by 21 days of age; however, failure to do so may be due medical, nutritional or environmental factors. Globally, the incidence low deliveries is high, but few studies have assessed postnatal changes in this category infants, especially Africa. The aim was determine what proportion LBW had not regained age after discharge from Special Care Unit Mulago hospital, Kampala. A cross sectional study conducted assessing recovery 235 attending...
Our goal was to compare the efficacy and safety of buccal midazolam with rectal diazepam in treatment prolonged seizures Ugandan children.This a single-blind, randomized clinical trial which 330 patients were randomly assigned receive or diazepam. The conducted pediatric emergency unit national referral hospital Uganda. Consecutive who aged 3 months 12 years presented while convulsing experienced seizure that lasted >5 minutes plus placebo placebo. primary outcome this study cessation...
Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide. Children in developing countries die more because several factors including poorer access to hydration therapy and greater prevalence malnutrition. Hitherto, magnitude rotavirus disease Uganda has remained unknown. This study was therefore done determine associated with infection aged 3-59 months admitted acute paediatric emergency ward Mulago Hospital, Three hundred ninety children, between...
Respiratory cryptosporidiosis is recognized as a late-stage complication in persons with human immunodeficiency virus (HIV) infection and AIDS. However, respiratory signs symptoms are common otherwise healthy children intestinal cryptosporidiosis, which suggests that may occur immunocompetent hosts.We recruited 9-36 months of age who presented diarrhea to Mulago Hospital Kampala, Uganda, from November 2007 through January 2009. Children stool samples positive or negative for Cryptosporidium...
The global breastfeeding recommendation states that all infants should be put to the breast within one hour of birth, which is defined as timely initiation or early breastfeeding. Early associated with reduced risk in infant illness and death. Understanding determinants delay might spur health staff policy makers foster We assessed prevalence among mothers Juba Teaching Hospital. present study enrolled 806 mother-infant pairs 24 hrs birth Hospital 2017. were interviewed about time...
Helicobacter pylori is one of the most common causes bacterial infection in human beings. Studies have showed a high prevalence among people low-income countries and colonization early life. A monoclonal antigen test, performed on faeces, HpSA®ImmunoCardSTAT, has sensitivity, specificity accuracy faecal test can be all ages, also resource-limited settings. The main objective this study was to determine factors associated with apparently healthy children aged 0-12 years urban Kampala, Uganda....
Abstract Background Pneumonia is a leading cause of children's deaths in developing countries and hinders achievement the fourth Millennium Development Goal. This goal aims to reduce under-five mortality rate, by two thirds, between 1990 2015. Few studies have examined impact zinc adjunct therapy on outcome childhood pneumonia. We determined effect as time normalization respiratory temperature oxygen saturation. also studied case fatality severe pneumonia (as secondary outcome) Mulago...
Calprotectin is a calcium and zinc binding protein, abundant in neutrophils extremely stable faeces. Faecal calprotectin used as non-specific marker for gastrointestinal inflammation. It has good diagnostic precision to distinguish between irritable bowel syndrome inflammatory disease. Studies have established normal concentrations healthy children; all these studies been performed high-income countries. The objective of this study was determine the concentration faecal apparently children...
BackgroundPneumonia is considered the major cause of mortality among children with acute respiratory disease in low-income countries but may be over-diagnosed at cost under-diagnosing asthma. We report magnitude asthma and pneumonia "under-fives" cough difficulty breathing, based on stringent clinical criteria. also describe treatment for symptoms Mulago Hospital. MethodsWe enrolled 614 aged 2–59 months breathing. Interviews, physical examination, blood radiological investigations were done....
Background Sepsis is the third most common cause of death among neonates, with about 225,000 newborns dying every year globally. Data concerning microbial etiology neonatal sepsis and antimicrobial resistance profiles its causative agents are necessary to inform targeted effective treatment prevention strategies. Objective To determine proportion symptoms signs who had a positive blood culture, bacterial etiology, patterns as well factors associated culture-positivity case fatality at Mulago...
Background The delivery of HIV counselling and testing services for children remains an uphill task many health workers in HIV‐endemic countries, including Uganda. We conducted a descriptive study to explore the challenges providing Methods A was districts Kampala Kabarole data were collected using semi‐structured individual interviews focus group discussions with who are involved care HIV‐positive children. Key informant administrators 10 healthcare institutions. Quantitative summarized...
Background HIV testing rates have exceeded 90% among the pregnant women at Mbale Regional Referral Hospital in District, eastern Uganda, since introduction of routine antenatal counselling and for June 2006. However, no documented information was available about opinions Uganda this approach. We therefore conducted a study to assess attitudes attendees towards Hospital. also assessed their knowledge mother child transmission infant feeding options HIV‐infected mothers. Methods The...
Early recognition of antiretroviral therapy (ART) failure in resource limited settings is a challenge given the laboratory facilities and trained personnel. This study aimed at describing incidence, risk factors resistance associated mutations (RAMs) first line treatment among HIV-1-infected children attending Joint Clinical Research Centre (JCRC), Kampala, Uganda.A retrospective cohort 701 who had been initiated on ART between January 2004 September 2009 JCRC was studied. Data aged 6 months...
We studied associations between delayed care seeking, demographic, socioeconomic, and geographic factors likelihood of severe malaria in Ugandan children. The study was based at Jinja Hospital, Uganda. enrolled 325 cases uncomplicated controls matched by age residence. Patient details, an itinerary events response to illness, household information, location participants' residences were captured. Conditional logistic regression used determine risk for seeking. Delayed seeking (≥ 24 hours...
Initiation of breastfeeding later than 1 hour after birth is associated with increased neonatal morbidity and mortality.To determine the prevalence factors delayed initiation breastfeeding.We conducted a survey in 2016 930 children under age 2 years Lira district, northern Uganda. Mothers were interviewed data was collected on mobile phones using Open Data Kit software ( https://opendatakit.org ). Multivariable logistic regression used to breastfeeding.Almost half [48.2%, 95% confidence...
Background: Perinatal mortality in Uganda remains high at 38 deaths/1,000 births, an estimate greater than the every newborn action plan (ENAP) target of ≤24/1,000 births by 2030. To improve perinatal survival, there is a need to understand persisting risk factors for death.Objective: We determined incidence, factors, and causes death Lira district, Northern Uganda.Methods: This was community-based prospective cohort study among pregnant women Uganda. Female community volunteers identified...
Background Timely initiation of and exclusive breastfeeding have been recommended as key interventions to enable countries attain the sustainable development target reducing neonatal mortality no more than 12 deaths per 1000 live births reduce children under 5 years 25 births. Methods We conducted a cluster randomized controlled trial with main objective assess effect an integrated package consisting of: peer counseling, mobile phone messages, mama kits on promoting health facility between...
Hepatitis B is a major global health concern, with chronic infections affecting approximately 296 million people yearly. A 2009 survey in East Africa showed prevalence rate of 6.5%, Uganda's at 10.3% and Northern Uganda 20.7%. Therefore, this study sought to determine the immune response vaccination associated factors among children under five attending outpatient care Mulago Assessment Centre Pediatrics clinic. cross-sectional involving 301 aged 1 5 years National Referral's clinic was...