A5067055005- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Adolescent and Pediatric Healthcare
- Syphilis Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Pneumocystis jirovecii pneumonia detection and treatment
National HIV/AIDS/STI/TB Council
2021-2023
Stellenbosch University
2021
Testing men for HIV during their partner's pregnancy can guide couples-based prevention and treatment, but testing rates remain low. We investigated a combination approach, using evidence-based strategies, to increase in male partners of HIV-positive HIV-negative pregnant women.We did two parallel, unmasked randomised trials, enrolling women who had an test result documented antenatal record (trial 1) 2) from setting Lusaka, Zambia. Women both trials were randomly assigned (1:1) the...
Point-of-care (POC) early infant diagnosis (EID) provides same-day results and the potential for immediate initiation of antiretroviral therapy (ART).
<sec> <title>UNSTRUCTURED</title> Background: Zambia has one of the highest rates prevalence HIV among adolescents and young adults living with (AYAHIV) in sub-Saharan Africa, who, as 2023, represent half all new cases annually. Compared to their peers who are negative, AYAHIV at an increased risk developing cancer. The most frequently diagnosed cancers cervical cancer (CC), Kaposi Sarcoma (KS), non-Hodgkin’s Lymphoma (NHL). Premature mortality is driven by late-stage presentation poor...
Background To meet global targets for the elimination of mother-to-child HIV transmission, tailored approaches to testing strategies need prioritizing. Herein, we sought identify individual-level factors associated with male partner testing. Methods We conducted a secondary analysis data from two parallel randomized trials pregnant women living and those HIV-negative in Lusaka, Zambia. Across both trials, control groups received notification services only, while intervention plus self-test...
Background: Early infant diagnosis (EID) of HIV is critical to the care 1.3 million infants who are perinatally exposed virus each year. Point-of-care (POC) EID provides same-day results and potential for improved survival through immediate initiation antiretroviral therapy (ART).Methods: We conducted a pragmatic randomised trial at 6 primary health centres in Lusaka, Zambia. HIV-exposed were equally allocated either: (a) POC – on-site testing with Alere q HIV-1/2 Detect instrument or (b)...
This study explored the experiences of pregnant women who received two intervention models for increasing uptake male partner HIV testing in antenatal settings. As part a randomised trial, we interviewed twenty participants notification services only while 22 plus self-testing. Thematic analysis was used to analyse data. Partner helped initiate discussions with partners, influence partners undergo testing, and encouraged disclosure status. Some experienced difficulties engaging due fear...
Mothers living with human immunodeficiency virus (HIV) should be guided to practise safe childbirth, provide appropriate infant feeding, return infants for repeat HIV testing and administer the required period, protective antiretroviral (ARV) medication (post-exposure prophylaxis [PEP]) their infants. Although several studies have explored challenges related prevention of mother-to-child transmission (PMTCT), no were found that focused specifically on mother PEP.To explore understand...