A5078764165- IL-33, ST2, and ILC Pathways
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Pediatric health and respiratory diseases
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Digestive system and related health
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Autophagy in Disease and Therapy
- Inflammatory mediators and NSAID effects
- Allergic Rhinitis and Sensitization
- Bone and Dental Protein Studies
- Parkinson's Disease Mechanisms and Treatments
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
Institut Pasteur
2024-2025
Centre National de la Recherche Scientifique
2024-2025
Immunité et Cancer
2025
Biomedical Research Foundation of the Academy of Athens
2015-2024
Academy of Athens
2011-2024
University of Crete
2009-2024
Foundation for Research and Technology Hellas
2023-2024
University of Gothenburg
2010
Institute of Bioorganic Chemistry
2009
Philipps University of Marburg
2009
Abstract Approximately 90% of alpha-synuclein (α-Synuclein) deposited in Lewy bodies is phosphorylated at serine 129 suggesting that the accumulation α-Synuclein critical pathogenesis Parkinson’s disease. However, vivo experiments addressing role progression disease have produced equivocal data. To clarify a Ser129 phosphorylation pathology we performed stereotaxic injections targeting mouse striatum with three fibrilar types: wt-fibrils, S129 fibrils and, incompetent, S129A fibrils. Brain...
Abstract Background It is now realized that Parkinson’s disease (PD) pathology extends beyond the substantia nigra, affecting both central and peripheral nervous systems, exhibits a variety of non-motor symptoms often preceding motor features. Neuroinflammation induced by activated microglia astrocytes thought to underlie these manifestations. α-Synuclein aggregation has been linked with sustained neuroinflammation in PD, aggravating neuronal degeneration; however, there still lack critical...
Activin-A is a pleiotropic cytokine that participates in developmental, inflammatory, and tissue repair processes. Still, its effects on T helper (Th) cell–mediated immunity, critical for allergic autoimmune diseases, are elusive. We provide evidence endogenously produced activin-A suppresses antigen-specific Th2 responses protects against airway hyperresponsiveness disease mice. Importantly, we reveal exerts suppressive function through induction of regulatory cells suppress vitro upon...
Recent studies have associated osteopontin (OPN) with allergic inflammation; however, its role in human asthma remains unclear. The aim of this study was to measure OPN levels the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue healthy controls asthmatics, identify cellular sources examine possible correlations between expression, disease severity airway remodelling. Serum samples were obtained from 35 mild-to-moderate 19 severe asthmatics 17 steady state cases exacerbation....
Little is known about what drives the appearance of lymphoid follicles (LFs), which may function as organs in chronic obstructive pulmonary disease (COPD). In animal infection models, LF formation requires expression homeostatic chemokines by stromal cells and dendritic cells, partly via lymphotoxin.To study role COPD to identify mechanism(s) responsible for their production.Peripheral lung chemokine lymphotoxin were visualized immunostainings quantified ELISA/quantitative reverse...
Abstract Background NLRP3‐driven inflammatory responses by circulating and lung‐resident monocytes are critical drivers of asthma pathogenesis. Autophagy restrains NLRP3‐induced monocyte activation in models. Yet, the effects autophagy its master regulator, transcription factor EB (TFEB), on human remain unexplored. Here, we investigated whether TFEB signaling suppress asthmatic individuals. Methods Peripheral blood CD14 + from patients ( n = 83) healthy controls 46) were stimulated with...
Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental allergens and protecting against allergic diseases. Still, the precise molecular cues that underlie their transcriptional functional specification remain elusive. Here, we show cytokine activin-A instructs generation of CD4 + express Tr1-cell–associated molecules IL-10, inducible T-Cell costimulator (ICOS), lymphocyte activation gene 3 protein (LAG-3), CD49b, exert strongly...
Activin-A is a pleiotropic cytokine that regulates allergic inflammation. Its role in the regulation of angiogenesis, key feature airways remodelling asthma, remains unexplored. Our objective was to investigate expression activin-A asthma and its effects on angiogenesis vitro . Expression soluble/immunoreactive receptors measured serum, bronchoalveolar lavage fluid (BALF) endobronchial biopsies from 16 healthy controls, 19 patients with mild/moderate 22 severely asthmatic patients. In...
In multiple sclerosis (MS), Th17 cells are critical drivers of autoimmune central nervous system (CNS) inflammation and demyelination. exhibit functional heterogeneity fostering both pathogenic nonpathogenic, tissue-protective functions. Still, the factors that control pathogenicity remain incompletely defined. Here, using experimental encephalomyelitis, an established mouse MS model, we report therapeutic administration activin-A ameliorates disease severity alleviates CNS immunopathology...
Pioneering studies on tumor and immune cell interactions have highlighted checkpoint inhibitors (ICIs) as revolutionizing interventions for the management of NSCLC, typically combined with traditional MTD chemotherapies, which usually lead to toxicities resistance treatment. Alternatively, MTR chemotherapy is based daily low dose administration chemotherapeutics, preventing growth indirectly by targeting microenvironment. The effects an oral prodrug gemcitabine (OralGem), alone or anti-PD1,...
Upon allergen challenge, DC subsets are recruited to target sites under the influence of chemotactic agents; however, details pertinent their trafficking remain largely unknown. We investigated kinetic profiles blood and skin-infiltrating in twelve atopic subjects receiving six weekly intradermal diluent injections. The role activin-A, a cytokine induced allergic tissue repair processes, on was also examined. Plasmacytoid (pDCs) conventional DCs (cDCs) were evaluated at various time-points...
Background B cells, key cells in allergic inflammation, differentiate the bone marrow and their precursors include pro-B, pre-B immature cells. Eosinophil progenitor increase lung after allergen exposure. However, existence possible role of cell during inflammation remains elusive. Methods A BALB/c mouse model airway was utilized to perform phenotypic quantification analyses pro-B by flow cytometry. maturation factors IL-7 cell-activating factor (BAFF) receptors (CD127 BAFFR, BCMA, TACI,...
Abatacept (CTLA4-Ig)—a monoclonal antibody which restricts T cell activation—is an effective treatment for rheumatoid arthritis (RA). Nevertheless, only 50% of RA patients attain clinical responses, while predictors response are rather limited. Herein, we aimed to investigate early biomarkers abatacept, based on a detailed immunological profiling peripheral blood (PB) cells and serum proteins. We applied flow cytometry proteomics analysis PB immune respectively, starting abatacept as the...
Background: Chronic obstructive pulmonary disease (COPD) is a common characterized by progressive airflow obstruction, influenced genetic and environmental factors. Eosinophils have been implicated in COPD pathogenesis, prompting the categorization into eosinophilic non-eosinophilic endotypes. This study explores association between inflammation mRNA expression of ELAVL1, ZfP36, HNRNPD genes, which encode HuR, TTP AUF-1 proteins, respectively. Additionally, it investigates IL-9 IL-33...