A5002935623- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Infant Nutrition and Health
- Cytokine Signaling Pathways and Interactions
- Digestive system and related health
- Bone and Dental Protein Studies
- IL-33, ST2, and ILC Pathways
- Cutaneous lymphoproliferative disorders research
- Reproductive System and Pregnancy
- Nail Diseases and Treatments
- Fungal Infections and Studies
- TGF-β signaling in diseases
- Immune Response and Inflammation
- Neutropenia and Cancer Infections
- Contact Dermatitis and Allergies
- Phagocytosis and Immune Regulation
- Biomarkers in Disease Mechanisms
- Cell Adhesion Molecules Research
- Blood disorders and treatments
Academy of Athens
2014-2024
Biomedical Research Foundation of the Academy of Athens
2009-2022
Institute of Bioorganic Chemistry
2009
Philipps University of Marburg
2009
Aichi Gakuin University
2009
Medical University of Vienna
2009
Hospital Universitario La Paz
2009
University of Tübingen
2009
Activin-A is a pleiotropic cytokine that participates in developmental, inflammatory, and tissue repair processes. Still, its effects on T helper (Th) cell–mediated immunity, critical for allergic autoimmune diseases, are elusive. We provide evidence endogenously produced activin-A suppresses antigen-specific Th2 responses protects against airway hyperresponsiveness disease mice. Importantly, we reveal exerts suppressive function through induction of regulatory cells suppress vitro upon...
Intestinal CD103(-) dendritic cells (DCs) are pathogenic for colitis. Unveiling molecular mechanisms that render these proinflammatory is important the design of specific immunotherapies. In this report, we demonstrated mesenteric lymph node DCs express, among other cytokines, high levels osteopontin (Opn) during experimental Opn expression by was crucial their immune profile and pathogenicity, including induction T helper (Th) 1 Th17 cell responses. Adoptive transfer Opn-deficient resulted...
Abstract T cell Ig and ITIM domain receptor (TIGIT), expressed on T, NK, regulatory cells, is known as an inhibitory molecule that limits autoimmunity, antiviral antitumor immunity. In this report, we demonstrate TIGIT enhances Th2 expression was upregulated in activated cells from mice with experimental allergic disease polarization cultures. addition, its high-affinity ligand CD155 mediastinal lymph node dendritic mice. vitro setting, observed Tigit interaction were important during the...
Abstract Multiple sclerosis (MS), an autoimmune disease of the CNS, is mediated by autoreactive Th cells. A previous study showed that neurosteroid dehydroepiandrosterone (DHEA), when administered preclinically, could suppress progression relapsing-remitting experimental encephalomyelitis (EAE). However, effects DHEA on human or murine pathogenic immune cells, such as Th17, were unknown. In addition, this symptomatic disease, well receptors involved, had not been investigated. study, we show...
Abstract The development of therapies for multiple sclerosis targeting pathogenic T cell responses remains imperative. Previous studies have shown that estrogen receptor (ER) β ligands could inhibit experimental autoimmune encephalomyelitis. However, the effects ERβ-specific on human or murine immune cells, such as Th17, were not investigated. In this article, we show synthetic ligand 4-(2-phenyl-5,7-bis[trifluoromethyl]pyrazolo[1,5-a]pyrimidin-3-yl)phenol (PHTPP) reversed established...
Type I interferon (IFN) production by plasmacytoid dendritic cells (pDCs) has been mainly studied in the context of Toll-like receptor (TLR) activation. In current report, we reveal that, absence TLR activation, integrin-binding SLAYGLR motif secreted osteopontin (sOpn) induces IFN-β murine pDCs. This process is mediated α4β1 integrin, indicating that integrin triggering may act as a subtle danger signal leading to induction. The SLAYGLR-mediated α4 integrin/IFN-β axis MyD88 independent and...
Abstract In the context of inflammation, osteopontin (Opn) is known to promote effector responses, facilitating a proinflammatory environment; however, its role during antigenic tolerance induction unknown. Using mouse model asthma, we investigated Opn and effects on associated regulatory cellular populations prior disease initiation. Our experiments demonstrate that drives protective by inducing accumulation IFN-β–producing plasmacytoid dendritic cells, as well T in mediastinal lymph nodes....
Foxp3-expressing regulatory T (Treg) cells represent the most highly immunosuppressive cell in tumor microenvironment (TME) that halts effective anti-tumor immunity. Osteopontin (Opn), an extracellular matrix (ECM) glycophosphoprotein, plays key roles many types of immune-related diseases and is associated with cancer aggressiveness when expressed by cells. However, its role Foxp3Treg heterogeneity, function, stability TME poorly defined. We generated mice a Foxp3-specific deletion Opn...
Abstract No Abtract