A5084264392- Multiple Sclerosis Research Studies
- Cerebral Palsy and Movement Disorders
- Autoimmune and Inflammatory Disorders Research
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Advanced Radiotherapy Techniques
- Effects of Vibration on Health
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Stroke Rehabilitation and Recovery
- Fungal Infections and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Bacterial Identification and Susceptibility Testing
- Head and Neck Cancer Studies
- Antibiotics Pharmacokinetics and Efficacy
- Medical Imaging Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Musculoskeletal Disorders and Rehabilitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Vector-borne infectious diseases
- Herpesvirus Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Chemical Reaction Mechanisms
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
Glasgow Caledonian University
2011-2024
Ayrshire Central Hospital
2007-2022
NHS Ayrshire and Arran
2008-2020
GlaxoSmithKline (United States)
2016-2017
University of Glasgow
2017
Isle of Wight NHS Trust
2016
St. Mary’s Hospital
2016
University of East Anglia
2014
Physiotherapy New Zealand
2005-2014
Allegheny General Hospital
2006-2010
The aim of the study was to establish test–retest reliability, clinical significance and precision four mobility balance measures – Timed 25-Foot Walk, Six-minute Up Go Berg Balance Scale in individuals moderately affected by multiple sclerosis. Twenty participants with sclerosis (Extended Disability Status Score 5–6.5) were assessed on balance. Walk outcome one assessor week apart. Intraclass correlation coefficient (ICC) analysis carried out determine reliability. Minimal detectable change...
To establish the effects of a 12-week, community-based group exercise intervention for people moderately affected with multiple sclerosis.Randomized controlled pilot trial.Two community leisure centres.Thirty-two participants sclerosis randomized into or control groups.The received 12 weeks twice weekly, 60-minute sessions, including mobility, balance and resistance exercises. The usual care.An assessor blinded to allocation assessed at baseline, after eight weeks. primary outcome measure...
To explore the effectiveness and participant experience of web-based physiotherapy for people moderately affected with Multiple Sclerosis (MS) to provide data establish sample size required a fully powered, definitive randomized controlled study.A pilot study.Rehabilitation centre participants' homes.Thirty community dwelling adults by MS (Expanded Disability Status Scale 5-6.5).Twelve weeks individualised completed twice per week or usual care (control). Online exercise diaries were...
Spasticity is a common and often disabling symptom associated with multiple sclerosis (MS). Transcutaneous electrical nerve stimulation (TENS) has been found effective in reducing spasticity conditions such as stroke, but there little evidence to support its use MS. The aim of this study was evaluate the effectiveness TENS on MS and, furthermore, compare two different application times. Thirty-two subjects were randomized into groups, single, blind, crossover design used weeks 60 minutes 8...
Functional electrical stimulation (FES) is used clinically in the management of drop foot people suffering from neurological conditions. The aim study was to investigate effects FES, terms speed and physiological cost gait, with multiple sclerosis (pwMS).Twelve pwMS 12 healthy matched controls walked at their own preferred walking (PWS) for 5 min around a 10 m elliptical course. Subjects MS completed protocol without using FES. In addition, control subjects twice more same PWS which they...
Objective: To examine the feasibility of a trial to evaluate web-based physiotherapy compared standard home exercise programme in people with multiple sclerosis. Design: Multi-centre, randomized controlled, study. Setting: Three sclerosis out-patient centres. Participants: A total 90 (Expanded Disability Status Scale 4–6.5). Interventions: Participants were six-month individualized, delivered via ( n = 45; intervention) or sheet exercises active comparator). Outcome measures: measures (0,...
The evidence base to support therapeutic exercise for people with multiple sclerosis (MS) is improving; however few studies have considered the patients' perspective. This study aimed explore experiences and views of moderately affected MS following participation in a 12-week programme.Twenty participated group class. Subsequently, four men ten women took part one two focus groups. Semi-structured questions were used elicit participants' on class, outcomes from class any perceived...
Objective:To compare the clinical- and cost-effectiveness of ankle-foot orthoses (AFOs) functional electrical stimulation (FES) over 12 months in people with Multiple Sclerosis foot drop. Subjects:Eighty-five treatment-naïve persistent (>three months) Outcome measures:Assessed at 0, 3, 6 months; 5-minute self-selected walk test (primary), Timed 25 Foot Walk, oxygen cost walking, Impact Scale-29, Walking Scale-12, Modified Fatigue Scale, Euroqol five-dimension five-level questionnaire,...
Objective: To investigate the effect of an eight-week home-based physiotherapy programme in reducing physical impairment, disability and psychological distress for people with moderate to severe multiple sclerosis (MS). Design: Pilot randomized controlled trial. Setting: Community; subjects’ homes. Subjects: Thirty moderately severely affected by MS (Extended Disability Status Score, EDSS, 6.5–8) were intervention or control group. Intervention: The group received twice weekly, eight weeks...
Functional electrical stimulation (FES), an assistive device used for foot drop, has been found to improve the speed and energy cost of walking in people with multiple sclerosis (pwMS). This study aims compare immediate orthotic effect on two different devices; Odstock Dropped Foot Stimulator (ODFS) Walkaide (WA).Twenty pwMS (10 female, 10 male, mean age 50.4 ± 7.3 years) currently using ODFS were recruited. Participants walked 5 min around elliptical 9.5 m course at their preferred speed;...
Functional electrical stimulation (FES) is effective in assisting people with multiple sclerosis (pwMS) gait. Previous studies have investigated the effects of FES pwMS slow self-selected walking speeds (SSWS). This study reports on effect Odstock Dropped Foot Stimulator (ODFS) speed and oxygen (O2) cost gait at a range SSWS.Twenty (mean age 50.4 ± 7.3 years) currently using walked their SSWS for 5 min without FES. O2 was measured gas analysis system, calculated. Data were analysed all...
Objective: To examine the feasibility of delivering reflexology to people moderately severely affected by multiple sclerosis and investigate effect on a range symptoms. Methods: A pilot single-blind randomized placebo controlled trial. Setting: An outpatient rehabilitation centre. Subjects: Twenty were into one two groups receiving either or sham reflexology. Intervention: Each participant received 8 weeks, 1 hour per week Main measures: Primary outcome measure was Multiple Sclerosis Impact...
This pilot study was conducted to determine whether a 15-minute bout of moderate-intensity aerobic cycling exercise would affect symptoms (pain and fatigue) function (Timed 25-Foot Walk test [T25FW] Timed Up Go [TUG]) in people with multiple sclerosis (MS) or chronic fatigue syndrome (CFS), compare these results those healthy control group.Eight MS (Expanded Disability Status Scale score 5-6; Karnofsky 50-80), eight CFS (Karnofsky volunteers participated the study. Pain levels T25FW TUG were...
Foot drop affects walking in people with multiple sclerosis (pwMS). This study compares the initial orthotic effects of two treatments for foot drop: ankle-foot orthoses (AFO) and functional electrical stimulation (FES), on speed oxygen cost MS.Seventy-eight pwMS were randomised to receive AFO or FES (ODFS PACE (OML, Salisbury, UK)). Participants completed 25-ft walk test (25ftWT) 5-min self-selected (5minSSWT), from which was determined, without their device. Between-, within- sub-group...
Background Balance, mobility impairments and falls are common problems for people with multiple sclerosis (MS). Our ongoing research has led to the development of Balance Right in MS (BRiMS), a 13-week home- group-based exercise education programme intended improve balance encourage safer mobility. Objective This feasibility trial aimed obtain necessary data operational experience finalise planning future definitive multicentre randomised controlled trial. Design Randomised Participants were...
To explore the feasibility of conducting a Phase III randomized controlled trial evaluating sensory dynamic orthoses for upper limb tremor in multiple sclerosis.Mixed methods: double blind placebo pilot study and semi-structured interviews.Rehabilitation centre.A total 21 people with sclerosis tremor.Participants received orthosis sleeve or non-compressive (placebo) that they wore eight hours day, nine weeks.Outcomes were completed at baseline weeks. The primary outcome measure was...
The dependence of growth rates Escherichia coli on sulfonamides or trimethoprim (TMP) has been established. new steady state is obtained shortly after addition TMP, whereas a lag phase about five generations observed for sulfonamides. inhibitory effect TMP times larger than the sulfamethoxazole (SMZ) as evaluated from plot 1/ko–kapp vs. 1/C. well that reversible if drug containing culture diluted. Whereas sulfonamide only bacteriostatic, can cause bacterial death certain threshold...