A5002415902- Health Systems, Economic Evaluations, Quality of Life
- Pelvic floor disorders treatments
- Delphi Technique in Research
- Health Policy Implementation Science
- Substance Abuse Treatment and Outcomes
- Obesity, Physical Activity, Diet
- Clinical practice guidelines implementation
- Primary Care and Health Outcomes
- Homelessness and Social Issues
- Family and Disability Support Research
- Dysphagia Assessment and Management
- Healthcare Policy and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Geriatric Care and Nursing Homes
- Child Nutrition and Feeding Issues
- Health disparities and outcomes
- Injury Epidemiology and Prevention
- Behavioral Health and Interventions
- Family and Patient Care in Intensive Care Units
- Muscle Physiology and Disorders
- Patient Satisfaction in Healthcare
- Dental Health and Care Utilization
- Obesity and Health Practices
- Palliative Care and End-of-Life Issues
- Acute Ischemic Stroke Management
Newcastle University
2016-2025
University of East Anglia
2024
Norwich Research Park
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020-2023
Great North Children's Hospital
2014-2023
Royal Victoria Infirmary
2014-2023
Great Ormond Street Hospital
2020-2023
University College London
2020-2023
Robert Jones and Agnes Hunt Orthopaedic Hospital
2021
University of Rochester
2021
BackgroundWhole brain radiotherapy (WBRT) and dexamethasone are widely used to treat metastases from non-small cell lung cancer (NSCLC), although there have been no randomised clinical trials showing that WBRT improves either quality of life or overall survival. Even after treatment with WBRT, the prognosis this patient group is poor. We aimed establish whether could be omitted without a significant effect on survival life.MethodsThe Quality Life Treatment for Brain Metastases (QUARTZ) study...
Objectives To assess the safety of intra-articular (IA) autologous tolerogenic dendritic cells (tolDC) in patients with inflammatory arthritis and an inflamed knee; to feasibility acceptability approach potential effects on local systemic disease activities. Methods An unblinded, randomised, controlled, dose escalation Phase I trial. TolDC were differentiated from CD14+ monocytes loaded synovial fluid as a source autoantigens. Cohorts three participants received 1×10 6 , 3×10 or 10×10 tolDC...
Successful implementation and embedding of new health care practices relies on co-ordinated, collective behaviour individuals working within the constraints settings. Normalization Process Theory (NPT) provides a theory that emphasises action in explaining, shaping, practices. To extend practical utility NPT for improving success, an instrument (NoMAD) was developed validated.Descriptive analysis psychometric testing by authors, through iterative process included item generation, consensus...
Corticosteroids improve strength and function in boys with Duchenne muscular dystrophy. However, there is uncertainty regarding the optimum regimen dosage.To compare efficacy adverse effects of 3 most frequently prescribed corticosteroid regimens dystrophy.Double-blind, parallel-group randomized clinical trial including 196 aged 4 to 7 years dystrophy who had not previously been treated corticosteroids; enrollment occurred between January 30, 2013, September 17, 2016, at 32 clinic sites 5...
OBJECTIVES--To test the validity and reliability of scales for measuring patients9 experiences satisfaction with nursing care; to ability detect differences between hospitals wards; investigate whether place completion, hospital, or home influences response. DESIGN--Sample survey. SETTING--20 wards in five north east England. PATIENTS--2078 patients general medical surgical wards. MAIN MEASURES-- Experiences care. RESULTS--75% approached complete questionnaires did so. Construct internal...
Understanding implementation processes is key to ensuring that complex interventions in healthcare are taken up practice and thus maximize intended benefits for service provision (ultimately) care patients. Normalization Process Theory (NPT) provides a framework understanding how new intervention becomes part of normal practice. This study aims develop validate simple generic tools derived from NPT, be used improve the interventions. The objectives this to: set NPT-based measures formatively...
Background Falls cause fear, anxiety and loss of confidence, resulting in activity avoidance, social isolation increasing frailty. The umbrella term for these problems is ‘fear falling’, seen up to 85% older adults who fall. Evidence effectiveness physical psychological interventions limited, with no previous studies examining the role an individually delivered cognitive–behavioural therapy (CBT) approach. Objectives Primary objective To develop then determine a new CBT intervention (CBTi)...
Understanding and measuring implementation processes is a key challenge for researchers. This study draws on Normalization Process Theory (NPT) to develop an instrument that can be applied assess, monitor or measure factors likely affect normalization from the perspective of participants.An iterative process development was undertaken using following methods: theoretical elaboration, item generation reduction (team workshops); appraisal (QAS-99); cognitive testing with complex intervention...
Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo perfusion (EVLP) allows initially unusable lungs to be assessed and reconditioned for clinical use.The objective of the Donor Vivo Lung Perfusion in UK study was evaluate effectiveness cost-effectiveness EVLP increasing transplant activity.A multicentre, unblinded, non-randomised, non-inferiority observational compare outcomes between EVLP-assessed standard lungs.Multicentre involving all five...
Head and neck cancer squamous cell carcinoma (HNSSC) patients report substantial rates of clinically significant depression and/or anxiety, with dysphagia being a predictor distress poorer quality life. Evidence-based interventions largely focus on the remediation physical impairment. This feasibility study evaluates an intervention which simultaneously uses psychological therapy approach combined swallowing impairment rehabilitation. prospective single cohort mixed-methods study, recruited...
Intraparenchymal hemorrhages occur in a proportion of severe traumatic brain injury TBI patients, but the role surgery their treatment is unclear. This international multi-center, patient-randomized, parallel-group trial compared early (hematoma evacuation within 12 h randomization) with initial conservative (subsequent allowed if deemed necessary). Patients were randomized using an independent randomization service 48 TBI. eligible they had no more than two intraparenchymal 10 mL or and did...
In 2004, a Cochrane Review and AAN practice parameter concluded that prednisone 0.75 mg/kg/day is of short-term efficacy in Duchenne muscular dystrophy (DMD). Subsequent efforts to standardize care for DMD indicated wide variation corticosteroid use.We surveyed physicians who follow patients with DMD, including: (1) clinics the TREAT-NMD (Translational Research Europe-Assessment Treatment Neuromuscular Diseases) network (predominantly Europe) (2) U.S. MDA clinic directors. We also documented...
Repeated symptomatic urinary tract infections (UTIs) affect 25% of people who use clean intermittent self-catheterisation (CISC) to empty their bladder. We aimed determine the benefits, harms, and cost-effectiveness continuous low-dose antibiotic prophylaxis for prevention recurrent UTIs in adult users CISC.
We conducted a randomized exploratory study to assess safety and the probability of favorable outcome with adjunctive argatroban, direct thrombin-inhibitor, administered recombinant tissue-type plasminogen activator (r-tPA)-treated ischemic stroke patients.Patients treated standard-dose r-tPA, not receiving endovascular therapy, were receive no argatroban or (100 μg/kg bolus) followed by infusion either 1 (low dose) 3 per minute (high for 48 hours. Safety was incidence symptomatic...
BackgroundEstablishing predictors of quality life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely experience poor QoL and target therapeutic interventions appropriately. We aimed investigate how disease-specific depends on demographic, diseaserelated, physiological markers activity, cognitive representations illness, perceived general health status.