A5083082200- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Legionella and Acanthamoeba research
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Long-Term Effects of COVID-19
- Biosensors and Analytical Detection
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Bacterial biofilms and quorum sensing
- Coronary Artery Anomalies
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cancer survivorship and care
- Radiation Therapy and Dosimetry
Cardiff University
2023-2024
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
Public Health Scotland
2021
University Hospitals Birmingham NHS Foundation Trust
2021
Public Health England
2021
Oxford University Clinical Research Unit
2021
BackgroundWhole brain radiotherapy (WBRT) and dexamethasone are widely used to treat metastases from non-small cell lung cancer (NSCLC), although there have been no randomised clinical trials showing that WBRT improves either quality of life or overall survival. Even after treatment with WBRT, the prognosis this patient group is poor. We aimed establish whether could be omitted without a significant effect on survival life.MethodsThe Quality Life Treatment for Brain Metastases (QUARTZ) study...
About 90 % of patients with intra-thoracic malignancy experience breathlessness. Breathing training is helpful, but it unknown whether repeated sessions are needed. The present study aims to test three better than one for breathlessness in this population. This a multi-centre randomised controlled non-blinded parallel arm trial. Participants were allocated or single (1:2 ratio) using central computer-generated block randomisation by an independent Trials Unit and stratified centre. setting...
Abstract Backgroud Although not fully investigated, studies show that Legionella pneumophila can develop antibiotic resistance. As there is limited data available for Portugal, we determined the susceptibility profile of Portuguese L. serogroup 1 (LpnSg1) isolates against antibiotics used in clinical practice Portugal. Methods Minimum inhibitory concentrations (MICs) were LpnSg1 ( n = 100) and related environmental 7) isolates, collected between 2006–2022 context National Legionnaire´s...
8005 Background: Brain metastases affect up to 40% of patients with non-small cell lung cancer (NSCLC), and for inoperable cases whole brain radiotherapy (WBRT) dexamethasone is standard treatment. However there are no randomised clinical trials show whether WBRT improves either QoL or survival. Methods: A phase III non-inferiority trial a primary outcome measure quality adjusted life years (QALYs). Patients from NSCLC (not suitable resection stereotactic radiotherapy) were randomly...
54 Background: About 90% of patients with lung cancer experience dyspnea. Breathing training is helpful, but multiple sessions may be onerous. Methods: UK multisite phase 3 RCT, comparing three weekly breathing to a single session for refractory dyspnea due intrathoracic cancer. Primary outcome: self-report “worst” dyspnea/24 hours, (0–10 numerical rating scale [NRS], 0=none; 10=worst imaginable). Secondary outcomes: “average”, distress (NRS); quality life (QoL) (CRQ-SAS; EQ-5D); health...