James Manifield

ORCID: 0000-0002-5859-3772
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Research Areas
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Respiratory Support and Mechanisms
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Cardiovascular and exercise physiology
  • Heart Rate Variability and Autonomic Control
  • Cardiac Health and Mental Health
  • Long-Term Effects of COVID-19
  • Chronic Disease Management Strategies
  • Physical Activity and Health
  • Cardiac Arrest and Resuscitation
  • Public Health and Nutrition
  • Dysphagia Assessment and Management
  • Obstructive Sleep Apnea Research
  • Sarcoidosis and Beryllium Toxicity Research
  • Health, psychology, and well-being
  • Stroke Rehabilitation and Recovery
  • Non-Invasive Vital Sign Monitoring
  • Respiratory viral infections research
  • Health and Well-being Studies
  • Nutrition and Health in Aging
  • Transplantation: Methods and Outcomes

NIHR Leicester Biomedical Research Centre
2023-2025

University of Leicester
2024-2025

Northumbria University
2019-2024

University Hospitals of Leicester NHS Trust
2023-2024

<b>In response to #COVID19, healthcare professionals should scale up virtual consultations for assessing core patient-reported outcomes and providing home-based rehabilitation programmes #COPD</b>https://bit.ly/30gQEpG

10.1183/20734735.0231-2020 article EN Breathe 2020-09-01

We investigated the effect of inspiratory muscle training (IMT) on strength, functional capacity and respiratory kinematics during exercise in healthy older adults.

10.1016/j.resp.2024.104278 article EN cc-by Respiratory Physiology & Neurobiology 2024-05-10

Objectives Pulmonary Rehabilitation (PR) is a high-impact intervention for individuals with idiopathic pulmonary fibrosis (IPF) but access limited in India. PR barriers include distance to travel, lack of service provision and healthcare professionals deliver PR, thus it disproportionate the immense burden IPF We explored lived experiences people living IPF, family caregivers (CGs) workers (HCWs) as well their views towards home-based (HBPR) Delhi, Methods A qualitative study using...

10.1177/14799731241258216 article EN cc-by-nc Chronic Respiratory Disease 2024-01-01

<b>Introduction:</b> Novel pulmonary rehabilitation (PR) models have led to innovations and adjuncts in PR components which may lead differential responses physical activity (PA). <b>Aim:</b> To examine the relative effectiveness of different PR-based interventions on PA. <b>Methods:</b> Randomised trials chronic respiratory disease populations, where at least one intervention arm performed some form PR, were systematically searched for three electronic databases. Network meta-analyses...

10.1183/13993003.congress-2023.oa3260 article EN 01.02 - Rehabilitation and chronic care 2023-09-09

We previously showed that use of portable noninvasive ventilation (pNIV) during recovery periods within intermittent exercise improved breathlessness and tolerance in patients with COPD compared pursed-lip breathing (PLB). However, a minority from dynamic hyperinflation (DH) was better PLB, based on inspiratory capacity. further explored this using Optoelectronic Plethysmography to assess total compartmental thoracoabdominal volumes. Fourteen (means ± SD) (FEV1: 55% 22% predicted) underwent,...

10.1152/japplphysiol.00081.2021 article EN cc-by Journal of Applied Physiology 2021-06-10

<h3>Introduction</h3> To prevent infection during the peak of COVID-19 pandemic, COPD patients were instructed to 'shield', resulting in restrictions usual daily activities, potentially negating health benefits attained pulmonary rehabilitation (PR). The aim this study was determine impact a shielding period on physical activity levels and health-related quality life (HRQoL) who completed course supervised PR before March 2020. <h3>Methods</h3> an 8-week between January 2020 enrolled into...

10.1136/thorax-2020-btsabstracts.383 article EN other-oa 2021-01-21

<b>Background:</b> A plethora of tools are available to measure physical activity (PA), sedentary behaviour (SB) and sleep quality (SQ). Ideally, the measurement evaluation these outcomes would be combined reflect their synergistic relationships across 24-hour day. Current guidance focusses only on PA (Burtin et al. Chest 2021). <b>Aim:</b> To synthesise approaches used in PR trials examining changes PA, SB SQ. <b>Methods:</b> Systematic review randomised PR, reporting or SQ outcomes....

10.1183/13993003.congress-2023.pa2692 article EN 01.02 - Rehabilitation and chronic care 2023-09-09

<b>Introduction:</b> There is high COPD mortality in economically deprived areas of Rajasthan and no existing PR programmes. <b>Aim:</b> To determine the feasibility screening recruiting people with to a community-based program an area Jodhpur, Rajasthan. <b>Methods:</b> Door-to-door surveys were conducted find suspected chronic respiratory diseases, followed by spirometry-based diagnosis COPD. Barriers challenges documented based on responses patients, their family members, community...

10.1183/13993003.congress-2023.pa4991 article EN 01.02 - Rehabilitation and chronic care 2023-09-09

<b>Background:</b> IPF burden in India is high. PR an effective intervention but access limited globally and India. HBPR models may offer a suitable option as services develop. <b>Aim:</b> To explore the experiences of people with participating programme. <b>Method:</b> Individuals who have participated were invited to complete either face-to-face or telephone semi-structured interview. The programme was supported using specifically designed paper-based manual for based upon SPACEforCOPD©...

10.1183/13993003.congress-2023.pa4983 article EN 01.02 - Rehabilitation and chronic care 2023-09-09

<b>Introduction:</b> The VitaBreath (Philips) is a portable, handheld, non-invasive ventilation device (pNIV) intended to relieve activity-related shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP: 18; EPAP: 8 cmH2O). However, IPAP EPAP may cause circulatory compromise. We investigated the effects pNIV during normal breathing (NB) after Eucapnic Voluntary Hyperventilation trial (EVH) sustained at 80% MVV. <b>Methods:</b> In balanced...

10.1183/13993003.congress-2019.pa757 article EN 01.05 - Clinical respiratory physiology, exercise and functional imaging 2019-09-28

<b>Background:</b> Intermittent use of pNIV (providing fixed IPAP (18 cmH<sub>2</sub>O) and EPAP (8 cmH<sub>2</sub>O)) facilitates more rapid recovery from exercise-induced dynamic hyperinflation (DH) breathlessness compared to pursed lip breathing (PLB) in COPD. <b>Methods:</b> In 11 patients with COPD (FEV<sub>1</sub>: 63±3% predicted) we assessed thoracoabdominal volumes using optoelectronic plethysmography Borg following 1-min application (VitaBreath, Philips Respironics) or PLB...

10.1183/13993003.congress-2020.2129 article EN 01.05 - Clinical respiratory physiology, exercise and functional imaging 2020-09-07

<h3>Objectives</h3> We investigated the effect of inspiratory muscle training (IMT) on strength, functional capacity and respiratory kinematics during exercise in older adults. <h3>Methods</h3> 24 adults (age: 68.3±2.5 years) were evenly randomised into an experimental or control (SHAM-IMT) group. Both groups performed 30 breaths, twice daily, for 8 weeks, with IMT group at intensity ~50% maximal pressure (PImax) SHAM-IMT &lt;15% PImax. Measurements PImax, breathing discomfort (Borg scale...

10.1136/thorax-2022-btsabstracts.16 article EN 2022-11-01

<b>Background:</b> Reduced inspiratory muscle strength is characteristic of the healthy ageing process. <b>Methods:</b> 24 adults (mean age: 68.3±2.5 years) were evenly randomised into an training (IMT) or sham group. Participants in IMT group performed 30 breaths, twice daily, for 8 weeks, at initial intensity corresponding to ~50% maximal pressure (PImax) and &lt;15% PImax Pre- 8-week measurements included PImax, six-minute walk distance (6MWD), assessment thoracoabdominal volumes via...

10.1183/13993003.congress-2022.2378 article EN 01.05 - Clinical respiratory physiology, exercise and functional imaging 2022-09-04

<h3>Background</h3> We previously identified that 8/24 COPD patients did not improve dynamic hyperinflation (DH) (DH non-responders) with the application of portable non-invasive ventilation (pNIV; Inspiratory/Expiratory Positive Airway Pressure: 18/8 cmH<sub>2</sub>O) compared to pursed lip breathing (PLB) technique during recovery from intermittent exercise (Chynkiamis <i>et al</i> 2020). In present study we employed Optoelectronic Plethysmography acute pNIV and PLB in examine potential...

10.1136/thorax-2020-btsabstracts.19 article EN 2021-01-21
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