A5101637234- Gut microbiota and health
- Diet and metabolism studies
- Genetics and Plant Breeding
- Crop Yield and Soil Fertility
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- Forest ecology and management
- Agricultural Science and Fertilization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Rice Cultivation and Yield Improvement
- Liver Disease Diagnosis and Treatment
- Plant Water Relations and Carbon Dynamics
- Antibiotic Resistance in Bacteria
- Gastrointestinal motility and disorders
- Digestive system and related health
- Probiotics and Fermented Foods
- Genetic and Environmental Crop Studies
- Ecology and Vegetation Dynamics Studies
- Iron Metabolism and Disorders
- Agricultural pest management studies
Pennsylvania State University
2015-2025
National Institute for Implementation Research on Non-Communicable Diseases
2023-2025
Suamandeep Vidyapeeth University
2023-2024
Indian Institute of Technology Jammu
2023-2024
ICAR-Indian Institute of Maize Research
2024
Lovely Professional University
2024
Utah State University
2022
Narendra Dev University of Agriculture and Technology
2018-2021
Central Drug Research Institute
2017-2021
Translational Health Science and Technology Institute
2021
Diets rich in fermentable fibres provide an array of health benefits; however, many patients with IBD report poor tolerance to fibre-rich foods. Intervention studies dietary murine models colonic inflammation have yielded conflicting results on whether ameliorate or exacerbate IBD. Herein, we examined how replacing the insoluble fibre, cellulose, fibres, inulin pectin, impacted colitis resulting from immune dysregulation via inhibition interleukin (IL)-10 signalling and/or innate deficiency...
Abstract Bacteria in the gastrointestinal tract produce amino acid bile amidates that can affect host-mediated metabolic processes 1–6 ; however, bacterial gene(s) responsible for their production remain unknown. Herein, we report salt hydrolase (BSH) possesses dual functions metabolism. Specifically, identified a previously unknown role BSH as an amine N -acyltransferase conjugates amines to acids, thus forming (BBAAs). To characterize this activity, used pharmacological inhibition of BSH,...
Agronomy is the science and technology of crop soil management for producing food, fiber, feed, fuel. As global population continues to rise, agronomy will play an increasingly vital role in meeting escalating food demands while sustaining natural resources. This review highlights major advancements agronomic research practice that enhance yields, health, agricultural sustainability worldwide. Key topics include plant breeding improved varieties, optimized nutrition fertility management,...
During an inflammatory response in the gut, some commensal bacteria such as E. coli can thrive and contribute to disease. Here we demonstrate that enterobactin (Ent), a catecholate siderophore released by coli, is potent inhibitor of myeloperoxidase (MPO), bactericidal enzyme host. Glycosylated Ent (salmochelin) non-catecholate siderophores (yersiniabactin ferrichrome) fail inhibit MPO activity. An mutant (ΔfepA) overproduces Ent, but not Ent-deficient double (ΔaroB/ΔfepA), inhibits activity...
Lipocalin 2 (Lcn2) is a multifunctional innate immune protein whose expression closely correlates with extent of intestinal inflammation. However, whether Lcn2 plays role in the pathogenesis gut inflammation unknown. Herein, we investigated to which regulates and bacterial dysbiosis mouse models IBD.Lcn2 was monitored murine colitis upon microbiota ablation/restoration. WT knockout (Lcn2KO) mice were analyzed for load, composition by 16S rRNA gene pyrosequencing and, their colitogenic...
With an increasing interest in dietary fibers (DFs) to promote intestinal health and the growth of beneficial gut bacteria, there is a continued rise incorporation refined DFs processed foods. It still unclear how fibers, such as guar gum, affect microbiota activity pathogenesis inflammatory bowel disease (IBD). Our study elucidated effect underlying mechanisms fermentable DF (FDF) commonly present wide range foods, on colitis development. We report that gum containing diet (GuD) increased...
Understanding niche and its parameters including breadth overlap hold promise in discerning the needs, tolerances of organisms also extent among sympatric species. Such information is critical to conservation management important forest tree In view lack any detailed previous study on this aspect Western Himalayan temperate forests Indian Region, present was carried out characterize respect their breadth, interspecific association between various dominant species 13 subtypes Moist Temperate...
Neutrophils are the primary immune cells that respond to inflammation and combat microbial transgression. To thrive, bacteria residing in their mammalian host have withstand antibactericidal responses of neutrophils. We report enterobactin (Ent), a catecholate siderophore expressed by Escherichia coli, inhibited PMA-induced generation reactive oxygen species (ROS) neutrophil extracellular traps (NETs) mouse human Ent also impaired degranulation granules phagocytosis bactericidal activity...
Owing to their health benefits, dietary fermentable fibers, such as refined inulin, are increasingly fortified in processed foods enhance nutritional value. However, we previously demonstrated that when inulin was fed Toll-like receptor 5 deficient (T5KO) mice susceptible dysbiosis, a subset of them developed cholestasis and subsequently liver cancer gut microbiota-dependent manner. Therefore, hypothesized clearance bacterial taxa, thereby metabolites, involved the onset progression could...
There is an increased risk of colon cancer associated with inflammatory bowel disease (IBD). Dietary fibers (DFs) naturally present in vegetables and whole grains offer numerous beneficial effects on intestinal health. However, the refined DFs health remain unclear. Therefore, we elucidated impact DF inulin colonic inflammation tumorigenesis.Four-week-old wild-type (WT) mice were fed diets containing insoluble cellulose (control) or for 4 weeks. A subgroup was then switched to drinking water...
Atherosclerosis and resulting cardiovascular disease are the leading causes of death in US. Hyperhomocysteinemia (HHcy), or accumulation intermediate amino acid homocysteine, is an independent risk factor for atherosclerosis, but intricate biological processes mediating this effect remain elusive. Several factors regulate homocysteine levels, including activity several enzymes adequate levels their coenzymes, pyridoxal phosphate (vitamin B6), folate B9), methylcobalamin B12). To better...
The experiment was conducted with twenty-two (22) genotypes of fieldpea including four (4) checks in Randomized Block Design three replications at the experimental farm department Genetics and Plant Breeding, Faculty Agriculture, Kamla Nehru Institute Physical Social Sciences Sultanpur 228118 (U.P.) India, during Rabi, season 2022-2023. Phenotypic data were recorded for nine characters viz. Days to 50% flowering, height, Branches per plant, Number pods maturity, Harvest index, 100-seed...