A5004910754- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Breastfeeding Practices and Influences
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Peroxisome Proliferator-Activated Receptors
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Nutrition, Genetics, and Disease
- Child Nutrition and Water Access
- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
- Obesity, Physical Activity, Diet
- Occupational Health and Performance
- Birth, Development, and Health
- Digestive system and related health
- Gestational Diabetes Research and Management
- Hemoglobinopathies and Related Disorders
- Gut microbiota and health
- Cancer Risks and Factors
- Lipid metabolism and biosynthesis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Pennsylvania State University
2016-2025
Walker (United States)
2016-2017
Laban/Bartenieff Institute of Movement Studies
2014
Old Dominion University
2011
Diets rich in fermentable fibres provide an array of health benefits; however, many patients with IBD report poor tolerance to fibre-rich foods. Intervention studies dietary murine models colonic inflammation have yielded conflicting results on whether ameliorate or exacerbate IBD. Herein, we examined how replacing the insoluble fibre, cellulose, fibres, inulin pectin, impacted colitis resulting from immune dysregulation via inhibition interleukin (IL)-10 signalling and/or innate deficiency...
Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled for endogenous medium-/long-chain acids that attenuates metabolic disease and inflammation. However, the function of Ffar4 in heart unclear. Given its putative beneficial role, we hypothesized would protect from pathologic stress.
Obesity is associated with chronic inflammation and a risk factor for insufficient milk production. Inflammation-mediated suppression of LPL could inhibit mammary uptake long-chain fatty acids (LCFAs; >16 carbons). In an ancillary case–control analysis, we investigated whether women low production despite regular breast emptying have elevated disrupted transfer LCFAs from plasma into milk. Data specimens supply study exclusively breastfeeding control group were analyzed, measured by 24-h...
Aberrant high-density lipoprotein (HDL) function is implicated in inflammation-associated pathologies. While HDL ABCA1-mediated reverse cholesterol and phospholipid transport are well described, the movement of pro-/anti-inflammatory lipids has not been explored. phospholipids largest reservoir circulating arachidonic acid-derived oxylipins. Endotoxin-stimulation activates inflammatory cells leading to hydroxyeicosatetraenoic acid (HETE) production, oxylipins which involved response...
Military personnel engage in strenuous physical activity and load carriage. This study evaluated the role of body mass added on aerobic performance (uphill treadmill exercise) pulmonary function. Performance a traditional unloaded run test (4.8 km) was compared with loaded tasks. Subjects performed an outdoor 4.8-km 4 maximal tests wearing loads 0, 10, 20, 30 kg. Subjects' function (forced expired volume 1 second [FEV1], forced vital capacity [FVC], voluntary ventilation [MVV]) tested each...
Oxylipins are produced enzymatically from polyunsaturated fatty acids, abundant in triglyceride-rich lipoproteins (TGRLs), and mediate inflammatory processes. Inflammation elevates TGRL concentrations, but it is unknown if the acid oxylipin compositions change. In this study, we investigated effect of prescription ω-3 ethyl esters (P-OM3; 3.4 g/d EPA + DHA) on lipid response to an endotoxin challenge (lipopolysaccharide; 0.6 ng/kg body weight). Healthy young men (N = 17) were assigned 8-12...
In adipose, insulin functions to suppress intracellular lipolysis and secretion of nonesterified fatty acid (NEFA) into plasma. We applied glucose NEFA minimal models (MM) following a frequently sampled intravenous tolerance test (FSIVGTT) assess glucose-specific NEFA-specific resistance. used total individual acids in the MM, comparing model parameters metabolic syndrome (MetSyn) subjects (n = 52) with optimally healthy controls (OptHC; n 14). Results are reported as mean difference (95%...
Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation inflammation, vascular tone, hemostasis, and thrombosis. Very low-density lipoproteins (VLDL) contain oxylipins, but it is unknown whether the liver regulates their concentrations. In this study, we used a perfused model to observe effect inflammatory lipopolysaccharide (LPS) challenge soluble epoxide hydrolase inhibition (sEHi) on VLDL oxylipins. A compartmental deuterium-labeled...
Abstract Iron deficiency in pregnancy is related to many poor health outcomes, including anemia and low birth weight. A small number of previous studies have identified maternal body mass index (BMI) as potential risk factors for iron status. Our objective was examine the association between pre-pregnancy BMI status a nationally representative sample US adult women. We used data from National Health Nutrition Examination Survey (NHANES; 1999-2010) pregnant women ages 18-49 years (n=1156)....
Abstract Supranutritional use of vitamins may have an impact on mortality rates sows and piglets. Specifically, injection vitamin A, A D (VitAD) has improved subsequent preweaning when given to after weaning immune response in offspring administered cattle late gestation. However, little work been conducted investigate developmental impacts gestational supplementation piglets that development. To the relationship VitAD development, this study evaluated (n = 20) injected intramuscularly with...
Objectives: Vitamin D deficiency is a global health issue and may impact milk supply through modulating mammary inflammation lipid metabolism. However, data limited on the role of vitamin in lactation outcomes. We aimed to examine supplementation exclusive breastfeeding prevalence during early infancy. Methods: This secondary analysis randomized controlled trial maternal Dhaka, Bangladesh. In this study, participants received either prenatal (4200 IU/wk, n=229; 16000 n=224; or 28000 n=221),...